Stochastic Tunnels in Evolutionary Dynamics

Table of Integrals, Series, and Products

1980 • 19,996 citations

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Mutation and Cancer: Statistical Study of Retinoblastoma

1971 • 7,335 citations

Table of Integrals, Series, and Products

2000 • 7,068 citations

Genetic instabilities in human cancers

1998 • 4,165 citations

The Age Distribution of Cancer and a Multi-stage Theory of Carcinogenesis

1954 • 1,475 citations

A mathematic model for relating the drug sensitivity of tumors to their spontaneous mutation rate.

1979 • 1,331 citations

The age distribution of cancer and a multi-stage theory of carcinogenesis

2004 • 1,306 citations

The Genetic Basis of Human Cancer

1997 • 1,113 citations

Two genetic hits (more or less) to cancer

2001 • 1,108 citations

Mutation and Cancer: A Model for Human Carcinogenesis2

1981 • 1,102 citations

The Genetic Basis of Human Cancer

1999 • 827 citations

A New Theory on the Cancer-inducing Mechanism

1953 • 744 citations

Generation of oscillations by the p53-Mdm2 feedback loop: A theoretical and experimental study

2000 • 584 citations

A Two-stage Theory of Carcinogenesis in Relation to the Age Distribution of Human Cancer

1957 • 553 citations

The role of chromosomal instability in tumor initiation

2002 • 543 citations

Errors in DNA replication as a basis of malignant changes.

1974 • 527 citations

The significance of unstable chromosomes in colorectal cancer

2003 • 500 citations

Growth of nonnecrotic tumors in the presence and absence of inhibitors

1995 • 466 citations

Probability Models for DNA Sequence Evolution

2002 • 402 citations

Multistage carcinogenesis and the incidence of colorectal cancer

2002 • 363 citations

Stem cells: the intestinal stem cell as a paradigm

2000 • 314 citations

The role of compensatory neutral mutations in molecular evolution

1985 • 282 citations

A mathematical model for the age distribution of cancer in man

1969 • 282 citations

The Mutation Rate and Cancer

1998 • 258 citations

Cancer Cells Exhibit a Mutator Phenotype

1997 • 243 citations

Mathematical models in cancer research

1988 • 242 citations

Somatic stem cells and the kinetics of mutagenesis and carcinogenesis

2002 • 235 citations

Mathematical oncology: Cancer summed up

2003 • 235 citations

Growth of necrotic tumors in the presence and absence of inhibitors

1996 • 227 citations

Mutation–selection networks of cancer initiation: tumor suppressor genes and chromosomal instability

2003 • 205 citations

RNA Sequence Evolution With Secondary Structure Constraints: Comparison of Substitution Rate Models Using Maximum-Likelihood Methods

2001 • 186 citations

Multiple-Mutation Theory of Carcinogenesis

1958 • 162 citations

Radiation damage to the genetic material.

1950 • 141 citations

The Rate of Compensatory Evolution

1996 • 136 citations

Evolutionary dynamics of invasion and escape

2003 • 134 citations

Evolutionary dynamics of escape from biomedical intervention

2003 • 105 citations

A stochastic carcinogenesis model incorporating genomic instability fitted to colon cancer data

2003 • 101 citations

Probability Models For Dna Sequence Evolution

2004 • 96 citations

Analysis of chromosomal instability in human colorectal adenomas with two mutational hits at APC

2002 • 95 citations

Clonal basis of mammalian differentiation.

1971 • 90 citations

The mathematical modelling of tumour angiogenesis and invasion

1995 • 86 citations

Dynamics of Genetic Instability in Sporadic and Familial Colorectal Cancer

2002 • 79 citations

Waiting for a compensatory mutation: phase zero of the shifting-balance process

1996 • 77 citations

MATHEMATICAL MODELLING OF MACROPHAGE DYNAMICS IN TUMOURS

1999 • 75 citations

Compensatory neutral mutations and the evolution of RNA.

1998 • 72 citations

Selection Intensity Against Deleterious Mutations in RNA Secondary Structures and Rate of Compensatory Nucleotide Substitutions

2001 • 71 citations

Genetic instability in the development of drug resistance.

1985 • 70 citations

Patterns of Cell Division and the Risk of Cancer

2003 • 65 citations

Population risk and physiological rate parameters for colon cancer. The union of an explicit model for carcinogenesis with the public health records of the United States

2000 • 59 citations

Stochastic elimination of cancer cells

2003 • 55 citations

Untitled

1998 • 53 citations

Models of Carcinogenesis as an Escape from Mitotic Inhibitors

1976 • 51 citations

AN ESTIMATION OF PROLIFERATIVE POPULATION SIZE IN STOMACH, JEJUNUM AND COLON OF DBA‐2 MICE

1973 • 49 citations

Interaction of selection and recombination in the fixation of negative-epistatic genes

1996 • 48 citations

Local Regulation of Homeostasis Favors Chromosomal Instability

2003 • 35 citations

The Different Effects of Apoptosis and DNA Repair on Tumorigenesis

2002 • 27 citations

Genetic instability and the evolution of angiogenic tumor cell lines (Review)

2001 • 15 citations

Average time until fixation of mutants with compensatory fitness interaction.

1996 • 14 citations

A stochastic model of natural human fertility- algorithms and numerical examples

1977 • 7 citations

The Unstable Path To Cancer

2002 • 6 citations