Effects of amino acid changes in the extracellular domain of the human immunodeficiency virus type 1 gp41 envelope glycoprotein

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)

1983 • 6,811 citations

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

Frequent Detection and Isolation of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and at Risk for AIDS

1984 • 3,647 citations

The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus

1984 • 3,530 citations

T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV

1984 • 2,441 citations

The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain

1986 • 2,020 citations

THE STRUCTURE AND FUNCTION OF THE HEMAGGLUTININ MEMBRANE GLYCOPROTEIN OF INFLUENZA VIRUS

1987 • 1,391 citations

Protein Oligomerization in the Endoplasmic Reticulum

1989 • 993 citations

Binding of HTLV-III/LAV to T4 ⁺ T Cells by a Complex of the 110K Viral Protein and the T4 Molecule

1986 • 988 citations

Functional Regions of the Envelope Glycoprotein of Human Immunodeficiency Virus Type 1

1987 • 883 citations

Expression of wild-type and mutant forms of influenza hemagglutinin: The role of folding in intracellular transport

1986 • 879 citations

Acquired Immunodeficiency Syndrome: Epidemiologic, Clinical, Immunologic, and Therapeutic Considerations

1984 • 871 citations

Delineation of a region of the human immunodeficiency virus type 1 gp120 glycoprotein critical for interaction with the CD4 receptor

1987 • 827 citations

Role of the HTLV-III/LAV envelope in syncytium formation and cytopathicity

1986 • 804 citations

A second post-transcriptional trans-activator gene required for HTLV-III replication

1986 • 639 citations

Principal neutralizing domain of the human immunodeficiency virus type 1 envelope protein.

1989 • 628 citations

Antibodies that inhibit fusion of human immunodeficiency virus-infected cells bind a 24-amino acid sequence of the viral envelope, gp120.

1988 • 626 citations

pH-independent HIV entry into CD4-positive T cells via virus envelope fusion to the plasma membrane

1987 • 620 citations

Dissociation of gp120 from HIV-1 Virions Induced by Soluble CD4

1990 • 598 citations

Conformational changes induced in the human immunodeficiency virus envelope glycoprotein by soluble CD4 binding.

1991 • 598 citations

Induction of CD4-dependent cell fusion by the HTLV-III/LAV envelope glycoprotein

1986 • 593 citations

Major Glycoprotein Antigens That Induce Antibodies in AIDS Patients Are Encoded by HTLV-III

1985 • 583 citations

Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains

1990 • 549 citations

Crystal structure of an HIV-binding recombinant fragment of human CD4

1990 • 545 citations

Viral and Cellular Membrane Fusion Proteins

1990 • 517 citations

Biosynthesis, cleavage, and degradation of the human immunodeficiency virus 1 envelope glycoprotein gp160.

1988 • 442 citations

Characterization of gp41 as the Transmembrane Protein Coded by the HTLV-III/LAV Envelope Gene

1985 • 442 citations

Regulation of Protein Export From the Endoplasmic Reticulum

1988 • 421 citations

Oligomerization is essential for transport of vesicular stomatitis viral glycoprotein to the cell surface

1986 • 417 citations

Characterization of a human immunodeficiency virus neutralizing monoclonal antibody and mapping of the neutralizing epitope

1988 • 412 citations

Identification of individual human immunodeficiency virus type 1 gp120 amino acids important for CD4 receptor binding

1990 • 407 citations

A General Model for the Transmembrane Proteins of HIV and Other Retroviruses

1989 • 375 citations

Identification of the residues in human CD4 critical for the binding of HIV

1989 • 357 citations

Characterization of Envelope and Core Structural Gene Products of HTLV-III with Sera from AIDS Patients

1985 • 356 citations

Characterization of the fusion domain of the human immunodeficiency virus type 1 envelope glycoprotein gp41.

1990 • 348 citations

HTLV-III/LAV-Neutralizing Antibodies to anE. coli-Produced Fragment of the Virus Envelope

1986 • 336 citations

Folding, interaction with GRP78-BiP, assembly, and transport of the human immunodeficiency virus type 1 envelope protein

1991 • 333 citations

Human immunodeficiency virus type 1 gp120 envelope glycoprotein regions important for association with the gp41 transmembrane glycoprotein

1991 • 295 citations

Genetic analysis of monoclonal antibody and HIV binding sites on the human lymphocyte antigen CD4

1988 • 294 citations

Oligomeric structure of gp41, the transmembrane protein of human immunodeficiency virus type 1

1989 • 294 citations

Binding of the human retrovirus HTLV-III/LAV/ARV/HIV to the CD4 (T4) molecule: conformation dependence, epitope mapping, antibody inhibition, and potential for idiotypic mimicry.

1986 • 293 citations

Virions of primary human immunodeficiency virus type 1 isolates resistant to soluble CD4 (sCD4) neutralization differ in sCD4 binding and glycoprotein gp120 retention from sCD4-sensitive isolates

1992 • 287 citations

Protein-Mediated Membrane Fusion

1989 • 279 citations

The envelope glycoprotein of the human immunodeficiency virus binds to the immunoglobulin-like domain of CD4

1988 • 277 citations

Single amino-acid changes in HIV envelope affect viral tropism and receptor binding

1989 • 270 citations

Rapid complementation assays measuring replicative potential of human immunodeficiency virus type 1 envelope glycoprotein mutants

1990 • 268 citations

An IgG human monoclonal antibody that reacts with HIV-1/GP120, inhibits virus binding to cells, and neutralizes infection.

