Growth control and differentiation in mammary epithelial cells.

Multiple hormone interactions in the developmental biology of the mammary gland.

1980 • 866 citations

The Function and Mechanism of Promoters of Carcinogenesis

1973 • 759 citations

Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin.

1987 • 648 citations

Maintenance and induction of morphological differentiation in dissociated mammary epithelium on floating collagen membranes

1977 • 641 citations

Mammary ductal elongation: Differentiation of myoepithelium and basal lamina during branching morphogenesis

1983 • 453 citations

Serum-free growth of human mammary epithelial cells: rapid clonal growth in defined medium and extended serial passage with pituitary extract.

1984 • 435 citations

Reversible Inhibition of Mammary Gland Growth by Transforming Growth Factor-β

1987 • 408 citations

Epidermal Growth Factor: Effects of Androgens and Adrenergic Agents

1974 • 393 citations

Epidermal growth factor: morphological demonstration of binding, internalization, and lysosomal association in human fibroblasts.

1978 • 358 citations

Growth of normal human mammary cells in culture

1980 • 316 citations

Induction of Epidermal Growth Factor-Related Polypeptides by 17β-Estradiol in MCF-7 Human Breast Cancer Cells

1986 • 296 citations

Sustained growth and three-dimensional organization of primary mammary tumor epithelial cells embedded in collagen gels.

1979 • 285 citations

Endocrine Control of Mammary-Gland Development and Function in the C3H/He Crgl Mouse<xref ref-type="fn" rid="FN1">2</xref>

1958 • 281 citations

The hormonal control of mammary growth and lactation.

1958 • 267 citations

Extracellular matrix promotes mammary epithelial growth and differentiation in vitro.

1982 • 262 citations

Hormone-dependent differentiation of mammary gland in vitro.

1965 • 222 citations

Presence of transforming growth factors in human breast cancer cells.

1984 • 222 citations

Prolactin–progesterone antagonism in self regulation of prolactin receptors in the mammary gland

1977 • 180 citations

Comparison of the whey acidic protein genra of the rat and mouse

1984 • 176 citations

The role of DNA synthesis and mitosis in hormone-dependent differentiation.

1966 • 175 citations

Differential response to growth factor by rat mammary epithelium plated on different collagen substrata in serum-free medium.

1981 • 167 citations

Epidermal growth factor requirement for development of cultured mammary gland

1980 • 165 citations

Enzymic assay for galactosyl transferase activity of lactose synthetase and α-lactalbumin in purified and crude systems

1970 • 164 citations

The physiology of lactation

1971 • 161 citations

The Gestational Pattern of Estradiol, Testosterone and Progesterone Secretion in Selected Strains of Mice

1979 • 155 citations

Lactogenic Hormones: Binding Sites, Mammary Growth, Secretory Cell Differentiation, and Milk Biosynthesis in Ruminants

1985 • 150 citations

Growth Factor- and Cyclic Nucleotide-Induced Proliferation of Normal and Malignant Mammary Epithelial Cells in Primary Culture*

1980 • 145 citations

Cell-cell interactions promote mammary epithelial cell differentiation.

1985 • 143 citations

SOME ULTRASTRUCTURAL EFFECTS OF INSULIN, HYDROCORTISONE, AND PROLACTIN ON MAMMARY GLAND EXPLANTS

1970 • 140 citations

Characterization and Cloning of the mRNAs Specific for the Lactating Mouse Mammary Gland

1982 • 134 citations

Responses of Mammary Cells to Hormones

1976 • 133 citations

The role of epithelial growth factor in mammary gland development in vitro

1969 • 128 citations

Epidermal Growth Factor Stimulates Cell Proliferation and Inhibits Functional Differentiation of Mouse Mammary Epithelial Cells in Culture*

1983 • 126 citations

The differential actions of cortisol on the accumulation of α-lactalbumin and casein in midpregnant mouse mammary gland in culture

1980 • 124 citations

INFLUENCE OF HORMONES ON LOBULO-ALVEOLAR DIFFERENTIATION OF MOUSE MAMMARY GLANDS IN VITRO

1966 • 123 citations

Evidence for the involvement of the submandibular gland epidermal growth factor in mouse mammary tumorigenesis.

1985 • 118 citations

Serum-free growth of normal and tumor mouse mammary epithelial cells in primary culture.

1982 • 118 citations

Calcium regulation of normal human mammary epithelial cell growth in culture

1984 • 113 citations

Augmentation of the response of normal mammary epithelial cells to estradiol by mammary stroma.

