Hereditary and Familial Colon Cancer

Environmental and Heritable Factors in the Causation of Cancer — Analyses of Cohorts of Twins from Sweden, Denmark, and Finland

2000 • 4,020 citations

de la Chapelle, A.

1997 • 3,184 citations

Colorectal cancer screening and surveillance: Clinical guidelines and rationale?Update based on new evidence

2003 • 2,185 citations

Hereditary Colorectal Cancer

2003 • 2,142 citations

Tumor Microsatellite-Instability Status as a Predictor of Benefit from Fluorouracil-Based Adjuvant Chemotherapy for Colon Cancer

2003 • 2,056 citations

Controlled 15-year trial on screening for colorectal cancer in families with hereditary nonpolyposis colorectal cancer

2000 • 1,304 citations

Feasibility of Screening for Lynch Syndrome Among Patients With Colorectal Cancer

2008 • 836 citations

Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3′ exons of TACSTD1

2008 • 757 citations

Prophylactic Surgery to Reduce the Risk of Gynecologic Cancers in the Lynch Syndrome

2006 • 751 citations

Genomewide Association Studies and Human Disease

2009 • 725 citations

A systematic review and meta-analysis of familial colorectal cancer risk

2001 • 699 citations

Screening for Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer) among Endometrial Cancer Patients

2006 • 612 citations

Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21

2008 • 606 citations

Lower Cancer Incidence in Amsterdam-I Criteria Families Without Mismatch Repair Deficiency

2005 • 537 citations

The Clinical Phenotype of Lynch Syndrome Due to Germ-Line PMS2 Mutations

2008 • 522 citations

A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk

2007 • 518 citations

The genetics of hereditary colon cancer

2007 • 515 citations

Risk of Pancreatic Cancer in Families With Lynch Syndrome

2009 • 498 citations

Mutations Associated with HNPCC Predisposition — Update of ICG-HNPCC/INSiGHT Mutation Database

2004 • 436 citations

Duodenal adenomatosis in familial adenomatous polyposis

2004 • 423 citations

New insights into the aetiology of colorectal cancer from genome-wide association studies

2009 • 382 citations

Serrated Polyps of the Large Intestine: A Morphologic and Molecular Review of an Evolving Concept

2005 • 364 citations

Correlations between mutation site in APC and phenotype of familial adenomatous polyposis (FAP): A review of the literature

2006 • 358 citations

Calculation of Risk of Colorectal and Endometrial Cancer Among Patients With Lynch Syndrome

2009 • 346 citations

The Hamartomatous Polyposis Syndromes: A Clinical and Molecular Review

2005 • 344 citations

Expanded Extracolonic Tumor Spectrum in MUTYH-Associated Polyposis

2009 • 329 citations

Colorectal Cancer Screening

2010 • 306 citations

Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk

2007 • 305 citations

Cowden Syndrome: A Critical Review of the Clinical Literature

2008 • 300 citations

Attenuated familial adenomatous polyposis (AFAP). A review of the literature.

2003 • 287 citations

Risk of colorectal cancer in juvenile polyposis

2007 • 257 citations

TGF-β signaling alterations and susceptibility to colorectal cancer

2007 • 244 citations

ASCO/SSO Review of Current Role of Risk-Reducing Surgery in Common Hereditary Cancer Syndromes

2006 • 242 citations

Lower Incidence of Colorectal Cancer and Later Age of Disease Onset in 27 Families With Pathogenic MSH6 Germline Mutations Compared With Families With MLH1 or MSH2 Mutations: The German Hereditary Nonpolyposis Colorectal Cancer Consortium

2004 • 238 citations

Increased colorectal cancer risk during follow-up in patients with hyperplastic polyposis syndrome: a multicentre cohort study

2009 • 231 citations

Polymorphisms and colorectal tumor risk

2001 • 231 citations

Germline MutY Human Homologue Mutations and Colorectal Cancer: A Multisite Case-Control Study

2008 • 222 citations

Clinical Implications of the Colorectal Cancer Risk Associated With MUTYH Mutation

2009 • 206 citations

Fundic Gland Polyp Dysplasia Is Common in Familial Adenomatous Polyposis

2008 • 201 citations

Genetic testing for high-risk colon cancer patients1 1Abbreviations used in this paper: FAP, familial adenomatous polyposis; HMPS, hereditary mixed polyposis syndrome; HNPCC, hereditary nonpolyposis colon cancer; JPS, juvenile polyposis; MMR, mutation mismatch repair; MSI, microsatellite instability; PJS, Peutz-Jeghers syndrome; TGF, transforming growth factor.

