Differential Modulation of Androgen Receptor-mediated Transactivation by Smad3 and Tumor Suppressor Smad4

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

Transcriptional Activators of TGF-β Responses: Smads

1998 • 1,024 citations

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

1997 • 1,023 citations

Molecular Cloning of Human and Rat Complementary DNA Encoding Androgen Receptors

1988 • 908 citations

Receptor-associated Mad homologues synergize as effectors of the TGF-β response

1996 • 874 citations

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription

1998 • 789 citations

MADR2 Is a Substrate of the TGFβ Receptor and Its Phosphorylation Is Required for Nuclear Accumulation and Signaling

1996 • 740 citations

MADR1, a MAD-Related Protein That Functions in BMP2 Signaling Pathways

1996 • 710 citations

DPC4 gene in various tumor types.

1996 • 680 citations

A human Mad protein acting as a BMP-regulated transcriptional activator

1996 • 674 citations

Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells.

1996 • 627 citations

Intestinal Tumorigenesis in Compound Mutant Mice of both Dpc4(Smad4) and Apc Genes

1998 • 603 citations

The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase.

1997 • 569 citations

A Smad Transcriptional Corepressor

1999 • 563 citations

The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGF-β-induced transcriptional activation

1998 • 527 citations

The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo

1998 • 494 citations

Xenopus Mad Proteins Transduce Distinct Subsets of Signals for the TGFβ Superfamily

1996 • 432 citations

p300 and p300/cAMP-response Element-binding Protein-associated Factor Acetylate the Androgen Receptor at Sites Governing Hormone-dependent Transactivation

2000 • 389 citations

Transforming growth factor β-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells

1997 • 357 citations

Cloning and Characterization of Androgen Receptor Coactivator, ARA55, in Human Prostate

1999 • 290 citations

Cross-talk between Transforming Growth Factor-β and Estrogen Receptor Signaling through Smad3

2001 • 250 citations

Progression of colorectal cancer is associated with multiple tumor suppressor gene defects but inhibition of tumorigenicity is accomplished by correction of any single defect via chromosome transfer.

1992 • 237 citations

The Linkage of Kennedy's Neuron Disease to ARA24, the First Identified Androgen Receptor Polyglutamine Region-associated Coactivator

1999 • 224 citations

Cloning and Characterization of Human Prostate Coactivator ARA54, a Novel Protein That Associates with the Androgen Receptor

1999 • 223 citations

Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells

1998 • 203 citations

SMAD3 represses androgen receptor-mediated transcription.

2001 • 194 citations

Ski acts as a co-repressor with Smad2 and Smad3 to regulate the response to type β transforming growth factor

2000 • 187 citations

The Smad4 Activation Domain (SAD) Is a Proline-rich, p300-dependent Transcriptional Activation Domain

2000 • 177 citations

Glucocorticoid receptor inhibits transforming growth factor-β signaling by directly targeting the transcriptional activation function of Smad3

1999 • 169 citations

Increase of androgen-induced cell death and androgen receptor transactivation by BRCA1 in prostate cancer cells

2000 • 154 citations

Characterization of Functional Domains within Smad4/DPC4

1997 • 151 citations

From transforming growth factor-β signaling to androgen action: Identification of Smad3 as an androgen receptor coregulator in prostate cancer cells

2001 • 151 citations

Isolation and Characterization of ARA160 as the First Androgen Receptor N-terminal-associated Coactivator in Human Prostate Cells

1999 • 143 citations

Retinoblastoma, a Tumor Suppressor, Is a Coactivator for the Androgen Receptor in Human Prostate Cancer DU145 Cells

1998 • 135 citations

The Smad transcriptional corepressor TGIF recruits mSin3.

2001 • 132 citations

Comparative mutational analysis of DPC4 (Smad4) in prostatic and colorectal carcinomas

1997 • 126 citations

Increased smad expression and activation are associated with apoptosis in normal and malignant prostate after castration.

1999 • 116 citations

From Androgen Receptor to the General Transcription Factor TFIIH

2000 • 115 citations

Smad Transcriptional Corepressors in TGFβ Family Signaling

2001 • 109 citations

Cross-talk between 1,25-Dihydroxyvitamin D3 and Transforming Growth Factor-β Signaling Requires Binding of VDR and Smad3 Proteins to Their Cognate DNA Recognition Elements

2001 • 92 citations

G ₁ cell cycle arrest and apoptosis induction by nuclear Smad4/Dpc4: Phenotypes reversed by a tumorigenic mutation

1999 • 83 citations

Ski-interacting Protein Interacts with Smad Proteins to Augment Transforming Growth Factor-β-dependent Transcription

2001 • 80 citations

5′TG3′ Interacting Factor Interacts with Sin3A and Represses AR-Mediated Transcription

2001 • 48 citations

An Essential Role for Mad Homology Domain 1 in the Association of Smad3 with Histone Deacetylase Activity*

2001 • 39 citations

Inhibition of Histone Deacetylation Augments Dihydrotestosterone Induction of Androgen Receptor Levels: An Explanation for Trichostatin A Effects on Androgen-Induced Chromatin Remodeling and Transcription of the Mouse Mammary Tumor Virus Promoter

1999 • 24 citations