The Case for a Genetic Predisposition to Serrated Neoplasia in the Colorectum: Hypothesis and Review of the Literature

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

Lessons from Hereditary Colorectal Cancer

1996 • 4,900 citations

Report of two cases

2005 • 2,810 citations

CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer

2006 • 1,883 citations

Inherited variants of MYH associated with somatic G:C→T:A mutations in colorectal tumors

2002 • 1,346 citations

Pathology and Genetics of Tumours of the Digestive System

2001 • 1,210 citations

A genetic explanation of Slaughter's concept of field cancerization: evidence and clinical implications.

2003 • 1,174 citations

Guidelines for Colonoscopy Surveillance After Polypectomy: A Consensus Update by the US Multi-Society Task Force on Colorectal Cancer and the American Cancer Society

2006 • 742 citations

Poor Survival Associated with the BRAF V600E Mutation in Microsatellite-Stable Colon Cancers

2005 • 725 citations

BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum

2004 • 716 citations

Mixed Hyperplastic Adenomatous Polyps/Serrated Adenomas

1990 • 667 citations

Aging and DNA methylation in colorectal mucosa and cancer.

1998 • 620 citations

Morphologic Reappraisal of Serrated Colorectal Polyps

2003 • 604 citations

Evaluation of a Large, Population-Based Sample Supports a CpG Island Methylator Phenotype in Colon Cancer

2005 • 571 citations

Lower Cancer Incidence in Amsterdam-I Criteria Families Without Mismatch Repair Deficiency

2005 • 537 citations

Emerging concepts in colorectal neoplasia

2002 • 495 citations

MGMT Promoter Methylation and Field Defect in Sporadic Colorectal Cancer

2005 • 485 citations

Germline epimutation of MLH1 in individuals with multiple cancers

2004 • 470 citations

Evidence for an instructive mechanism of de novo methylation in cancer cells

2006 • 465 citations

Morphology of sporadic colorectal cancer with DNA replication errors

1998 • 465 citations

Biallelic germline mutations in MYH predispose to multiple colorectal adenoma and somatic G:C->T:A mutations

2002 • 410 citations

BRAF Mutation Is Frequently Present in Sporadic Colorectal Cancer with Methylated hMLH1, But Not in Hereditary Nonpolyposis Colorectal Cancer

2004 • 404 citations

Cancer epigenetics

2005 • 393 citations

Prognostic value of proliferation in invasive breast cancer: a review

2004 • 370 citations

Serrated Polyps of the Large Intestine: A Morphologic and Molecular Review of an Evolving Concept

2005 • 364 citations

Serrated adenomatous polyposis in humans

1996 • 360 citations

CpG island methylator phenotype (CIMP) of colorectal cancer is best characterised by quantitative DNA methylation analysis and prospective cohort studies

2006 • 358 citations

Associations Between Cigarette Smoking, Lifestyle Factors, and Microsatellite Instability in Colon Tumors

2000 • 336 citations

BRAF and KRAS mutations in colorectal hyperplastic polyps and serrated adenomas.

2003 • 329 citations

Neoplastic progression occurs through mutator pathways in hyperplastic polyposis of the colorectum

2000 • 255 citations

Hyperplastic-like Colon Polyps That Preceded Microsatellite-Unstable Adenocarcinomas

2003 • 253 citations

Colorectal carcinoma associated with serrated adenoma - prevalence, histological features, and prognosis

2001 • 244 citations

Frequent CpG Island Methylation in Serrated Adenomas of the Colorectum

2003 • 238 citations

Hyperplastic-like Colon Polyps That Preceded Microsatellite-Unstable Adenocarcinomas

2003 • 234 citations

Polymorphisms and colorectal tumor risk

2001 • 231 citations

Demographic and pathological characteristics of serrated polyps of colorectum

2005 • 231 citations

Phenotypic and molecular characteristics of hyperplastic polyposis

2000 • 217 citations

Promoter Hypermethylation Frequency and BRAF Mutations Distinguish Hereditary Non-Polyposis Colon Cancer from Sporadic MSI-H Colon Cancer

2002 • 201 citations

Serrated adenoma of the colorectum and the DNA-methylator phenotype

2005 • 191 citations

Hyperplastic Polyposis Syndrome: Phenotypic Presentations and the Role of MBD4 and MYH

2006 • 185 citations

Hyperplastic Polyposis

2001 • 182 citations

Concordant CpG Island Methylation in Hyperplastic Polyposis

2002 • 182 citations

Metaplastic polyps and polyposis of the colorectum

1980 • 171 citations

Computational prediction of methylation status in human genomic sequences

2006 • 171 citations

Hyperplastic (Serrated) Polyps of the Colorectum

2004 • 168 citations

FAMILIAL GIANT HYPERPLASTIC POLYPOSIS PREDISPOSING TO COLORECTAL CANCER: A NEW HEREDITARY BOWEL CANCER SYNDROME

1996 • 164 citations

Methylation patterns define two types of hyperplastic polyp associated with colorectal cancer

2004 • 152 citations

Hyperplastic polyps and DNA microsatellite unstable cancers of the colorectum

2000 • 151 citations

Dominant genes for colorectal cancer are not rare

1992 • 150 citations

Hyperplastic Polyposis and the Risk of Colorectal Cancer

2004 • 149 citations

Small colonic microsatellite unstable adenocarcinomas and high-grade epithelial dysplasias in sessile serrated adenoma polypectomy specimens: a study of eight cases.

