Insulin-like Growth Factor Polymorphisms and Colorectal Cancer Risk

Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women: Principal Results From the Women's Health Initiative Randomized Controlled Trial

2002 • 15,184 citations

Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions*

1995 • 4,419 citations

Compendium of Physical Activities: classification of energy costs of human physical activities

1993 • 4,024 citations

Relation of Body Fat Distribution to Metabolic Complications of Obesity*

1982 • 1,919 citations

Food, nutrition and the prevention of cancer : a global perspective

1997 • 1,892 citations

Cellular Actions of the Insulin-Like Growth Factor Binding Proteins

2002 • 1,717 citations

Prospective Study of Colorectal Cancer Risk in Men and Plasma Levels of Insulin-Like Growth Factor (IGF)-I and IGF-Binding Protein-3

1999 • 1,128 citations

Intrauterine Growth Retardation and Postnatal Growth Failure Associated with Deletion of the Insulin-Like Growth Factor I Gene

1996 • 1,094 citations

Metabolic Implications of Body Fat Distribution

1991 • 1,053 citations

Insulin, Insulin-Like Growth Factors and Colon Cancer: A Review of the Evidence

2001 • 941 citations

Increased cell division as a cause of human cancer.

1990 • 894 citations

Colorectal Cancer: Molecules and Populations

1999 • 894 citations

Insulin and colon cancer

1995 • 815 citations

Serum C-Peptide, Insulin-Like Growth Factor (IGF)-I, IGF-Binding Proteins, and Colorectal Cancer Risk in Women

2000 • 653 citations

Adipose tissue as a source of hormones

1987 • 597 citations

Postmenopausal hormone therapy and the risk of colorectal cancer: a review and meta-analysis

1999 • 577 citations

Contrasting Effects of Oral and Transdermal Routes of Estrogen Replacement Therapy on 24-Hour Growth Hormone (GH) Secretion, Insulin-Like Growth Factor I, and GH-Binding Protein in Postmenopausal Women*

1991 • 510 citations

Insulin-like growth factor binding proteins and their role in controlling IGF actions

1997 • 510 citations

Epidemiology of colorectal cancer revisited: are serum triglycerides and/or plasma glucose associated with risk?

1994 • 480 citations

A prospective study of plasma insulin-like growth factor-1 and binding protein-3 and risk of colorectal neoplasia in women.

2000 • 407 citations

Nutrition and colorectal cancer

1996 • 367 citations

A Polymorphism in the Gene for IGF-I

2001 • 353 citations

Association Between Serum Insulin Growth Factor-I (IGF-I) and a Simple Sequence Repeat in IGF-I Gene: Implications for Genetic Studies of Bone Mineral Density

1998 • 303 citations

Long-Term Efficacy of Sigmoidoscopy in the Reduction of Colorectal Cancer Incidence

2003 • 214 citations

Insulin-Like Growth Factor Binding Proteins: New Proteins, New Functions

1999 • 213 citations

Association between genetic variation in the gene for insulin-like growth factor-l and low birthweight

2002 • 211 citations

Novel Promoter Polymorphism in Insulin-Like Growth Factor-Binding Protein-3: Correlation with Serum Levels and Interaction with Known Regulators¹

2001 • 211 citations

Reversal of Relation Between Body Mass and Endogenous Estrogen Concentrations With Menopausal Status

1996 • 208 citations

Insulin-Like Growth Factor-1 Inhibition of Apoptosis Is Associated with Increased Expression of the bcl-xL Gene Product

1997 • 208 citations

IGF-I and IGF-II in relation to colorectal cancer

1999 • 190 citations

Milk Intake, Circulating Levels of Insulin-Like Growth Factor-I, and Risk of Colorectal Cancer in Men

2001 • 186 citations

A simple mouthwash method for obtaining genomic DNA in molecular epidemiological studies.

1998 • 186 citations

Genetic and nongenetic factors associated with variation of plasma levels of insulin-like growth factor-I and insulin-like growth factor-binding protein-3 in healthy premenopausal women.

2001 • 183 citations

Insulin and Insulin‐like Growth Factor 1 Stimulate Proliferation of Metastatic Variants of Colon Carcinoma 26

1989 • 181 citations

A prospective study of plasma levels of insulin-like growth factor I (IGF-I) and IGF-binding protein-3, and colorectal cancer risk among men

2000 • 181 citations

Characterization of insulinlike growth factor I receptors in human colon cancer

1992 • 174 citations

A Putative Functional Polymorphism in the IGF-I Gene

2002 • 148 citations

Physical activity and colon cancer: A public health perspective

1997 • 141 citations

Presence of somatomedin receptors on primary human breast and colon carcinomas

1987 • 141 citations

Novel Promoter Polymorphism in Insulin-Like Growth Factor-Binding Protein-3: Correlation with Serum Levels and Interaction with Known Regulators

2001 • 137 citations

Trinucleotide repeat polymorphism in the androgen receptor gene (AR)

1992 • 127 citations

IGF-1, IGF-2 and IGFBP-3 in prediagnostic serum: association with colorectal cancer in a cohort of Chinese men in Shanghai

2001 • 123 citations

Substitutions for Hydrophobic Amino Acids in the N-terminal Domains of IGFBP-3 and -5 Markedly Reduce IGF-I Binding and Alter Their Biologic Actions

2000 • 121 citations

Differential effects of oral conjugated estrogens and transdermal estradiol on insulin-like growth factor 1, growth hormone and sex hormone binding globulin serum levels

1993 • 116 citations

Growth-Regulatory Effects of Sensory Neuropeptides, Epidermal Growth Factor, Insulin, and Somatostatin on the Non-Transformed Intestinal Epithelial Cell Line IEC-6 and the Colon Cancer Cell Line HT 29

1993 • 115 citations

Associations among IRS1, IRS2, IGF1, and IGFBP3 Genetic Polymorphisms and Colorectal Cancer

2004 • 114 citations

Insulin-Like Growth Factor I Modulates Induction of Apoptotic Signaling in H9C2 Cardiac Muscle Cells¹

1998 • 113 citations

Alterations in serum levels of insulin‐like growth factors and insulin‐like growth‐factor‐binding proteins in patients with colorectal cancer

1994 • 108 citations

IL-4 and insulin-like growth factor-I inhibit the decline in Bcl-2 and promote the survival of IL-3-deprived myeloid progenitors.