2003 • 199 citations

Hereditary ovarian carcinoma: Heterogeneity, molecular genetics, pathology, and management

2009 • 198 citations

Germline hypermethylation of MLH1 and EPCAM deletions are a frequent cause of Lynch syndrome

2009 • 195 citations

Genetic testing and phenotype in a large kindred with attenuated familial adenomatous polyposis

2004 • 193 citations

Narrow-Band Versus White-Light High Definition Television Endoscopic Imaging for Screening Colonoscopy: A Prospective Randomized Trial

2008 • 191 citations

Hyperplastic Polyps and Sessile Serrated Adenomas as a Phenotypic Expression of MYH-Associated Polyposis

2008 • 187 citations

Hyperplastic Polyposis Syndrome: Phenotypic Presentations and the Role of MBD4 and MYH

2006 • 185 citations

Deletions removing the last exon ofTACSTD1constitute a distinct class of mutations predisposing to Lynch syndrome

2009 • 164 citations

Hamartomatous polyposis syndromes

2009 • 158 citations

Somatic APC mosaicism: an underestimated cause of polyposis coli

2007 • 149 citations

Extensive DNA methylation in normal colorectal mucosa in hyperplastic polyposis

2006 • 146 citations

Defining the Criteria for Local Resection of Ampullary Neoplasms

1996 • 140 citations

Gastric fundic gland polyps

2003 • 137 citations

Peutz-Jeghers syndrome: clinicopathology and molecular alterations

2006 • 136 citations

Prevalence of Thyroid Cancer in Familial Adenomatous Polyposis Syndrome and the Role of Screening Ultrasound Examinations

2007 • 128 citations

Hereditary non-polyposis colorectal cancer: clinical and molecular evidence for a new entity of hereditary colorectal cancer

2005 • 120 citations

A subset of familial colorectal neoplasia kindreds linked to chromosome 9q22.2-31.2

2003 • 117 citations

Interaction of estrogen therapy with calcium and vitamin D supplementation on colorectal cancer risk: Reanalysis of Women's Health Initiative randomized trial

2007 • 113 citations

Variation in the Selenoenzyme Genes and Risk of Advanced Distal Colorectal Adenoma

2008 • 112 citations

The Case for a Genetic Predisposition to Serrated Neoplasia in the Colorectum: Hypothesis and Review of the Literature

2006 • 104 citations

Surveillance colonoscopy improves survival in a cohort of subjects with a single mismatch repair gene mutation

2008 • 96 citations

Cost‐effectiveness analysis of prevention strategies for gynecologic cancers in Lynch syndrome

2008 • 92 citations

Chromosome 8q23.3 and 11q23.1 Variants Modify Colorectal Cancer Risk in Lynch Syndrome

2008 • 91 citations

Exploring SNP‐SNP interactions and colon cancer risk using polymorphism interaction analysis

2005 • 89 citations

Meta Association of Colorectal Cancer Confirms Risk Alleles at 8q24 and 18q21

2009 • 84 citations

p53 Arg72Pro polymorphism and risk of colorectal adenoma and cancer

2006 • 83 citations

Surveillance and management of upper gastrointestinal disease in Familial Adenomatous Polyposis

2006 • 74 citations

Prospective evaluation of DNA mismatch repair protein expression in primary endometrial cancer

2009 • 70 citations

Variation in TCF7L2 and Increased Risk of Colon Cancer

2008 • 68 citations

Insulin-like Growth Factor Polymorphisms and Colorectal Cancer Risk

2005 • 68 citations

High Serum Selenium and Reduced Risk of Advanced Colorectal Adenoma in a Colorectal Cancer Early Detection Program

