Heparin induces dimerization and confers proliferative activity onto the hepatocyte growth factor antagonists NK1 and NK2.

Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor

1991 • 2,437 citations

Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product

1991 • 2,230 citations

Requirement of Heparan Sulfate for bFGF-Mediated Fibroblast Growth and Myoblast Differentiation

1991 • 1,507 citations

Proteoglycans as modulators of growth factor activities

1991 • 1,338 citations

Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor

1991 • 1,176 citations

Glycosaminoglycans: molecular properties, protein interactions, and role in physiological processes

1991 • 1,088 citations

Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development.

1993 • 707 citations

Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET.

1991 • 698 citations

Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cells.

1990 • 695 citations

Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor.

1991 • 663 citations

Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells.

1992 • 634 citations

A dual receptor system is required for basic fibroblast growth factor activity

1991 • 589 citations

Expression of the Met/HGF receptor in normal and neoplastic human tissues.

1991 • 481 citations

Hepatocyte growth factor receptor and the c-met oncogene Bottaro DP, Rubin JS, Faletto DL, Chan AM-L, Kmiecik TE, Vande Woude GF, Aaronson SA. Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science 1991;251:802?804

1991 • 434 citations

The Met receptor tyrosine kinase transduces motility, proliferation, and morphogenic signals of scatter factor/hepatocyte growth factor in epithelial cells.

1993 • 409 citations

Hepatocyte growth factor: molecular structure, roles in liver regeneration, and other biological functions.

1992 • 327 citations

Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor.

1992 • 316 citations

Structure and function of hepatocyte growth factor

1991 • 307 citations

Immunoreactive hepatocyte growth factor is a strong and independent predictor of recurrence and survival in human breast cancer.

1994 • 301 citations

Scatter factor and the c-met receptor: a paradigm for mesenchymal/epithelial interaction.

1994 • 279 citations

Heparin increases the affinity of basic fibroblast growth factor for its receptor but is not required for binding.

1994 • 262 citations

Hepatocyte growth factor--scatter factor: mitogen, motogen, and met.

1991 • 234 citations

Identification of a Competitive HGF Antagonist Encoded by an Alternative Transcript

1991 • 224 citations

A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis.

1992 • 222 citations

Biosynthesis of the protein encoded by the c-met proto-oncogene.

1989 • 220 citations

Expression of the c-Met/HGF receptor in human melanocytic neoplasms: demonstration of the relationship to malignant melanoma tumour progression

1993 • 206 citations

Identity of a tumor cytotoxic factor from human fibroblasts and hepatocyte growth factor

1990 • 195 citations

Coexpression of the c-met proto-oncogene and hepatocyte growth factor in human pancreatic cancer.

1994 • 187 citations

Sulfated Oligosaccharides Promote Hepatocyte Growth Factor Association and Govern Its Mitogenic Activity

1995 • 170 citations

Heparin Is Required for Cell-Free Binding of Basic Fibroblast Growth Factor to a Soluble Receptor and for Mitogenesis in Whole Cells

1992 • 160 citations

Met expression and sarcoma tumorigenicity.

1993 • 144 citations

The hormonal control of gluconeogenesis by regulation of mitochondrial pyruvate carboxylation in isolated rat liver cells.

1975 • 131 citations

Heparin-dependent binding and autophosphorylation of epidermal growth factor (EGF) receptor by heparin-binding EGF-like growth factor but not by EGF.

1994 • 122 citations

An alternatively processed mRNA generated from human hepatocyte growth factor gene

1991 • 111 citations

Hairpin loop and second kringle domain are essential sites for heparin binding and biological activity of hepatocyte growth factor.

1994 • 107 citations

Aberrant expression of c‐met mRNA in human gastric carcinomas

1993 • 107 citations

Effect of scatter factor on motility of epithelial cells and fibroblasts

1989 • 102 citations

Generation and characterization of a competitive antagonist of human hepatocyte growth factor, HGF/NK1

1993 • 92 citations

Tumorigenicity of the met Proto-Oncogene and the Gene for Hepatocyte Growth Factor

1992 • 83 citations

Immunohistochemical Detection of Hepatocyte Growth Factor/Scatter Factor in Human Cancerous and Inflammatory Lesions of Various Organs

1993 • 71 citations

Overexpression of the C-MET/HGF receptor in human thyroid carcinomas derived from the follicular epithelium

1995 • 63 citations

Hepatocyte growth factor specifically binds to sulfoglycolipids

1994 • 55 citations

Met proto-oncogene product is overexpressed in tumors of p53-deficient mice and tumors of Li-Fraumeni patients.

1995 • 54 citations

Identification of Mouse Mammary Fibroblast-Derived Mammary Growth Factor as Hepatocyte Growth-Factor

1994 • 34 citations