1997 • 106 citations

Regulation of hepatic growth hormone receptors by insulin

1978 • 102 citations

Association and linkage between an insulin-like growth FACTOR-1 GENE polymorphism and fat free mass in the HERITAGE Family Study

1999 • 100 citations

A sequence repeat in the insulin‐like growth factor‐1 gene and risk of breast cancer

2002 • 98 citations

High-risk colorectal adenomas and serum insulin-like growth factors

2001 • 89 citations

Insulin-like growth factor-I induces cyclin-D1 expression in MG63 human osteosarcoma cells in vitro.

1994 • 79 citations

Association of a Common Polymorphism in the Human GH1 Gene with Colorectal Neoplasia

2002 • 77 citations

Polymorphic variation at the ‐202 locus in IGFBP3: Influence on serum levels of insulin‐like growth factors, interaction with plasma retinol and vitamin D and breast cancer risk

2003 • 76 citations

IGFBP-3 mediates TGF-β1-induced cell growth in human airway smooth muscle cells

2000 • 76 citations

Polymorphic CA repeats in the IGF-I gene and breast cancer

2001 • 70 citations

Mutation of Three Critical Amino Acids of the N-Terminal Domain of IGF-Binding Protein-3 Essential for High Affinity IGF Binding

2001 • 67 citations

Sibling Pair Linkage and Association Studies between Bone Mineral Density and the Insulin-Like Growth Factor I Gene Locus1

1999 • 62 citations

Polymorphism of Insulin-like Growth Factor I Gene and Bone Mineral Density

1998 • 61 citations

The relationship among serum insulin-like growth factor-I, insulin-like growth factor-I gene polymorphism, and bone mineral density in postmenopausal women in Korea

2002 • 59 citations

Progestins abrogate estrogen-induced changes in the insulin-like growth factor axis

2000 • 58 citations

Serum insulin-like growth factor I (IGF-I) concentration in men is not associated with the cytosine-adenosine repeat polymorphism of the IGF-I gene.

2002 • 58 citations

Studies of the Variability of the Genes Encoding the Insulin-Like Growth Factor I Receptor and Its Ligand in Relation to Type 2 Diabetes Mellitus1

2000 • 57 citations

Selection Bias in the Assessment of Gene-Environment Interaction in Case-Control Studies

2003 • 56 citations

Serum Insulin-like Growth Factor I and Subsequent Risk of Colorectal Cancer among Japanese-American Men

2003 • 54 citations

The insulin-like growth factor-I system and hormone replacement therapy

2001 • 53 citations

Insulin and IGF Binding by IGFBP-3 Fragments Derived From Proteolysis, Baculovirus Expression and Normal Human Urine

1998 • 52 citations

Effect of menopause and different combined estradiol-progestin regimens on basal and growth hormone-releasing hormone–stimulated serum growth hormone, insulin-like growth factor-1, insulin-like growth factor binding protein (IGFBP)-1, and IGFBP-3 levels

1999 • 47 citations

Effect of Sex Hormone Replacement on the Insulin-Like Growth Factor System and Bone Mineral: A Cross-Sectional and Longitudinal Study in 595 Perimenopausal Women Participating in the Danish Osteoporosis Prevention Study¹

1999 • 47 citations

Igfbp-3 mediates TGFβ1 proliferative response in colon cancer cells

2000 • 46 citations

Mspl polymorphism of the human CYP2E gene

1991 • 31 citations

Effect of Sex Hormone Replacement on the Insulin-Like Growth Factor System and Bone Mineral: A Cross-Sectional and Longitudinal Study in 595 Perimenopausal Women Participating in the Danish Osteoporosis Prevention Study

1999 • 30 citations

Sibling Pair Linkage and Association Studies between Bone Mineral Density and the Insulin-Like Growth Factor I Gene Locus

1999 • 29 citations

Insulin-like growth factor I polymorphism and breast cancer risk in Jewish women.

2002 • 27 citations

Studies of the Variability of the Genes Encoding the Insulin-Like Growth Factor I Receptor and Its Ligand in Relation to Type 2 Diabetes Mellitus

2000 • 25 citations

Dinucleotide repeat in the insulin-like growth factor-I gene is not related to risk of colorectal adenoma.

2002 • 21 citations

Sequence alterations of insulin-like growth factor binding protein 3 in neoplastic and normal gastrointestinal tissues.

1998 • 17 citations

Dinucleotide repeat polymorphism at the human gene for insulin-like growth afctor I (IGFI)

1991 • 13 citations

A common polymorphism in the human insulin-like growth factor binding protein 3 gene

2000 • 11 citations

Trinucleotide repeat polymorphism at the human insulin-like growth factor I receptor gene (IGF1R)

1992 • 11 citations

A polymorphism in the gene for insulin-like growth factor-I: Functional properties and risk for type 2 diabetes mellitus and myocardial infarction

2000 • 10 citations