The int-2 gene product acts as a growth factor and substitutes for basic fibroblast growth factor in promoting the differentiation of a normal mouse mammary epithelial cell line.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

THE HEPARIN-BINDING (FIBROBLAST) GROWTH FACTOR FAMILY OF PROTEINS

1989 • 1,948 citations

Proteoglycans as modulators of growth factor activities

1991 • 1,338 citations

Structural Characterization and Biological Functions of Fibroblast Growth Factor

1987 • 1,299 citations

Redesign of Retrovirus Packaging Cell Lines To Avoid Recombination Leading to Helper Virus Production

1986 • 1,276 citations

Increased cell division as a cause of human cancer.

1990 • 894 citations

Cooperation between oncogenes

1991 • 792 citations

Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors.

1990 • 635 citations

Inactivation of the Retinoblastoma Susceptibility Gene in Human Breast Cancers

1988 • 608 citations

Basic fibroblast growth factor binds to subendothelial extracellular matrix and is released by heparitinase and heparin-like molecules

1989 • 597 citations

Human basic fibroblast growth factor gene encodes four polypeptides: three initiate translation from non-AUG codons.

1989 • 527 citations

Prolactin regulation of beta-casein gene expression and of a cytosolic 120-kd protein in a cloned mouse mammary epithelial cell line.

1988 • 513 citations

Expression of the FGF-related proto-oncogene int-2 during gastrulation and neurulation in the mouse.

1988 • 384 citations

Tumorigenesis by mouse mammary tumor virus: Proviral activation of a cellular gene in the common integration region int-2

1984 • 356 citations

Translocation of bFGF to the nucleus is G1 phase cell cycle specific in bovine aortic endothelial cells.

1990 • 324 citations

Expression pattern of the FGF-related proto-oncogene int-2 suggests multiple roles in fetal development

1989 • 309 citations

Subcellular fate of the lnt-2 oncoprotein is determined by choice of initiation codon

1990 • 293 citations

The int-2 gene product acts as an epithelial growth factor in transgenic mice.

1990 • 263 citations

K-sam, an amplified gene in stomach cancer, is a member of the heparin-binding growth factor receptor genes.

1990 • 260 citations

Prolactin and glucocorticoid hormones synergistically induce expression of transfected rat beta-casein gene promoter constructs in a mammary epithelial cell line.

1989 • 257 citations

Sequence, topography and protein coding potential of mouse int-2: a putative oncogene activated by mouse mammary tumour virus.

1986 • 234 citations

Two proto-oncogenes implicated in mammary carcinogenesis, int-1 and int-2, are independently regulated during mouse development.

1986 • 211 citations

Evidence that p53 behaves as a tumour suppressor gene in sporadic breast tumours.

1990 • 165 citations

Mutations in Human Breast Cancer: An Overview

1989 • 155 citations

Cell-cell interactions promote mammary epithelial cell differentiation.

1985 • 143 citations

Multiple RNAs expressed from the int-2 gene in mouse embryonal carcinoma cell lines encode a protein with homology to fibroblast growth factors.

1988 • 130 citations

Epidermal Growth Factor Receptor, but Not c-erbB-2, Activation Prevents Lactogenic Hormone Induction of the β-Casein Gene in Mouse Mammary Epithelial Cells

1990 • 129 citations

The int genes in mammary tumorigenesis and in normal development

1988 • 117 citations

Epidermal growth factor receptor, platelet-derived growth factor receptor, and c-erbB-2 receptor activation all promote growth but have distinctive effects upon mouse mammary epithelial cell differentiation.

1991 • 115 citations

Immunological detection and quantitation of alpha transforming growth factors in human breast carcinoma cells

1986 • 114 citations

Transforming growth factor-alpha expression is enhanced in human mammary epithelial cells transformed by an activated c-Ha-ras protooncogene but not by the c-neu protooncogene, and overexpression of the transforming growth factor-alpha complementary DNA leads to transformation.

1990 • 109 citations

The murine flg gene encodes a receptor for fibroblast growth factor.

1990 • 106 citations

Transformation of human mammary epithelial cells by oncogenic retroviruses.

1988 • 103 citations

The use of polyvinylidenedifluoride membranes as a general blotting matrix

1988 • 95 citations

The significance of oncogene amplification in primary breast cancer

1989 • 94 citations

Four classes of mRNA are expressed from the mouse int-2 gene, a member of the FGF gene family.

1988 • 67 citations

Detection and Characterization of the Fibroblast Growth Factor-Related Oncoprotein INT-2

1989 • 66 citations

Different growth factors stimulate cell division of rat mammary epithelial, myoepithelial, and stromal cell lines in culture

1984 • 61 citations

Autocrine growth stimulation by secreted Kaposi fibroblast growth factor but not by endogenous basic fibroblast growth factor.

1990 • 56 citations

Growth stimulation of human breast epithelial cells by basic fibroblast growth factor in serum‐free medium

1989 • 55 citations

Appearance of basic fibroblast growth factor receptors upon differentiation of rat mammary epithelial to myoepithelial‐like cells in culture

1990 • 47 citations

Cell transformation by Int-2--a member of the fibroblast growth factor family.

1991 • 46 citations

Basic fibroblast growth factor stimulates the growth and inhibits casein accumulation in mouse mammary epithelial cells in vitro

1989 • 30 citations

Growth and continuous passage of COMMA-D mouse mammary epithelial cells in hormonally defined serum-free medium.

1987 • 26 citations

The mouse int-2 gene exhibits basic fibroblast growth factor activity in a basic fibroblast growth factor-responsive cell line.

1990 • 21 citations