1983 • 110 citations

Induction of androgen receptor formation by epithelium-mesenchyme interaction in embryonic mouse mammary gland.

1982 • 110 citations

Evolution of the casein multigene family: conserved sequences in the 5′ flanking and exon regions

1986 • 110 citations

Development and loss of androgen responsiveness in the embryonic rudiment of the mouse mammary gland

1977 • 107 citations

Spectrophotometry in the Far Ultraviolet

1957 • 107 citations

Relative Distribution of Estrogen and Progesterone Receptors among the Epithelial, Adipose, and Connective Tissue Components of the Normal Mammary Gland*

1981 • 102 citations

Organization and sequence of the human α-lactalbumin gene

1987 • 99 citations

Effect of ovarian hormones on duration of DNA synthesis in cells of the C3H mouse mammary gland

1965 • 99 citations

Hormone-dependent Accumulation of Rough Endoplasmic Reticulum in Mouse Mammary Epithelial Cells in Vitro

1971 • 98 citations

Comparative sequence analysis of the mRNAs coding for mouse and rat whey protein

1982 • 91 citations

Rapid down-regulation of prolactin receptors in mammary gland and liver

1979 • 86 citations

Epidermal Growth Factor Receptor Levels in Mouse Mammary Glands in Various Physiological States*

1985 • 86 citations

Evidence for physiological function of epidermal growth factor: pregestational sialoadenectomy of mice decreases milk production and increases offspring mortality during lactation period.

1984 • 86 citations

Cell proliferation in the human mammary epithelium. Differential contribution by epithelial and myoepithelial cells.

1986 • 86 citations

Changes in epidermal growth factor concentrations of submandibular gland, plasma and urine of normal and sialoadenectomized female mice during various reproductive stages

1985 • 86 citations

Prolactin Regulation of Cytological Differentiation of Mammary Epithelial Cells in Periparturient Cows*

1981 • 83 citations

The Effect of Progestins on Submaxillary Gland Epidermal Growth Factor: Demonstration of Androgenic, Synandrogenic and Antiandrogenic Actions

1975 • 81 citations

3T3-L1 Adipocytes promote the growth of mammary epithelium

1984 • 81 citations

Multihormonal Regulation of Casein Gene Expression at the Transcriptional and Posttranscriptional Levels in the Mammary Gland

1980 • 78 citations

Biological action of epidermal growth factor and its functional receptors in normal mammary epithelial cells.

1983 • 74 citations

Prolactin and Estrogen Binding Sites in the Mammary Gland of the Lactating and Non-Lactating Rat

1977 • 73 citations

Primary Culture of Human Mammary Epithelial Cells Embedded in Collagen Gels<xref ref-type="fn" rid="fn2">2</xref>

1980 • 73 citations

In vivo, cAMP stimulates growth and morphogenesis of mouse mammary ducts.

1984 • 70 citations

HORMONAL REGULATION OF LOBULO-ALVEOLAR GROWTH, FUNCTIONAL DIFFERENTIATION AND REGRESSION OF WHOLE MOUSE MAMMARY GLAND IN ORGAN CULTURE

1975 • 68 citations

Progesterone Receptors in Normal Mammary Glands of Mice: Characterization and Relationship to Development*

1979 • 67 citations

Ontogeny of Mesenchymal Androgen Receptors in the Embryonic Mouse Mammary Gland

1983 • 66 citations

Similar growth pattern of mouse mammary epithelium cultivated in collagen matrix in vivo and in vitro

1984 • 64 citations

Tumor promoter 12-O-tetradecanoylphorbol 13-acetate, like epidermal growth factor, stimulates cell proliferation and inhibits differentiation of mouse mammary epithelial cells in culture.

1983 • 63 citations

Morphogenesis and Growth Potentiality of Mammary Glands in Mice. I. Transplantability and Growth Potentiality of Mammary Tissue of Virgin Mice<xref ref-type="fn" rid="fn1">2</xref><xref ref-type="fn" rid="fn2">3</xref>

1962 • 62 citations

Development of Insulin-Sensitivity by Mouse Mammary Gland In Vitro

1970 • 61 citations

Essential Role of Insulin in Transcription of the Rat 25,000 Molecular Weight Casein Gene

1984 • 60 citations

Glucocorticoid Regulation of Prolactin Receptors on Mammary Cells in Culture*

1979 • 59 citations

Growth of human mammary epithelial cells on collagen gel surfaces.