2006 • 149 citations

Extensive DNA methylation in normal colorectal mucosa in hyperplastic polyposis

2006 • 146 citations

Small Colonic Microsatellite Unstable Adenocarcinomas and High-Grade Epithelial Dysplasias in Sessile Serrated Adenoma Polypectomy Specimens

2006 • 134 citations

DNA hypermethylation in the normal colonic mucosa of patients with colorectal cancer

2006 • 129 citations

Morphological and molecular heterogeneity within nonmicrosatellite instability-high colorectal cancer.

2002 • 128 citations

Evidence for BRAF mutation and variable levels of microsatellite instability in a syndrome of familial colorectal cancer

2005 • 124 citations

Hereditary non-polyposis colorectal cancer: clinical and molecular evidence for a new entity of hereditary colorectal cancer

2005 • 120 citations

HPP1 : A transmembrane protein-encoding gene commonly methylated in colorectal polyps and cancers

2000 • 120 citations

BRAF Mutations in Aberrant Crypt Foci and Hyperplastic Polyposis

2005 • 118 citations

My approach to serrated polyps of the colorectum

2004 • 117 citations

Serrated Pathway and APC (Conventional)-Type Colorectal Polyps

2006 • 115 citations

Differential Features of Colorectal Cancers Fulfilling Amsterdam Criteria without Involvement of the Mutator Pathway

2005 • 115 citations

DNA motifs associated with aberrant CpG island methylation

2006 • 111 citations

Hyperplastic Polyposis Coli Syndrome and Colorectal Carcinoma

2006 • 107 citations

Association of the CpG island methylator phenotype with family history of cancer in patients with colorectal cancer.

2003 • 105 citations

Phenotypic Characteristics and Risk of Cancer Development in Hyperplastic Polyposis: Case Series and Literature Review

2004 • 103 citations

Epigenetic events in the colorectum and in colon cancer

2005 • 97 citations

Hyperplastic Polyposis of the Colorectum and Adenocarcinoma in a 24-Year-Old Man

1987 • 94 citations

Management of Portuguese Patients with Hyperplastic Polyposis and Screening of At-Risk First-Degree Relatives: A Contribution for Future Guidelines Based on a Clinical Study

2004 • 87 citations

Mixed epithelial polyps in association with hereditary non-polyposis colorectal cancer providing an alternative pathway of cancer histogenesis

1997 • 87 citations

Hyperplastic polyps of the colorectum—Innocent or guilty?

2001 • 86 citations

Giant hyperplastic polyposis of the colon

1981 • 57 citations

Hyperplastic-adenomatous polyposis syndrome

1999 • 45 citations

5,10-Methylenetetrahydrofolate Reductase 677 and 1298 Polymorphisms, Folate Intake, and Microsatellite Instability in Colon Cancer

2005 • 42 citations

Serrated mucosal lesions of the colorectum

2005 • 42 citations

Hyperplastic polyposis of the colon and rectum

2002 • 42 citations

DNA Repair Polymorphisms and Risk of Colorectal Adenomatous or Hyperplastic Polyps

2005 • 41 citations

Serrated Colorectal Polyps: Emerging Evidence Suggests the Need for a Reappraisal

2004 • 32 citations

Colorectal polyps and other precursor lesions

2002 • 32 citations

A Case of Hyperplastic Polyposis of the Colon with Adenocarcinomas in Hyperplastic Polyps after Long-Term Follow-Up

2002 • 31 citations

Hyperplastic (Metaplastic) Polyposis of the Colorectum Associated with Adenomas and an Adenocarcinoma

1997 • 31 citations

The CpG Island Methylator Phenotype Is Not Associated with a Personal or Family History of Cancer

2004 • 30 citations

Rectal Cancer in an 11-Year-Old Girl With Hyperplastic Polyposis

1999 • 28 citations

Familial risks for colorectal cancer show evidence on recessive inheritance

2005 • 26 citations

Clinical Significance of (Sessile) Serrated Adenomas

2005 • 24 citations

Serrated adenoma of the colorectum

2002 • 24 citations

Disappearance of hyperplastic polyposis after resection of rectal cancer

1991 • 20 citations

Hyperplastic polyposis asociated with synchronous adenocarcinomas of the transverse colon

2001 • 15 citations

Small Colonic Microsatellite Unstable Adenocarcinomas and High-Grade Epithelial Dysplasias in Sessile Serrated Adenoma Polypectomy Specimens

2005 • 14 citations

Comparative molecular pathology of sporadic hyperplastic polyps and neoplastic lesions from the same individual

2004 • 13 citations

Microsatellite instability of each tumor in sporadic synchronous multiple colorectal cancers

2001 • 12 citations

Hyperplastic polyposis coli associated with dysplasia

2001 • 5 citations

Hyperplastic polyps and serrated adenomas: Colonoscopic surveillance?

2004 • 4 citations

Deleted Work

1955 • 0 citations