2006 • 67 citations

Frequency of Familial Colon Cancer and Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome) in a Large Population Database

2005 • 66 citations

Markedly enhanced colon tumorigenesis in Apc ^Min mice lacking glutathione S-transferase Pi

2009 • 65 citations

Vitamin D Related Genes,CYP24A1andCYP27B1,and Colon Cancer Risk

2009 • 62 citations

GSTM1 and GSTT1 Polymorphisms, Cigarette Smoking, and Risk of Colon Cancer: A Population-based Case-control Study in North Carolina (United States)

2006 • 60 citations

Desmoid tumours in patients with familial adenomatous polyposis and desmoid region adenomatous polyposis coli mutations

2007 • 59 citations

Tgfbr1Haploinsufficiency Is a Potent Modifier of Colorectal Cancer Development

2009 • 56 citations

Evidence for a colorectal cancer susceptibility locus on chromosome 3q21-q24 from a high-density SNP genome-wide linkage scan

2006 • 55 citations

Gastrointestinal Polyposes: Clinical, Pathological and Molecular Features

2007 • 49 citations

Hyperplastic polyposis in the New Zealand population: a condition associated with increased colorectal cancer risk and European ancestry.

2007 • 48 citations

Ornithine Decarboxylase Polymorphism Modification of Response to Aspirin Treatment for Colorectal Adenoma Prevention

2006 • 48 citations

Analysis of candidate modifier loci for the severity of colonic familial adenomatous polyposis, with evidence for the importance of the N-acetyl transferases

2004 • 47 citations

MLH1 −93G>A promoter polymorphism and risk of mismatch repair deficient colorectal cancer

2008 • 45 citations

A novel SNP in a vitamin D response element of the CYP24A1 promoter reduces protein binding, transactivation, and gene expression

2008 • 45 citations

Colorectal Cancer Risk Is Not Associated with Increased Levels of Homozygosity in a Population from the United Kingdom

2009 • 43 citations

Haemochromatosis HFE gene polymorphisms as potential modifiers of hereditary nonpolyposis colorectal cancer risk and onset age

2009 • 42 citations

Common Familial Colorectal Cancer Linked to Chromosome 7q31: A Genome-Wide Analysis

2008 • 41 citations

GSTM1 and GSTT1 polymorphisms as modifiers of age at diagnosis of hereditary nonpolyposis colorectal cancer (HNPCC) in a homogeneous cohort of individuals carrying a single predisposing mutation

2006 • 39 citations

Association of the TCF7L2 polymorphism with colorectal cancer and adenoma risk

2008 • 38 citations

A genome wide linkage analysis in Swedish families with hereditary non-familial adenomatous polyposis/non-hereditary non-polyposis colorectal cancer

2005 • 36 citations

Identification of Susceptibility Genes for Cancer in a Genome-wide Scan: Results from the Colon Neoplasia Sibling Study

2008 • 34 citations

Life After GWA Studies

2009 • 34 citations

APC Asp1822Val and Gly2502Ser Polymorphisms and Risk of Colorectal Cancer and Adenoma

2005 • 34 citations

Cyclin D1 A870G polymorphism and the risk of colorectal cancer and adenoma

2006 • 32 citations

IGF1 is a modifier of disease risk in hereditary non‐polyposis colorectal cancer

2008 • 24 citations

Do polymorphisms and haplotypes of mismatch repair genes modulate risk of sporadic colorectal cancer?

2008 • 21 citations

Colorectal Polyps in Carriers of the APC I1307K Polymorphism

2005 • 19 citations

The characterization of somatic APC mutations in colonic adenomas and carcinomas in Ashkenazi Jews with the APC I1307K variant using linkage disequilibrium

2002 • 18 citations

A Comprehensive Strategy to Combat Colon Cancer Targeting the Adenomatous Polyposis Coli Tumor Suppressor Gene

2005 • 15 citations

A genome-wide scan of 10 000 gene-centric variants and colorectal cancer risk

2009 • 11 citations

6000 Aspirin prevents cancer in Lynch syndrome

2009 • 8 citations

Prophylactic colectomy for hyperplastic polyposis

2009 • 5 citations