Epidermal growth factor (EGF) stimulates association and kinase activity of Raf-1 with the EGF receptor.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Transforming gene product of Rous sarcoma virus phosphorylates tyrosine

1980 • 2,387 citations

Coated pits, coated vesicles, and receptor-mediated endocytosis

1979 • 2,073 citations

Receptor-Mediated Endocytosis: Concepts Emerging from the LDL Receptor System

1985 • 1,585 citations

[42] Detection and quantification of phosphotyrosine in proteins

1983 • 1,184 citations

Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

1989 • 978 citations

EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling

1989 • 784 citations

Requirement for c-ras proteins during viral oncogene transformation

1986 • 680 citations

Direct activation of the serine/threonine kinase activity of raf-1 through tyrosine phosphorylation by the PDGF β-receptor

1989 • 513 citations

Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing

1987 • 479 citations

Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity.

1988 • 458 citations

Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body

1990 • 452 citations

Evidence that pp42, a major tyrosine kinase target protein, is a mitogen-activated serine/threonine protein kinase.

1989 • 442 citations

Epidermal growth factor stimulates tyrosine phosphorylation of phospholipase C-II independently of receptor internalization and extracellular calcium.

1989 • 402 citations

Characterization of insulin-stimulated microtubule-associated protein kinase. Rapid isolation and stabilization of a novel serine/threonine kinase from 3T3-L1 cells.

1988 • 257 citations

Mutational Activation of c-raf-1 and Definition of the Minimal Transforming Sequence

1990 • 232 citations

The complete coding sequence of the human raf oncogene and the corresponding structure of the c-raf-1 gene

1986 • 225 citations

Identification and characterization of a mitogen-activated S6 kinase.

1988 • 223 citations

Reconstitution of human epidermal growth factor receptors and its deletion mutants in cultured hamster cells.

1986 • 222 citations

Purification and characterization of a protein kinase from Xenopus eggs highly specific for ribosomal protein S6.

1986 • 207 citations

Expression of raf family proto-oncogenes in normal mouse tissues.

1990 • 194 citations

Tyrosine kinase activity is essential for the association of phospholipase C-gamma with the epidermal growth factor receptor.

1990 • 188 citations

A mutant epidermal growth factor receptor with defective protein tyrosine kinase is unable to stimulate proto-oncogene expression and DNA synthesis.

1987 • 186 citations

Interleukin-3 and granulocyte-macrophage colony-stimulating factor mediate rapid phosphorylation and activation of cytosolic c-raf.

1990 • 179 citations

Activation of S6 kinase activity in 3T3-L1 cells by insulin and phorbol ester.

1985 • 155 citations

B-raf, a new member of the raf family, is activated by DNA rearrangement.

1988 • 149 citations

Insulin activates the kinase activity of the Raf-1 proto-oncogene by increasing its serine phosphorylation.

1990 • 148 citations

T cell antigen receptor engagement stimulates c-raf phosphorylation and induces c-raf-associated kinase activity via a protein kinase C-dependent pathway.

1990 • 147 citations

Mutational activation of c-raf-1 and definition of the minimal transforming sequence.

1990 • 146 citations

The complete coding sequence of the human A-raf-1 oncogene and transforming activity of a human A-rafcarrying retrovirus

1987 • 145 citations

Transactivation of c-fos and β-actin genes by raf as a step in early response to transmembrane signals

1990 • 138 citations

Colony stimulating factor-1 (CSF-1) stimulates temperature dependent phosphorylation and activation of the RAF-1 proto-oncogene product.

1990 • 128 citations

raf Family Serine/Threonine Protein Kinases in Mitogen Signal Transduction

1988 • 124 citations

Expression of raf oncogenes activates the PEA1 transcription factor motif.

1989 • 101 citations

Insulin activates the Raf-1 protein kinase.

1990 • 99 citations

An insertional mutant of epidermal growth factor receptor allows dissection of diverse receptor functions.

1987 • 85 citations

Receptor-Mediated Endocytosis: Concepts Emerging from the LDL Receptor System

1985 • 78 citations

Purification and Characterization of a 40 S Ribosomal Protein S6 Kinase from Vanadate-stimulated Swiss 3T3 Cells

1989 • 76 citations

Genes and Signal Transduction in Multistage Carcinogenesis

1990 • 73 citations

Activation of the Serum Response Element and 12-O-Tetradecanoylphorbol-13-Acetate Response Element by the Activated c-raf-1 Protein in a Manner Independent of Protein Kinase C

1989 • 71 citations

Stimulation of ribosomal protein S6 kinase activity by pp60v-src or by serum: dissociation from phorbol ester-stimulated activity.

1986 • 68 citations

Induction of transformation and DNA synthesis after microinjection of raf proteins.

1990 • 37 citations

Expression of raf family proto-oncogenes in normal mouse tissues.

1990 • 37 citations

Transformation by raf and myc oncogenes.

1986 • 26 citations

Preparation of raf-oncogene-specific antiserum with raf protein produced in E. coli

1988 • 21 citations

A Mutant Epidermal Growth Factor Receptor with Defective Protein Tyrosine Kinase Is Unable To Stimulate Proto-Oncogene Expression and DNA Synthesis

1987 • 17 citations

Induction of Transformation and DNA Synthesis after Microinjection of raf Proteins

1990 • 12 citations

Role of raf and myc Oncogenes in Signal Transduction

2020 • 4 citations