1981 • 59 citations

Lobuloalveolar Differentiation in Mouse Mammary Tissues in vitro

1964 • 57 citations

A ROLE OF THE CELL CYCLE IN HORMONE-DEPENDENT DIFFERENTIATION

1974 • 57 citations

Differential response of normal rat mammary epithelial cells to mammogenic hormones and EGF

1985 • 56 citations

Fetal mammary gland differentiation in vitro in response to hormones

1970 • 55 citations

Transcriptional and post-transcriptional roles of glucocorticoid in the expression of the rat 25,000 molecular weight casein gene

1986 • 54 citations

Mammary Fat Pad May Be a Potential Site for Initiation of Estrogen Action in Normal Mouse Mammary Glands*

1984 • 53 citations

CHANGES IN INSULIN RESPONSIVENESS DURING DEVELOPMENT OF MAMMARY EPITHELIUM

1974 • 52 citations

Prolactin receptor on dissociated mammary epithelial cells at different stages of development

1978 • 51 citations

Cell size and shape changes in the myoepithelium of the mammary gland during differentiation

1986 • 50 citations

Construction and preliminary characterization of the rat casein and alpha-lactalbumin cDNA clones.

1981 • 49 citations

Correlation between Prolactin-Receptor Interaction, Down-Regulation of Receptors, and Stimulation of Casein and Deoxyribonucleic Acid Biosynthesis in Rabbit Mammary Gland Explants*

1982 • 49 citations

Fetal mammary gland differentiation in vitro in response to hormones

1970 • 48 citations

Nucleotide sequence of a cDNA encoding mouse beta casein

1986 • 48 citations

Hormonal Regulation of Breast Development and Activity

1974 • 48 citations

Vanadate enhances the stimulatory action of insulin on DNA synthesis in cultured mouse mammary gland

1980 • 47 citations

Induction by lithium ion of multiplication of mouse mammary epithelium in culture.

1979 • 46 citations

Purification and characterization of mouse α-lactalbumin and preparation of its antibody

1980 • 46 citations

Thyroid hormone regulation of prolactin binding to mouse mammary glands

1979 • 45 citations

Dispersed mammary epithelial cells. Receptors of lactogenic hormones in virgin, pregnant, and lactating rabbits.

1979 • 45 citations

Involvement of protein kinase C in mouse mammary gland development

1986 • 43 citations

Initiation of DNA synthesis in mammary epithelium and mammary tumors by lithium ions

1980 • 40 citations

Bifunctional Activity of Epidermal Growth Factor onα- andκ-Casein Gene Expression in Rodent Mammary Glandsin Vitro

1986 • 40 citations

Epidermal growth factor stimulates tyrosine phosphorylation of human glucocorticoid receptor in cultured cells

1987 • 40 citations

Nucleotide Sequence of Cloned cDNA Coding for Mouse ɛ Casein

1982 • 39 citations

METABOLIC ADAPTATIONS IN MOUSE MAMMARY GLAND DURING A NORMAL LACTATION CYCLE AND IN EXTENDED LACTATION

1987 • 39 citations

Regulation of Casein Synthesis by Polyamines in Mammary Gland Explants of Mice1

1977 • 38 citations

Sources of one-carbon units in the folate pathway of Escherichia coli.

1982 • 38 citations

Milk Protein Synthesis by Mammary Glands of Vitamin D-Deficient Mice

1987 • 36 citations

Changes in Scatchard Plots for Insulin Binding to Mammary Epithelial Cells from Cycling, Pregnant, and Lactating Mice*

1982 • 36 citations

The development in vitro of the mammary glands of the mouse.

1950 • 34 citations

Thyroid Hormone Regulation of Epidermal Growth Factor Receptor Levels in Mouse Mammary Glands

1986 • 32 citations

Induction of distinct types of spontaneous electrical activities in mammary epithelial cells by epidermal growth factor and insulin.

1986 • 32 citations

Hormone-Dependent Differentiation of Immature Mouse Mammary Gland in vitro

1967 • 31 citations

Possible roles of calcium and calmodulin in mammary gland differentiation in vitro

1985 • 30 citations

Stimulation of Mammary Epithelial Cell Proliferationin Vitroby Protein Factor (s) Present in Serum

1971 • 30 citations

Activation of casein synthesis by prostaglandins plus spermidine in mammary gland explants of mice

1976 • 29 citations

Cholera‐toxin‐enhanced growth of human breast cancer cell lines in vitro and in vivo: Interaction with estrogen

1985 • 29 citations

Prolactin effects on ion transport across cultured mouse mammary epithelium

1981 • 28 citations

Rat Mammary Gland Differentiation in vitro in the Absence of Steroids

1968 • 28 citations

Post-transcriptional stimulation of casein synthesis by thyroid hormone

1978 • 27 citations

1,25-Dihydroxycholecalciferol Receptor Regulation in Hormonally Induced Differentiation of Mouse Mammary Gland in Culture*

1987 • 27 citations

Different mitogenic and phenotypic responses of human breast epithelial cells grown in two versus three dimensions

1986 • 27 citations

Effect of thyroid status on development of spontaneous mammary tumors in primiparous C3H mice.

