Intestinal drug metabolism and antitransport processes: A potential paradigm shift in oral drug delivery

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P‐glycoprotein: Implications for drug delivery and activity in cancer chemotherapy

1995 • 856 citations

Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes.

1992 • 536 citations

Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man.

1987 • 475 citations

First-pass metabolism of cyclosporin by the gut

1991 • 425 citations

Differentiation of absorption and first-pass gut and hepatic metabolism in humans: Studies with cyclosporine*

1995 • 342 citations

Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction

1992 • 337 citations

The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine*

1995 • 275 citations

Individual Variation in First-Pass Metabolism

1993 • 74 citations

Factors Influencing Drug Absorption and Drug Availability

2002 • 31 citations

Clinical pharmacokinetics: Concepts and applications

1983 • 1 citations

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