Gene expression, cellular diversification and tumor progression to the metastatic phenotype

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

The Clonal Evolution of Tumor Cell Populations

1976 • 6,310 citations

Somatic generation of antibody diversity

1983 • 3,275 citations

Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation

1991 • 2,774 citations

Evidence for a Novel Gene Associated With Low Tumor Metastatic Potential

1988 • 1,304 citations

Tumor cell instability, diversification, and progression to the metastatic phenotype: from oncogene to oncofetal expression.

1987 • 508 citations

Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development

1989 • 487 citations

Antisense RNA-Induced Reduction in Murine TIMP Levels Confers Oncogenicity on Swiss 3T3 Cells

1989 • 459 citations

Association of low nm23 RNA levels in human primary infiltrating ductal breast carcinomas with lymph node involvement and other histopathological indicators of high metastatic potential.

1989 • 398 citations

Alterations of myc , myb , and ras ^Ha Proto-Oncogenes In Cancers Are Frequent and Show Clinical Correlation

1986 • 379 citations

Transgenic Mice as Probes into Complex Systems

1989 • 368 citations

Conditioned tumorigenicity of activated oncogenes.

1986 • 173 citations

Expression of H-ras correlates with metastatic potential: evidence for direct regulation of the metastatic phenotype in 10T1/2 and NIH 3T3 cells.

1987 • 163 citations

Isolation and characterization of a cDNA clone encoding rat nucleoside diphosphate kinase.

1990 • 158 citations

Alteration of the tumorigenic and metastatic properties of neoplastic cells is associated with the process of calcium phosphate-mediated DNA transfection.

1987 • 120 citations

The differential expression of H‐2K versus H‐2D antigens, distinguishing high‐ metastatic from low‐ metastatic clones, is correlated with the immunogenic properties of the tumor cells

1984 • 108 citations

Clonal dominance of primary tumours by metastatic cells: genetic analysis and biological implications.

1988 • 105 citations

Neoplastic Development 2

1975 • 104 citations

Differential expression of a novel gene, WDNM1, in nonmetastatic rat mammary adenocarcinoma cells.

1988 • 93 citations

Metastasis Suppressor Genes

1990 • 75 citations

The significance of biological heterogeneity

1990 • 73 citations

Cellular interactions in metastasis

1990 • 72 citations

Tumorigenicity of embryonal carcinoma as an assay to study control of malignancy by the murine blastocyst.

1979 • 62 citations

Invasion: Experimental and Clinical Implications

1985 • 62 citations

Genetic instability of cancer

1988 • 54 citations

The use of cell fusion to analyse factors involved in tumour cell metastasis

1983 • 52 citations

Cell fusion segregates progressive growth from metastasis

1983 • 48 citations

Transcriptional down-regulation of a rat gene, WDNM2, in metastatic DMBA-8 cells.

1989 • 43 citations

Role of oncogenes in metastases

1988 • 43 citations

Oncogenes and metastatic progression.

1989 • 43 citations

Relationship between metastatic ability and H-ras oncogene expression in rat mammary cancer cells transfected with the v-H-ras oncogene.

1990 • 27 citations

Lack of correlation between intercellular junctional communication, p21rasEJ expression, and spontaneous metastatic properties of rat mammary cells after transfection with c-H-rasEJ or neo genes.

1990 • 27 citations

Structure of gene mts1, transcribed in metastatic mouse tumor cells

1990 • 26 citations

Oncogene transformation and the metastatic phenotype.

1988 • 26 citations

Gene expression and tumor cell escape from host effector mechanisms in murine large cell lymphoma

1988 • 22 citations

DNA amplification and metastasis of the human melanoma cell line MeWo.

1987 • 21 citations

ras Transfection and expression does not induce progression from tumorigenicity to metastatic ability in mouse LTA cells

1990 • 21 citations

Transient alterations in the expression of protease and extracellular matrix genes during metastatic lung colonization by H-ras-transformed 10T1/2 fibroblasts.

1990 • 18 citations

Oncogenes and tumor progression.

1989 • 18 citations

c‐fos transfection of 3LL tumor cells turns on MHC gene expression and consequently reduces their metastatic competence

1990 • 14 citations

Transformation injury and the unicellular phenotype of malignant cells

1990 • 11 citations

Diversification and progression of malignant tumors

1987 • 8 citations