Active apical secretory efflux of the HIV protease inhibitors saquinavir and ritonavir in Caco-2 cell monolayers.

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P‐glycoprotein: Implications for drug delivery and activity in cancer chemotherapy

1995 • 856 citations

Epithelial Transport Of Drugs In Cell Culture. I: A Model For Studying The Passive Diffusion Of Drugs Over Intestinal Absorbtive (Caco-2) Cells

1990 • 820 citations

ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans.

1995 • 546 citations

P-glycoprotein—A mediator of multidrug resistance in tumour cells

1996 • 406 citations

Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulators

1993 • 365 citations

Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes.

1996 • 342 citations

The Effect of High-Dose Saquinavir on Viral Load and CD4+ T-Cell Counts in HIV-Infected Patients

1996 • 302 citations

Relevance of p‐glycoprotein for the enteral absorption of cyclosporin A: in vitro‐in vivo correlation

1996 • 221 citations

Drug absorption limited by P-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers.

1993 • 217 citations

Intestinal drug metabolism and antitransport processes: A potential paradigm shift in oral drug delivery

1996 • 194 citations

Saquinavir

1996 • 189 citations

Evidence for a Polarized Efflux System in Caco-2 Cells Capable of Modulating Cyclosporine A Transport

1993 • 167 citations

Restricted transport of cyclosporin A across the blood-brain barrier by a multidrug transporter, P-glycoprotein

1993 • 157 citations

CYP3A-like cytochrome P450-mediated metabolism and polarized efflux of cyclosporin A in Caco-2 cells.

1996 • 143 citations

Polarized transport of docetaxel and vinblastine mediated by P-glycoprotein in human intestinal epithelial cell monolayers

1994 • 134 citations

Current Knowledge and Future Prospects for the Use of HIV Protease Inhibitors

1996 • 129 citations

Age-dependent expression of P-glycoprotein gp170 in Caco-2 cell monolayers.

1996 • 119 citations

P-glycoprotein and pharmacokinetics.

1995 • 92 citations

Membrane interactions of some catamphiphilic drugs and relation to their multidrug-resistance-reversing ability

1996 • 69 citations

Apparent dose‐dependent oral absorption of cyclosporin a in rats

1984 • 49 citations

Structure-activity-relationship studies on modulators of the multidrug transporter P-glycoprotein--an overview.

1995 • 24 citations