Impairment of Liver GH Receptor Signaling by Fasting

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

A family of cytokine-inducible inhibitors of signalling

1997 • 2,055 citations

Nutritional Regulation of the Insulin-Like Growth Factors*

1994 • 1,537 citations

Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance

1998 • 1,000 citations

Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression

1997 • 989 citations

Evidence for an Endogenous Ultradian Rhythm Governing Growth Hormone Secretion in the Rat

1976 • 743 citations

SOCS-3 Is an Insulin-induced Negative Regulator of Insulin Signaling

2000 • 454 citations

Lilly Lecture 1980: Insulin Resistance and Insulin Action: An In Vitro and In Vivo Perspective

1981 • 317 citations

Growth Hormone Preferentially Induces the Rapid, Transient Expression of SOCS-3, a Novel Inhibitor of Cytokine Receptor Signaling

1998 • 315 citations

Circulating Leptin Levels Are Modulated by Fasting, Cold Exposure and Insulin Administration in Lean but Not Zucker (fa/fa) Rats as Measured by ELISA

1996 • 307 citations

Mechanism of signaling by growth hormone receptor

1996 • 264 citations

Mechanism of Inhibition of Growth Hormone Receptor Signaling by Suppressor of Cytokine Signaling Proteins

1999 • 208 citations

The role of the growth hormone (GH) receptor and JAK1 and JAK2 kinases in the activation of Stats 1, 3, and 5 by GH.

1996 • 198 citations

Impaired JAK-STAT signal transduction contributes to growth hormone resistance in chronic uremia

2001 • 177 citations

Domains of the growth hormone receptor required for association and activation of JAK2 tyrosine kinase.

1994 • 171 citations

STAT5b Is Required for GH-Induced Liver Igf-I Gene Expression

2001 • 167 citations

Plasma somatomedin-C in fasted and refed rats: close relationship with changes in liver somatogenic but not lactogenic binding sites

1983 • 153 citations

Growth Hormone Regulation of SOCS-2, SOCS-3, and CIS Messenger Ribonucleic Acid Expression in the Rat*

1999 • 143 citations

Growth Hormone (GH) Regulation of Cytochrome P-450IIC12, Insulin-Like Growth Factor-I (IGF-I), and GH Receptor Messenger RNA Expression in Primary Rat Hepatocytes: A Hormonal Interplay with Insulin, IGF-I, and Thyroid Hormone

1990 • 128 citations

Interaction of the growth hormone receptor cytoplasmic domain with the JAK2 tyrosine kinase.

1994 • 127 citations

Dual effects of suppressor of cytokine signaling (SOCS‐2) on growth hormone signal transduction

1999 • 127 citations

Interactions of polypeptide hormones with cell membrane specific receptors: Studies with insulin and glucagon

1976 • 122 citations

The role of the growth hormone (GH) receptor and JAK1 and JAK2 kinases in the activation of Stats 1, 3, and 5 by GH

1996 • 122 citations

Identification of the Origin of the Growth Hormone-Binding Protein in Rat Serum

1990 • 111 citations

Cellular mechanisms in the processing of growth hormone and its receptor

1989 • 97 citations

GH insensitivity induced by endotoxin injection is associated with decreased liver GH receptors

1999 • 92 citations

Growth Hormone (GH)-induced Dimerization Inhibits Phorbol Ester-stimulated GH Receptor Proteolysis

2001 • 91 citations

Low Plasma Somatomedin-C in Streptozotocin-induced Diabetes Mellitus: Correlation with Changes in Somatogenic and Lactogenic Liver Binding Sites

1983 • 89 citations

Endotoxin-Induced Inhibition of Growth Hormone Receptor Signaling in Rat Liver in Vivo1

1999 • 86 citations

The effect of fasting on liver receptors for prolactin and growth hormone

1981 • 84 citations

Insulin Inhibits Growth Hormone Signaling via the Growth Hormone Receptor/JAK2/STAT5B Pathway

1999 • 83 citations

Growth hormone stimulates tyrosine phosphorylation of JAK2 and STAT5, but not insulin receptor substrate-1 or SHC proteins in liver and skeletal muscle of normal rats in vivo.

1996 • 76 citations

The decreased plasma concentration of insulin-like growth factor-I in protein-restricted rats is not due to decreased numbers of growth hormone receptors on isolated hepatocytes

1990 • 67 citations

Growth Hormone-Dependent Tyrosine Phosphorylation of a GH Receptor-Associated High Molecular WEIGHT Protein Immunologically Related to JAK2

1998 • 62 citations

Growth Hormone Stimulates the Tyrosine Kinase Activity of JAK2 and Induces Tyrosine Phosphorylation of Insulin Receptor Substrates and Shc in Rat Tissues**This work was supported by Fundaćao de Amparo a Pesquisa do Estado de São Paulo and Conselho Nacional de Pesquisa (PRONEX).

1999 • 61 citations

Decreases in growth hormone receptor signal transduction contribute to the decline in insulin-like growth factor I gene expression with age.

1995 • 61 citations

Potentiation of Growth Hormone-Induced Liver Suppressors of Cytokine Signaling Messenger Ribonucleic Acid by Cytokines¹

2000 • 60 citations

Growth hormone receptors in rat liver membranes: Effects of fasting and refeeding, and correlation with plasma somatomedin activity

1982 • 53 citations

Activation of the Signal Transducers and Activators of Transcription Signaling Pathway by Growth Hormone (GH) in Skin Fibroblasts from Normal and GH Binding Protein-Positive Laron Syndrome Children

1998 • 52 citations

Effect of dietary protein restriction on liver transcription factors

1996 • 46 citations

Growth hormone induces insulin‐like growth factor‐I gene transcription by a synergistic action of STAT5 and HNF‐1α

1999 • 46 citations

Phorbol Ester- and Growth Factor-Induced Growth Hormone (GH) Receptor Proteolysis and GH-Binding Protein Shedding: Relationship to GH Receptor Down-Regulation¹

2001 • 46 citations

Dexamethasone inhibits both growth hormone (GH)-induction of insulin-like growth factor-I (IGF-I) mRNA and GH receptor (GHR) mRNA levels in rat primary cultured hepatocytes

1999 • 45 citations

Insulin and insulin-like growth factor-I acutely inhibit surface translocation of growth hormone receptors in osteoblasts: A novel mechanism of growth hormone receptor regulation

1997 • 43 citations

Requirement of Tyrosine Residues 333 and 338 of the Growth Hormone (GH) Receptor for Selected GH-stimulated Function

1995 • 40 citations

Dexamethasone-induced antagonism of growth hormone (GH) action by down-regulation of GH binding in 3T3-F442A fibroblasts.

1995 • 37 citations

Regulation of Glucose Transport and c-fos and egr-1 Expression in Cells with Mutated or Endogenous Growth Hormone Receptors*

1998 • 34 citations

Distinct Cytoplasmic Domains of the Growth Hormone Receptor Are Required for Glucocorticoid- and Phorbol Ester-induced Decreases in Growth Hormone (GH) Binding

1996 • 30 citations

REGULATION OF GLUCOSE TRANSPORT**Supported by grants from the National Institutes of Health and the Life Insurance Medical Research Fund.

1965 • 25 citations

Platelet-derived Growth Factor and Lysophosphatidic Acid Inhibit Growth Hormone Binding and Signaling via a Protein Kinase C-dependent Pathway

2000 • 24 citations

Hypophysectomy or Adrenalectomy of Rats with Insulin-Dependent Diabetes Mellitus Partially Restores Their Responsiveness to Growth Hormone

1994 • 16 citations