Differential Roles for αMβ2 Integrin Clustering or Activation in the Control of Apoptosis via Regulation of Akt and ERK Survival Mechanisms

Cellular survival: a play in three Akts

1999 • 4,229 citations

Integrin Signaling

1999 • 3,705 citations

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.

1998 • 3,085 citations

Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

1998 • 2,505 citations

Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages.

1989 • 1,540 citations

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses

1993 • 1,148 citations

A New Method for the Cytofluorometric Analysis of Mitochondrial Membrane Potential Using the J-Aggregate Forming Lipophilic Cation 5,5′,6,6′-Tetrachloro-1,1′,3,3′-tetraethylbenzimidazolcarbocyanine Iodide (JC-1)

1993 • 1,015 citations

Modulation of multiple neutrophil functions by preparative methods or trace concentrations of bacterial lipopolysaccharide.

1985 • 796 citations

A Novel Role for the β2 Integrin CD11b/CD18 in Neutrophil Apoptosis: A Homeostatic Mechanism in Inflammation

1996 • 645 citations

Akt/Protein Kinase B Inhibits Cell Death by Preventing the Release of Cytochrome c from Mitochondria

1999 • 642 citations

Mechanics of Stimulated Neutrophils: Cell Stiffening Induces Retention in Capillaries

1989 • 612 citations

Cytokine-induced respiratory burst of human neutrophils: dependence on extracellular matrix proteins and CD11/CD18 integrins.

1989 • 577 citations

Differential expression of Fas (CD95) and Fas ligand on normal human phagocytes: implications for the regulation of apoptosis in neutrophils.

1996 • 574 citations

The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands.

1993 • 546 citations

A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen.

1993 • 523 citations

Regulation of Bad Phosphorylation and Association with Bcl-xL by the MAPK/Erk Kinase

1999 • 385 citations

Mcl-1 Expression in Human Neutrophils: Regulation by Cytokines and Correlation With Cell Survival

1998 • 349 citations

SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival

1999 • 344 citations

B-Raf Inhibits Programmed Cell Death Downstream of Cytochrome c Release from Mitochondria by Activating the MEK/Erk Pathway

1999 • 311 citations

Oxidative Stress Disrupts Insulin-induced Cellular Redistribution of Insulin Receptor Substrate-1 and Phosphatidylinositol 3-Kinase in 3T3-L1 Adipocytes

1999 • 307 citations

A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration

1998 • 283 citations

p38 Mitogen-activated Protein Kinase-dependent and -independent Intracellular Signal Transduction Pathways Leading to Apoptosis in Human Neutrophils

1998 • 282 citations

Regulation of leukocyte integrin function: Affinity vs. avidity

1996 • 244 citations

Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress

1998 • 209 citations

Neutrophil apoptosis is modulated by endothelial transmigration and adhesion molecule engagement.

1997 • 208 citations

Mechanisms of Acute Eosinophil Mobilization from the Bone Marrow Stimulated by Interleukin 5: The Role of Specific Adhesion Molecules and Phosphatidylinositol 3-Kinase

1998 • 204 citations

Biochemistry and Physiology of the Neutrophil

1994 • 203 citations

Biochemistry and Physiology of the Neutrophil

1994 • 189 citations

PTEN Gene and Integrin Signaling in Cancer

1999 • 186 citations

The native structure of intercellular adhesion molecule-1 (ICAM-1) is a dimer. Correlation with binding to LFA-1.

1995 • 177 citations

Bcl-Xl– and Bax-–Mediated Regulation of Apoptosis of Human Neutrophils Via Caspase-3

1999 • 174 citations

Insulin Signaling Is Inhibited by Micromolar Concentrations of H2O2

1999 • 174 citations

FMLP activates Ras and Raf in human neutrophils. Potential role in activation of MAP kinase.

1994 • 167 citations

Occupancy of CD11b/CD18 (Mac-1) divalent ion binding site(s) induces leukocyte adhesion.

1991 • 154 citations

Rapid acceleration of neutrophil apoptosis by tumor necrosis factor-α

1993 • 149 citations

Two Signaling Mechanisms for Activation of αMβ2 Avidity in Polymorphonuclear Neutrophils

1998 • 140 citations

Integrin signal transduction in myeloid leukocytes

1999 • 134 citations

Regulation of MCL1 through a Serum Response Factor/Elk-1-mediated Mechanism Links Expression of a Viability-promoting Member of the BCL2 Family to the Induction of Hematopoietic Cell Differentiation

1999 • 122 citations

A role for β ₂ integrins (CD11/CD18) in the regulation of cytokine gene expression of polymorphonuclear neutrophils during the inflammatory response

1999 • 102 citations

A1 Is a Constitutive and Inducible Bcl-2 Homologue in Mature Human Neutrophils

1998 • 101 citations

Tyrosine Phosphorylation and Relocation of SHIP Are Integrin-mediated in Thrombin-stimulated Human Blood Platelets

1997 • 99 citations

β ₂ integrins (CD11/CD18) promote apoptosis of human neutrophils

1997 • 98 citations

Augmented Intracellular Glutathione Inhibits Fas-Triggered Apoptosis of Activated Human Neutrophils

1997 • 97 citations

Granulocyte activation via a binding site near the C-terminal region of complement receptor type 3 alpha-chain (CD11b) potentially involved in intramembrane complex formation with glycosylphosphatidylinositol-anchored Fc gamma RIIIB (CD16) molecules.

1995 • 78 citations

Protection from apoptosis in human neutrophils is determined by the surface of adhesion

1997 • 64 citations

Engagement of alpha4beta7 integrins by monoclonal antibodies or ligands enhances survival of human eosinophils in vitro.

1999 • 61 citations

Engagement of α4β7 Integrins by Monoclonal Antibodies or Ligands Enhances Survival of Human Eosinophils In Vitro

1999 • 58 citations

Extracellular matrix regulates apoptosis in human neutrophils

1999 • 44 citations

Low-affinity LFA-1/ICAM-3 interactions augment LFA-1/ICAM-1-mediated T cell adhesion and signaling by redistribution of LFA-1

2000 • 40 citations

β2-Integrins mediate stable adhesion in collisional interactions between neutrophils and ICAM-1-expressing cells

1998 • 39 citations

MAP-Kinase Dependent Induction of Monocytic Procoagulant Activity by β2-Integrins

1998 • 25 citations