Ha-ras and v-raf oncogenes, but not int-2 and c-myc, interfere with the lactogenic hormone dependent activation of the mammary gland specific transcription factor.

Raf-1 activates MAP kinase-kinase

1992 • 1,308 citations

Prolactin regulation of beta-casein gene expression and of a cytosolic 120-kd protein in a cloned mouse mammary epithelial cell line.

1988 • 513 citations

Raf-1 protein kinase is required for growth of induced NIH/3T3 cells

1991 • 489 citations

Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus.

1983 • 485 citations

Transformation by activated ras or fos prevents myogenesis by inhibiting expression of MyoD1

1989 • 286 citations

Beta-casein gene promoter activity is regulated by the hormone-mediated relief of transcriptional repression and a mammary-gland-specific nuclear factor.

1991 • 284 citations

Accumulation of p21ras.GTP in response to stimulation with epidermal growth factor and oncogene products with tyrosine kinase activity.

1990 • 264 citations

Glucocorticoid responsiveness of the transcriptional enhancer of Moloney Murine Sarcoma Virus

1986 • 262 citations

Prolactin and glucocorticoid hormones synergistically induce expression of transfected rat beta-casein gene promoter constructs in a mammary epithelial cell line.

1989 • 257 citations

Role of Raf-1 serine/threonine protein kinase in growth factor signal transduction.

1991 • 248 citations

Raf-1: A kinase currently without a cause but not lacking in effects

1991 • 155 citations

ras-induced neuronal differentiation of PC12 cells: possible involvement of fos and jun.

1989 • 140 citations

Mammary gland-specific nuclear factor is present in lactating rodent and bovine mammary tissue and composed of a single polypeptide of 89 kDa.

1992 • 137 citations

Epidermal Growth Factor Receptor, but Not c-erbB-2, Activation Prevents Lactogenic Hormone Induction of the β-Casein Gene in Mouse Mammary Epithelial Cells

1990 • 129 citations

Growth control and differentiation in mammary epithelial cells.

1989 • 125 citations

Developmental and environmental regulation of a mammary gland-specific nuclear factor essential for transcription of the gene encoding beta-casein.

1992 • 116 citations

Epidermal growth factor (EGF) stimulates association and kinase activity of Raf-1 with the EGF receptor.

1991 • 115 citations

Epidermal growth factor receptor, platelet-derived growth factor receptor, and c-erbB-2 receptor activation all promote growth but have distinctive effects upon mouse mammary epithelial cell differentiation.

1991 • 115 citations

Ras controls coupling of growth factor receptors and protein kinase C in the membrane to Raf-1 and B-Raf protein serine kinases in the cytosol.

1992 • 111 citations

The regulation and function of p21ras in T cells

1992 • 98 citations

Mammary gland-specific nuclear factor activity is positively regulated by lactogenic hormones and negatively by milk stasis.

1992 • 72 citations

Oncogenes at viral integration sites.

1990 • 67 citations

Induction of the endogenous whey acidic protein (Wap) gene and a Wap-myc hybrid gene in primary murine mammary organoids

1990 • 40 citations

V-MycAlters the Response of a Cloned Mouse Mammary Epithelial Cell Line to Lactogenic Hormones

1988 • 32 citations

Epidermal growth factor stimulates phosphorylation of RAF-1 independently of receptor autophosphorylation and internalization

1991 • 30 citations

H-ras induced transformation of mammary epithelium is favoured by increased oncogene expression or by inhibition of mammary regression.

1991 • 24 citations

The mouse int-2 gene exhibits basic fibroblast growth factor activity in a basic fibroblast growth factor-responsive cell line.

1990 • 21 citations

Transformation of MMC‐E epithelial cells by acute 3611‐MSV: inhibition of collagen synthesis and induction of novel polypeptides

1982 • 16 citations

The int-2 gene product acts as a growth factor and substitutes for basic fibroblast growth factor in promoting the differentiation of a normal mouse mammary epithelial cell line.

1992 • 12 citations

Oncogene expression in mammary epithelial cells

1992 • 11 citations

Epidermal Growth Factor, Glucocorticoid Hormones and Prolactin Act Sequentially in the Induction of Milk Protein Gene Expression

1992 • 4 citations