1982 • 27 citations

Stromal DNA synthesis is stimulated by young, but not serially aged, mouse mammary epithelium

1983 • 26 citations

Role of spermidine in casein gene expression in the rabbit

1978 • 26 citations

Cholera Toxin Treatment Increasesin VivoGrowth and Development of the Mouse Mammary Gland*

1985 • 26 citations

Retinoic Acid Enhances Cell Responses to Epidermal Growth Factor in Mouse Mammary Gland in Culture*

1986 • 26 citations

Involvement of collagen formation in the hormonally induced functional differentiation of mouse mammary gland in organ culture.

1983 • 26 citations

General Metabolism Associated with the Synthesis of Milk

1974 • 25 citations

Effect of bovine growth hormone on development of goat mammary tissue in organ culture.

1982 • 25 citations

The role of epidermal growth factor in normal and neoplastic growth of mouse mammary epithelial cells

1988 • 24 citations

Casein and α-lactalbumin messenger RNAs during the development of mouse mammary gland

1980 • 24 citations

EFFECT OF ESTROGENS, GONADOTROPINS AND GROWTH HORMONE ON MAMMARY GLANDS OF HYPOPHYSECTOMIZED RATS¹,²

1941 • 24 citations

Involvement of the Ca²⁺‐dependent K⁺ channel activity in the hyperpolarizing response induced by epidermal growth factor in mammary epithelial cells

1986 • 23 citations

Response of end bud cells from immature rat mammary gland to hormones when cultured in collagen gel

1983 • 23 citations

Reinitiation of Growth in Senescent Mouse Mammary Epithelium in Response to Cholera Toxin

1984 • 22 citations

Effect of estradiol on nonmalignant human mammary cells in primary culture.

1984 • 22 citations

Embryonic and Fetal Development of the Mammary Apparatus

1978 • 22 citations

The differential actions of cortisol on the synthesis and turnover of alpha-lactalbumin and casein and on accumulation of their mRNA in mouse mammary gland in organ culture

1983 • 22 citations

Functional differentiation of virgin mouse mammary epithelium in explant culture is dependent upon extracellular proline

1987 • 21 citations

Regulation of milk protein synthesis by progesterone in cultured mouse mammary gland

1988 • 21 citations

Effect of moderate vitamin A supplementation and lack of dietary vitamin A on the development of mammary tumors in female rats treated with low carcinogenic dose levels of 7,12-dimethylbenz(a)anthracene.

1986 • 21 citations

Hormonal control of milk protein synthesis in cultured mouse mammary explants

1977 • 20 citations

Effect of polypeptide hormones on stimulation of casein secretion by mouse mammary epithelial cells grown on floating collagen gels

1978 • 20 citations

Anticarcinogenic Effects of Retinoids in Animals

1986 • 20 citations

1,25-Dihydroxyvitamin D<sub>3</sub> Target Cells in Rat Mammary Gland

1981 • 20 citations

The Role of Prolactin in Normal Mammary Gland Growth and Function

1980 • 19 citations

Cyclic Nucleotides and Protein Phosphorylation in Mouse Mammary Glands: Effects of Estrogen and Progesterone Administered in Vivo

1987 • 19 citations

Influence of bromoergocryptine on estrogen-modulated prolactin receptors of mouse mammary gland

1978 • 19 citations

Effect of prolactin on lactalbumin production by normal and malignant human breast tissue in organ culture.

1980 • 19 citations

Effects of insulin, cortisol and prolactin on lipid, protein and casein syntheses in goat mammary tissue in organ culture

1982 • 19 citations

THE INDUCTION OF α-LACTALBUMIN IN RAT MAMMARY EXPLANTS IN THE ABSENCE OF EXOGENOUS PROLACTIN: EFFECTS OF PROGESTERONE AND ESTROGEN

1981 • 19 citations

N-Nitrosodiethylamine-induced nodule-like alveolar lesion and its prevention by a retinoid in BALB/c mouse mammary glands in the whole organ in culture

1982 • 18 citations

Subpopulations of cells in immature mouse mammary gland as detected by proliferative responses to hormones in organ culture

1984 • 18 citations

LACK OF MITOTIC EFFECTS OF INSULIN DURING SYNTHESIS OF CASEIN INDUCED BY PROLACTIN IN PSEUDOPREGNANT RABBIT MAMMARY GLAND ORGAN CULTURES

1977 • 17 citations

Hormonal regulation of casein messenger RNA (mRNA)

1978 • 17 citations

Renewal inhibition of human mammary cell growth in vitro: Cortisol and the recruitment of cells to terminal differentiation

1983 • 17 citations

Long-term explant culture of normal mammary epithelium.

