Identification of Residues within the SHC Phosphotyrosine Binding/Phosphotyrosine Interaction Domain Crucial for Phosphopeptide Interaction

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.

1985 • 2,456 citations

Protein modules and signalling networks

1995 • 2,447 citations

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

1992 • 1,358 citations

Randomization of genes by PCR mutagenesis.

1992 • 1,056 citations

Modular binding domains in signal transduction proteins

1995 • 962 citations

Role of IRS-2 in insulin and cytokine signalling

1995 • 843 citations

An Alternative to SH2 Domains for Binding Tyrosine-Phosphorylated Proteins

1994 • 501 citations

SH2/SH3 signaling proteins

1994 • 457 citations

Phosphotyrosine-Dependent Interaction of SHC and Insulin Receptor Substrate 1 with the NPEY Motif of the Insulin Receptor via a Novel Non-SH2 Domain

1995 • 368 citations

A region in Shc distinct from the SH2 domain can bind tyrosine-phosphorylated growth factor receptors.

1994 • 334 citations

The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gamma.

1990 • 314 citations

Insulin-induced phosphorylation of the 46- and 52-kDa Shc proteins.

1993 • 308 citations

PTB Domain Binding to Signaling Proteins Through a Sequence Motif Containing Phosphotyrosine

1995 • 245 citations

Multiple cytokines induce the tyrosine phosphorylation of Shc and its association with Grb2 in hemopoietic cells.

1993 • 238 citations

The Phosphotyrosine Interaction Domain of SHC Recognizes Tyrosine-phosphorylated NPXY Motif

1995 • 175 citations

A conserved amino-terminal Shc domain binds to phosphotyrosine motifs in activated receptors and phosphopeptides

1995 • 174 citations

Shc Binding to Nerve Growth Factor Receptor Is Mediated by the Phosphotyrosine Interaction Domain

1995 • 138 citations

The Phosphotyrosine Interaction Domain of Shc Binds an LXNPXY Motif on the Epidermal Growth Factor Receptor

1995 • 137 citations

Epidermal growth factor-receptor mutant lacking the autophosphorylation sites induces phosphorylation of Shc protein and Shc-Grb2/ASH association and retains mitogenic activity.

1994 • 128 citations

Specificity of the PTB Domain of Shc for β Turn-forming Pentapeptide Motifs Amino-terminal to Phosphotyrosine

1995 • 103 citations

Potent SHC tyrosine phosphorylation by epidermal growth factor at low receptor density or in the absence of receptor autophosphorylation sites.

1994 • 52 citations

Autophosphorylation mutants of the EGF-receptor signal through auxiliary mechanisms involving SH2 domain proteins.

1994 • 44 citations

Analysis of the role of the Shc and Grb2 proteins in signal transduction by the v-ErbB protein.

1994 • 38 citations

[36] Use of tyrosine-phosphorylated proteins to screen bacterial expression libraries for SH2 domains

1995 • 6 citations