Mutation–selection networks of cancer initiation: tumor suppressor genes and chromosomal instability

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

Genetic instabilities in human cancers

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Genetic instability in colorectal cancers

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Mutations of Chromosome 5q21 Genes in FAP and Colorectal Cancer Patients

1991 • 1,890 citations

Mutations of mitotic checkpoint genes in human cancers

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The Age Distribution of Cancer and a Multi-stage Theory of Carcinogenesis

1954 • 1,475 citations

A mathematic model for relating the drug sensitivity of tumors to their spontaneous mutation rate.

1979 • 1,331 citations

The age distribution of cancer and a multi-stage theory of carcinogenesis

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Two genetic hits (more or less) to cancer

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Mutation and Cancer: A Model for Human Carcinogenesis2

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Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene

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A New Theory on the Cancer-inducing Mechanism

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Generation of oscillations by the p53-Mdm2 feedback loop: A theoretical and experimental study

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A Two-stage Theory of Carcinogenesis in Relation to the Age Distribution of Human Cancer

1957 • 553 citations

Kinetochore Localization of Murine Bub1 Is Required for Normal Mitotic Timing and Checkpoint Response to Spindle Damage

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Growth of nonnecrotic tumors in the presence and absence of inhibitors

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Evidence that genetic instability occurs at an early stage of colorectal tumorigenesis.

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Cell Proliferation Kinetics in the Gastrointestinal Tract of Man

1963 • 382 citations

Multistage carcinogenesis and the incidence of colorectal cancer

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Investigating stem cells in human colon by using methylation patterns

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Stem cells: the intestinal stem cell as a paradigm

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A mathematical model for the age distribution of cancer in man

1969 • 282 citations

Cancer Cells Exhibit a Mutator Phenotype

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Mathematical models in cancer research

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Growth of necrotic tumors in the presence and absence of inhibitors

1996 • 227 citations

Cancer of the microsatellite mutator phenotype.

1996 • 226 citations

Measurement of in vivo proliferation in human colorectal mucosa using bromodeoxyuridine.

1992 • 218 citations

CELL PROLIFERATION KINETICS IN THE GASTROINTESTINAL TRACT OF MAN. I. CELL RENEWAL IN COLON AND RECTUM*

1963 • 185 citations

APC mutations are sufficient for the growth of early colorectal adenomas

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Carcinogen-specific induction of genetic instability

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Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement

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Multiple-Mutation Theory of Carcinogenesis

1958 • 162 citations

Cell kinetics in the jejunum and rectum of man

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Mutation and Cancer

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The mathematical modelling of tumour angiogenesis and invasion

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MATHEMATICAL MODELLING OF MACROPHAGE DYNAMICS IN TUMOURS

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Genetic instability in the development of drug resistance.

1985 • 70 citations

Population Genetics, Molecular Evolution, and the Neutral Theory: Selected Papers

1995 • 69 citations

Population risk and physiological rate parameters for colon cancer. The union of an explicit model for carcinogenesis with the public health records of the United States

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Genomic instability: first step to carcinogenesis.

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Models of Carcinogenesis as an Escape from Mitotic Inhibitors

1976 • 51 citations

Hypermutability in Carcinogenesis

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Population genetics, molecular evolution, and the neutral theory : selected papers

1994 • 48 citations

DNA repair defects inactivate tumor suppressor genes and induce hereditary and sporadic colon cancers.

2000 • 45 citations

Cytogenetic comparisons of synchronous carcinomas and polyps in patients with colorectal cancer

1997 • 40 citations

The Different Effects of Apoptosis and DNA Repair on Tumorigenesis

2002 • 27 citations

Allelic imbalance and cytogenetic deletion of 1p in colorectal adenomas: A target region identified between DIS199 and DIS234

1998 • 27 citations

Genetic instability and the evolution of angiogenic tumor cell lines (Review)

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A stochastic model of natural human fertility- algorithms and numerical examples

1977 • 7 citations