Low-affinity LFA-1/ICAM-3 interactions augment LFA-1/ICAM-1-mediated T cell adhesion and signaling by redistribution of LFA-1

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Adhesion receptors of the immune system

1990 • 6,585 citations

Integrins and Signal Transduction Pathways: the Road Taken

1995 • 3,002 citations

Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1).

1986 • 2,490 citations

Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1)

1987 • 1,712 citations

T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

1989 • 1,587 citations

A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1.

1986 • 1,428 citations

Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families

1988 • 967 citations

A human leukocyte differentiation antigen family with distinct alpha-subunits and a common beta-subunit: the lymphocyte function-associated antigen (LFA-1), the C3bi complement receptor (OKM1/Mac-1), and the p150,95 molecule.

1983 • 888 citations

Functional cloning of ICAM-2, a cell adhesion ligand for LFA-1 homologous to ICAM-1

1989 • 837 citations

Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3.

1982 • 740 citations

ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM

1988 • 631 citations

The functional significance, distribution, and structure of LFA-1, LFA-2, and LFA-3: cell surface antigens associated with CTL-target interactions.

1983 • 583 citations

Characterization of ICAM-2 and evidence for a third counter-receptor for LFA-1.

1991 • 510 citations

Divalent cation regulation of the function of the leukocyte integrin LFA-1.

1992 • 492 citations

The requirement for lymphocyte function-associated antigen 1 in homotypic leukocyte adhesion stimulated by phorbol ester.

1986 • 487 citations

Enhancement of LFA-1-mediated cell adhesion by triggering through CD2 or CD3 on T lymphocytes

1989 • 482 citations

Intercellular adhesion molecule 3, a third adhesion counter-receptor for lymphocyte function-associated molecule 1 on resting lymphocytes.

1992 • 437 citations

Leukocyte Migration and Adhesion

1995 • 365 citations

Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes

1992 • 350 citations

Adhesion-activating phorbol ester increases the mobility of leukocyte integrin LFA-1 in cultured lymphocytes.

1996 • 343 citations

Regulated expression of Mg2+ binding epitope on leukocyte integrin alpha subunits.

1989 • 321 citations

Assembly of focal adhesions: progress, paradigms, and portents

1996 • 265 citations

Ins and outs of LFA-1

1995 • 260 citations

A novel leukointegrin, αdβ2, binds preferentially to ICAM-3

1995 • 255 citations

A monoclonal antibody (NKI-L16) directed against a unique epitope on the alpha-chain of human leukocyte function-associated antigen 1 induces homotypic cell-cell interactions.

1988 • 248 citations

Regulation of leukocyte integrin function: Affinity vs. avidity

1996 • 244 citations

Activation of LFA-1 through a Ca2(+)-dependent epitope stimulates lymphocyte adhesion.

1991 • 223 citations

Antibody against the Leu-CAM beta-chain (CD18) promotes both LFA-1- and CR3-dependent adhesion events.

1992 • 223 citations

LFA-1 and other accessory molecules functioning in adhesions of T and B lymphocytes

1987 • 223 citations

A functional integrin ligand on the surface of platelets: intercellular adhesion molecule-2.

1994 • 220 citations

Cloning and characterization of a new intercellular adhesion molecule ICAM-R

1992 • 210 citations

On the mode of action of LFA-1

1990 • 208 citations

Focal contacts: Transmembrane links between the extracellular matrix and the cytoskeleton

1989 • 193 citations

Activation of human neutrophils induces an interaction between the integrin beta 2-subunit (CD18) and the actin binding protein alpha-actinin.

1993 • 187 citations

Characterization of the function of intercellular adhesion molecule (ICAM)-3 and comparison with ICAM-1 and ICAM-2 in immune responses.

1994 • 172 citations

ICAM-3 interacts with LFA-1 and regulates the LFA-1/ICAM-1 cell adhesion pathway.

1993 • 170 citations

Dual role of the actin cytoskeleton in regulating cell adhesion mediated by the integrin lymphocyte function-associated molecule-1.

