Dynamics of colorectal cancer
Data up to Jan 2025
Total Citations Per Year
Abstract
References (64)
A genetic model for colorectal tumorigenesis
1990 • 11,800 citations
Mutation and Cancer: Statistical Study of Retinoblastoma
1971 • 7,335 citations
Genetic instabilities in human cancers
1998 • 4,165 citations
Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC
1997 • 3,847 citations
Genetic instability in colorectal cancers
1997 • 1,989 citations
APC mutations occur early during colorectal tumorigenesis
1992 • 1,901 citations
Multiple Intestinal Neoplasia Caused by a Mutation in the Murine Homolog of the APC Gene
1992 • 1,510 citations
Mutations of mitotic checkpoint genes in human cancers
1998 • 1,482 citations
A mathematic model for relating the drug sensitivity of tumors to their spontaneous mutation rate.
1979 • 1,331 citations
The age distribution of cancer and a multi-stage theory of carcinogenesis
2004 • 1,306 citations
Association of the APC Tumor Suppressor Protein with Catenins
1993 • 1,202 citations
Mutation and Cancer: A Model for Human Carcinogenesis2
1981 • 1,102 citations
Continuous and Discrete Mathematical Models of Tumor-induced Angiogenesis
1998 • 1,082 citations
Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer.
1998 • 998 citations
DNA Replication Fidelity
2000 • 980 citations
Identification of a Gene Located at Chromosome 5q21 that Is Mutated in Colorectal Cancers
1991 • 758 citations
A New Theory on the Cancer-inducing Mechanism
1953 • 744 citations
Identification of ras Oncogene Mutations in the Stool of Patients with Curable Colorectal Tumors
1992 • 703 citations
A Mutator Phenotype in Cancer 1
2001 • 675 citations
Connecting Chromosomes, Crisis, and Cancer
2002 • 564 citations
A Two-stage Theory of Carcinogenesis in Relation to the Age Distribution of Human Cancer
1957 • 553 citations
The role of chromosomal instability in tumor initiation
2002 • 543 citations
Errors in DNA replication as a basis of malignant changes.
1974 • 527 citations
The significance of unstable chromosomes in colorectal cancer
2003 • 500 citations
Dynamics of cancer progression
2004 • 486 citations
Chromosome segregation and cancer: cutting through the mystery
2001 • 459 citations
Multistage carcinogenesis and the incidence of colorectal cancer
2002 • 363 citations
Investigating stem cells in human colon by using methylation patterns
2001 • 356 citations
Detection ofAPCMutations in Fecal DNA from Patients with Colorectal Tumors
2002 • 333 citations
Genomic instability — the engine of tumorigenesis?
2003 • 330 citations
APC mutations in colorectal tumors with mismatch repair deficiency.
1996 • 329 citations
An evolutionary model of carcinogenesis.
2003 • 326 citations
Stem cells: the intestinal stem cell as a paradigm
2000 • 314 citations
The role of compensatory neutral mutations in molecular evolution
1985 • 282 citations
Stochastic Tunnels in Evolutionary Dynamics
2004 • 270 citations
Lineage selection and the evolution of multistage carcinogenesis
1999 • 212 citations
Mutation–selection networks of cancer initiation: tumor suppressor genes and chromosomal instability
2003 • 205 citations
Quantitative model for multiple levels of drug resistance in clinical tumors.
1983 • 191 citations
Can chromosomal instability initiate tumorigenesis?
2004 • 184 citations
A mathematical model to study the effects of drug resistance and vasculature on the response of solid tumors to chemotherapy
2000 • 180 citations
Genomic instability, DNA methylation, and natural selection in colorectal carcinogenesis
1999 • 163 citations
Multiple-Mutation Theory of Carcinogenesis
1958 • 162 citations
In vivo human somatic mutation: frequency and spectrum with age
1992 • 152 citations
How Many Mutations in a Cancer?
2002 • 129 citations
A mathematical model of the contribution of endothelial progenitor cells to angiogenesis in tumors: implications for antiangiogenic therapy
2003 • 118 citations
A mathematical model for the capillary endothelial cell-extracellular matrix interactions in wound-healing angiogenesis
1997 • 111 citations
A mathematical model of drug resistance: Heterogeneous tumors
1998 • 102 citations
A stochastic carcinogenesis model incorporating genomic instability fitted to colon cancer data
2003 • 101 citations
Linear Model of Colon Cancer Initiation
2004 • 94 citations
Age-specific incidence of inherited versus sporadic cancers: A test of the multistage theory of carcinogenesis
2005 • 81 citations
Dynamics of Genetic Instability in Sporadic and Familial Colorectal Cancer
2002 • 79 citations
Mathematical models of gene amplification with applications to cellular drug resistance and tumorigenicity.
1990 • 72 citations
Patterns of Cell Division and the Risk of Cancer
2003 • 65 citations
Population risk and physiological rate parameters for colon cancer. The union of an explicit model for carcinogenesis with the public health records of the United States
2000 • 59 citations
A mathematical analysis of a model for tumour angiogenesis
1995 • 58 citations
Generation Time of Epithelial Cells in the Human Colon
1962 • 57 citations
Stochastic elimination of cancer cells
2003 • 55 citations
Hypermutability in Carcinogenesis
1998 • 50 citations
A Mathematical Model for the Role of Cell Signal Transduction in the Initiation and Inhibition of Angiogenesis
2003 • 38 citations
Local Regulation of Homeostasis Favors Chromosomal Instability
2003 • 35 citations
A mathematical computer simulation model for the development of colonic polyps and colon cancer
1991 • 22 citations
Somatic Mutation: Early Cancer Steps Depend on Tissue Architecture
2003 • 22 citations
A Multi-stage Model of Adenoma Development
2000 • 13 citations
A proportional regression model for 20 year survival of colon cancer in Norway
1995 • 13 citations