1991 • 262 citations

Identification of the principal neutralizing determinant of human immunodeficiency virus type 1 as a fusion domain

1991 • 219 citations

Binding of soluble CD4 proteins to human immunodeficiency virus type 1 and infected cells induces release of envelope glycoprotein gp120.

1991 • 211 citations

Mutations in the leucine zipper of the human immunodeficiency virus type 1 transmembrane glycoprotein affect fusion and infectivity

1992 • 192 citations

Intracellular processing of the gp160 HIV-1 envelope precursor. Endoproteolytic cleavage occurs in a cis or medial compartment of the Golgi complex.

1990 • 190 citations

Human immunodeficiency virus envelope glycoprotein/CD4-mediated fusion of nonprimate cells with human cells

1990 • 185 citations

Effects of deletions in the cytoplasmic domain on biological functions of human immunodeficiency virus type 1 envelope glycoproteins

1992 • 182 citations

Mapping the CD4 binding site for human immunodeficiency virus by alanine-scanning mutagenesis.

1990 • 179 citations

Direct measurement of soluble CD4 binding to human immunodeficiency virus type 1 virions: gp120 dissociation and its implications for virus-cell binding and fusion reactions and their neutralization by soluble CD4

1991 • 178 citations

Location and Chemical Synthesis of a Binding Site for HIV-1 on the CD4 Protein

1988 • 178 citations

Substitution of murine for human CD4 residues identifies amino acids critical for HIV-gp120 binding

1988 • 175 citations

Oligomeric structure of a prototype retrovirus glycoprotein.

1988 • 155 citations

Binding region for human immunodeficiency virus (HIV) and epitopes for HIV-blocking monoclonal antibodies of the CD4 molecule defined by site-directed mutagenesis.

1988 • 150 citations

Enhancement of SIV Infection with Soluble Receptor Molecules

1990 • 136 citations

Analysis of the site in CD4 that binds to the HIV envelope glycoprotein.

1990 • 132 citations

Attenuation of human immunodeficiency virus type 1 cytopathic effect by a mutation affecting the transmembrane envelope glycoprotein

1991 • 125 citations

Changes in the transmembrane region of the human immunodeficiency virus type 1 gp41 envelope glycoprotein affect membrane fusion

1990 • 124 citations

A soluble recombinant polypeptide comprising the amino-terminal half of the extracellular region of the CD4 molecule contains an active binding site for human immunodeficiency virus.

1988 • 120 citations

Analysis of mutations in the V3 domain of gp160 that affect fusion and infectivity

1992 • 120 citations

Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1.

1989 • 106 citations

Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport

1989 • 103 citations

Effects of changes in gp120-CD4 binding affinity on human immunodeficiency virus type 1 envelope glycoprotein function and soluble CD4 sensitivity

1991 • 101 citations

Target cell-specific determinants of membrane fusion within the human immunodeficiency virus type 1 gp120 third variable region and gp41 amino terminus

1992 • 101 citations

Model for intracellular folding of the human immunodeficiency virus type 1 gp120

1989 • 95 citations

Alteration of HIV-1 Infectivity and Neutralization by a Single Amino Acid Replacement in the V3 Loop Domain

1991 • 94 citations

Mutations in the principal neutralization determinant of human immunodeficiency virus type 1 affect syncytium formation, virus infectivity, growth kinetics, and neutralization

1992 • 93 citations

Lack of correlation between soluble CD4-induced shedding of the human immunodeficiency virus type 1 exterior envelope glycoprotein and subsequent membrane fusion events

1992 • 87 citations

Stimulation of glycoprotein gp120 dissociation from the envelope glycoprotein complex of human immunodeficiency virus type 1 by soluble CD4 and CD4 peptide derivatives: implications for the role of the complementarity-determining region 3-like region in membrane fusion.

1991 • 63 citations

Effects of mutations in hyperconserved regions of the extracellular glycoprotein of human immunodeficiency virus type 1 on receptor binding

1989 • 61 citations

Mutational analysis of conserved N-linked glycosylation sites of human immunodeficiency virus type 1 gp41

1992 • 51 citations

Human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus env proteins possess a functionally conserved assembly domain

1990 • 48 citations

Functional roles of the V3 hypervariable region of HIV-1 gp160 in the processing of gp160 and in the formation of syncytia in CD4+ cells

1992 • 44 citations

Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules.

1990 • 43 citations

The transmembrane glycoprotein of human immunodeficiency virus type 1 induces syncytium formation in the absence of the receptor binding glycoprotein

1992 • 39 citations

Role of asparagine-linked glycosylation in human immunodeficiency virus type 1 transmembrane envelope function

1992 • 35 citations

Identification of Membrane Anchorage Domains of the HIV-1 gp160 Envelope Glycoprotein Precursor

1991 • 33 citations

Human immunodeficiency virus type 1 envelope glycoprotein molecules containing membrane fusion-impairing mutations in the V3 region efficiently undergo soluble CD4-stimulated gp120 release

1992 • 27 citations

Contribution of charged amino acids in the CDR2 region of CD4 to HIV-1 gp120 binding.

1992 • 18 citations

Transport of Membrane Proteins to the Cell Surface

1991 • 18 citations