1997 • 166 citations

The Actin Cytoskeleton Regulates LFA-1 Ligand Binding through Avidity Rather than Affinity Changes

1999 • 165 citations

Biochemical and functional characteristics of the human leukocyte membrane antigen family LFA‐1, Mo‐1 and p!50,95

1985 • 162 citations

Characterization of Monoclonal Antibodies Against Cell Surface Molecules Associated with Cytotoxic Activity of Natural and Activated Killer Cells and Cloned CTL Lines

1983 • 155 citations

Extracellular Ca2+ modulates leukocyte function-associated antigen-1 cell surface distribution on T lymphocytes and consequently affects cell adhesion

1994 • 148 citations

A novel LFA-1 activation epitope maps to the I domain.

1993 • 136 citations

KIM185, a monoclonal antibody to CD18 which induces a change in the conformation of CD18 and promotes both LFA‐1‐ and CR3‐dependent adhesion

1993 • 127 citations

Cloning and expression of intercellular adhesion molecule 3 reveals strong homology to other immunoglobulin family counter-receptors for lymphocyte function-associated antigen 1.

1993 • 115 citations

Involvement of the "I" domain of LFA-1 in selective binding to ligands ICAM-1 and ICAM-3.

1994 • 102 citations

Ligand intercellular adhesion molecule 1 has a necessary role in activation of integrin lymphocyte function-associated molecule 1.

1993 • 101 citations

ICAM‐3, the third LFA‐1 counterreceptor, is a co‐stimulatory molecule for both resting and activated T lymphocytes

1993 • 100 citations

Induction of tyrosine phosphorylation during ICAM-3 and LFA-1-mediated intercellular adhesion, and its regulation by the CD45 tyrosine phosphatase.

1994 • 98 citations

Distinct binding of T lymphocytes to ICAM‐1, ‐2 or ‐3 upon activation of LFA‐1

1994 • 94 citations

Distribution of ICAM-3-bearing cells in normal human tissues. Expression of a novel counter-receptor for LFA-1 in epidermal Langerhans cells.

1993 • 84 citations

Intercellular adhesion molecule‐3 is the predominant co‐stimulatory ligand for leukocyte function antigen‐1 on human blood dendritic cells

1995 • 81 citations

Lymphocyte function-associated antigen 1 dominates very late antigen 4 in binding of activated T cells to endothelium.

1993 • 76 citations

CD50 (intercellular adhesion molecule 3) stimulation induces calcium mobilization and tyrosine phosphorylation through p59fyn and p56lck in Jurkat T cell line.

1994 • 63 citations

Signaling through CD50 (ICAM‐3) stimulates T lymphocyte binding to human umbilical vein endothelial cells and extracellular matrix proteins via an increase in β1 and β2 integrin function

1994 • 55 citations

Cytoplasmic tails of beta 1, beta 2, and beta 7 integrins differentially regulate LFA-1 function in K562 cells.

1997 • 54 citations

How LFA-1 binds to different ligands

1999 • 53 citations

Co-stimulation of T cells results in distinct IL-10 and TNF-α cytokine profiles dependent on binding to ICAM-1, ICAM-2 or ICAM-3

1999 • 47 citations

Critical amino acids in the lymphocyte function-associated antigen-1 I domain mediate intercellular adhesion molecule 3 binding and immune function.

1996 • 44 citations

Antibodies That Selectively Inhibit Leukocyte Function-associated Antigen 1 Binding to Intercellular Adhesion Molecule-3 Recognize a Unique Epitope within the CD11a I Domain

1996 • 37 citations

Cellular distribution of human leucocyte adhesion molecule ICAM-3.

1994 • 31 citations

A centrifugal elutriation system of separating small numbers of cells

1984 • 26 citations

Lymphocyte Migration: A new spin on lymphocyte homing

1995 • 17 citations

Role of ligands in the activation of LFA‐1

1997 • 16 citations

Role of ICAM-3 in Intercellular Adhesion and Activation of T Lymphocytes

1994 • 9 citations

Quality control of anti human CD3 and CD4 monoclonal antibodies.

1990 • 8 citations

Lymphocyte adhesion mediated by integrins

1993 • 6 citations

Quality control of anti human CD3 and CD4 monoclonal antibodies.

1990 • 5 citations