Human AML1/MDS1/EVI1 fusion protein induces an acute myelogenous leukemia (AML) in mice: A model for human AML

AML1, the Target of Multiple Chromosomal Translocations in Human Leukemia, Is Essential for Normal Fetal Liver Hematopoiesis

1996 • 1,885 citations

t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1.

1991 • 897 citations

Fusion Between Transcription Factor CBFβ/PEBP2β and a Myosin Heavy Chain in Acute Myeloid Leukemia

1993 • 760 citations

Efficient and Rapid Induction of a Chronic Myelogenous Leukemia-Like Myeloproliferative Disease in Mice Receiving P210 bcr/abl-Transduced Bone Marrow

1998 • 756 citations

Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia.

1995 • 738 citations

The CBFβ Subunit Is Essential for CBFα2 (AML1) Function In Vivo

1996 • 630 citations

The P190, P210, and P230 Forms of the BCR/ABL Oncogene Induce a Similar Chronic Myeloid Leukemia–like Syndrome in Mice but Have Different Lymphoid Leukemogenic Activity

1999 • 503 citations

High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia

1995 • 454 citations

Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell lines

1988 • 417 citations

Expression of a Knocked-In AML1-ETO Leukemia Gene Inhibits the Establishment of Normal Definitive Hematopoiesis and Directly Generates Dysplastic Hematopoietic Progenitors

1998 • 362 citations

Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene

1997 • 362 citations

AML1 and the 8;21 and 3;21 translocations in acute and chronic myeloid leukemia

1995 • 346 citations

Failure of Embryonic Hematopoiesis andLethal Hemorrhages in Mouse Embryos Heterozygousfor a Knocked-In Leukemia Gene CBFB–MYH11

1996 • 296 citations

Bcr-Abl Efficiently Induces a Myeloproliferative Disease and Production of Excess Interleukin-3 and Granulocyte-Macrophage Colony-Stimulating Factor in Mice: A Novel Model for Chronic Myelogenous Leukemia

1998 • 284 citations

Expression of a Knocked-In AML1-ETO Leukemia Gene Inhibits the Establishment of Normal Definitive Hematopoiesis and Directly Generates Dysplastic Hematopoietic Progenitors

1998 • 280 citations

Consistent intergenic splicing and production of multiple transcripts between AML1 at 21q22 and unrelated genes at 3q26 in (3;21)(q26;q22) translocations.

1994 • 272 citations

Identification of a common ecotropic viral integration site, Evi-1, in the DNA of AKXD murine myeloid tumors.

1988 • 203 citations

Intergenic splicing of MDS1 and EVI1 occurs in normal tissues as well as in myeloid leukemia and produces a new member of the PR domain family.

1996 • 200 citations

Hematopoiesis in the fetal liver is impaired by targeted mutagenesis of a gene encoding a non-DNA binding subunit of the transcription factor, polyomavirus enhancer binding protein 2/core binding factor

1997 • 190 citations

The Reliability and Specificity of c-kit for the Diagnosis of Acute Myeloid Leukemias and Undifferentiated Leukemias

1998 • 187 citations

The 3;21 translocation in myelodysplasia results in a fusion transcript between the AML1 gene and the gene for EAP, a highly conserved protein associated with the Epstein-Barr virus small RNA EBER 1.

1993 • 179 citations

Associations between morphology, karyotype, and clinical features in myeloid leukemias

1987 • 154 citations

The EVI1 gene in myeloid leukemia

1997 • 126 citations

Loss of erythropoietin responsiveness in erythroid progenitors due to expression of the Evi-1 myeloid-transforming gene.

1993 • 124 citations

Expression of the Evi-1 Zinc Finger Gene in 32Dcl3 Myeloid Cells Blocks Granulocytic Differentiation in Response to Granulocyte Colony-Stimulating Factor

1992 • 120 citations

MDS1/EVI1 enhances TGF-β1 signaling and strengthens its growth-inhibitory effect, but the leukemia-associated fusion protein AML1/MDS1/EVI1, product of the t(3;21), abrogates growth-inhibition in response to TGF-β1

1999 • 110 citations

Dual Functions of the AML1/Evi-1 Chimeric Protein in the Mechanism of Leukemogenesis in t(3;21) Leukemias

1995 • 108 citations

The PEBP2 β MYH11 fusion created by Inv(16)(p13;q22) in myeloid leukemia impairs neutrophil maturation and contributes to granulocytic dysplasia

1998 • 72 citations

Bcr-Abl with an SH3 Deletion Retains the Ability To Induce a Myeloproliferative Disease in Mice, yet c-Abl Activated by an SH3 Deletion Induces Only Lymphoid Malignancy

1999 • 67 citations

Expression of the C-Kit Receptor (CD117) is a Feature of Almost All Subtypes of De Novo Acute Myeloblastic Leukemia (AML), Including Cytogenetically Good-Risk AML, and Lacks Prognostic Significance

1999 • 64 citations

Overexpression of the AML1 proto-oncoprotein in NIH3T3 cells leads to neoplastic transformation depending on the DNA-binding and transactivational potencies.

1996 • 62 citations

The t(8;21) fusion protein, AML1/ETO, transforms NIH3T3 cells and activates AP-1

1999 • 59 citations

Identification of a Common Ecotropic Viral Integration Site, Evi-1, in the DNA of AKXD Murine Myeloid Tumors

1988 • 51 citations

The chimeric genes AML1/MDS1 and AML1/EAP inhibit AML1B activation at the CSF1R promoter, but only AML1/MDS1 has tumor-promoter properties.

1996 • 50 citations

The AML1/Evi-1 fusion protein in the t(3;21) translocation exhibits transforming activity on Rat1 fibroblasts with dependence on the Evi-1 sequence.

1995 • 42 citations

CD117 (c-kit) is a restricted antigen of acute myeloid leukemia and characterizes early differentiative levels of M5 FAB subtype.

1998 • 39 citations

Enhanced myeloid specificity of CD 117 compared with CD13 and CD33

1999 • 31 citations

t(3;21)(q26;q22) with AML1 rearrangement in a de novo childhood acute monoblastic leukaemia

1996 • 16 citations