1983 • 17 citations

Isolation, Characterization, and Regulation of the Prolactin Receptor

1985 • 17 citations

Measurement of alpha-lactalbumin in serum and mammary tumors of rats by radioimmunoassay.

1977 • 16 citations

The effect of ovarian and hypophyseal hormones on mammary gland epithelial cell proliferation

1964 • 15 citations

Effect of thymectomy on mammary tumorigenesis, noduligenesis, and mammogenesis in the mouse.

1967 • 15 citations

Hormonal Regulation of the Synthesis of Casein and α-Lactalbumin in a Primary Mammary Cell Culture System

1986 • 14 citations

Role of glucocorticoids and progesterone in the development of rough endoplasmic reticulum involved in casein biosynthesis

1979 • 14 citations

Human breast epithelium in organ culture: Effect of hormones on growth and morphology

1981 • 13 citations

Effects of peptides and steroid hormones on cell kinetic parameters of normal human breast tissue in organ culture

1986 • 13 citations

Hormonal Regulation of Protein Kinase C in the Mouse Mammary Gland

1986 • 12 citations

The regulatory function of spermidine in hormonal control of the development of mouse mammary gland in culture.

1982 • 12 citations

Effect of Vitamin A Deprivation on Maintenance of Rat Mammary Tissue and on the Potential of the Epithelium for Hormone-Dependent Milk Protein Synthesis

1982 • 11 citations

Effect of tubulozole, a new synthetic microtubule inhibitor, on the induction of casein gene expression by prolactin

1987 • 11 citations

Cell kinetics in normal and neoplastic mammary tissues by flow cytometric analyses

1985 • 10 citations

THE ONSET OF ALLOMETRIC MAMMARY GROWTH IN THE FEMALE HOODED NORWAY RAT

1953 • 10 citations

Influence of some dietary chemopreventive agents on the expression of functional differentiation of the mouse mammary glandin vitro

1987 • 10 citations

The reversal of cortisol-induced inhibition of alpha-lactalbumin production by prostaglandins in the mouse mammary gland in culture.

1982 • 9 citations

BINDING OF PROLACTIN TO THE RABBIT MAMMARY GLAND DURING PREGNANCY

1977 • 8 citations

Interaction of rat mammary epithelium with extracellular matrix components.

1984 • 8 citations

Effects of estrogen-depletion of rat casein gene expression

1984 • 8 citations

THE PROLIFERATIVE ACTION OF OESTRIOL

1980 • 8 citations

Hormonal control of casein synthesis in mammary explants from pregnant goats.

1982 • 8 citations

Transepithelial electrophysiology of cultured mouse mammary epithelium: sensitivity to prolactins

1981 • 7 citations

On the Development of Insulin Sensitivity by Mouse Mammary Gland in Vitro

1971 • 7 citations

Direct Influence of the Three Natural Estrogens on Human Mammary Gland In Vitro

1982 • 7 citations

The relation between adenosine diphosphate‐ribosylation and mammary gland differentiation

1985 • 7 citations

Enhanced Endocrine Sensitivity in Mouse Mammary Glands: Hormonal Requirements for Induction and Maintenance*

1984 • 6 citations

The interrelationships among poly(ADP-ribosyl)ation, DNA synthesis and mammary gland differentiation

1986 • 6 citations

Role of hormones on the induction of retinoic acid binding protein in mouse mammary gland organ culture

1985 • 5 citations

Thyroid Hormone-Binding Inhibitor in Normal, Pregnant, and Lactating Rat and Postmenopausal Human Breast Tissue*

1985 • 3 citations

[Process of destruction of the second inguinal pair of mammary buds in male mouse fetus].

1953 • 2 citations

[Estradiol-progesterone interaction in normal and pathological human breast cells].

1986 • 2 citations

Estriol-induced dose-dependent DNA synthesis in normal human mammary epithelium in vitro.

1980 • 2 citations

Cultivation of Adult Mouse Mammary Gland in Hormone-Enriched Synthetic Medium

1957 • 2 citations