Phorbol Ester- and Growth Factor-Induced Growth Hormone (GH) Receptor Proteolysis and GH-Binding Protein Shedding: Relationship to GH Receptor Down-Regulation¹

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

1997 • 3,094 citations

Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase

1998 • 3,026 citations

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α

1997 • 1,608 citations

An Essential Role for Ectodomain Shedding in Mammalian Development

1998 • 1,607 citations

Growth hormone receptor and serum binding protein: purification, cloning and expression

1987 • 1,540 citations

SRα Promoter: an Efficient and Versatile Mammalian cDNA Expression System Composed of the Simian Virus 40 Early Promoter and the R-U5 Segment of Human T-Cell Leukemia Virus Type 1 Long Terminal Repeat

1988 • 1,351 citations

Soluble receptors for cytokines and growth factors: generation and biological function

1994 • 766 citations

The metzincins — Topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a super family of zinc‐peptidases

1995 • 691 citations

Membrane protein secretases

1997 • 634 citations

Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing

1994 • 607 citations

A metalloprotease-disintegrin, MDC9/meltrin-gamma /ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor

1998 • 523 citations

Mode of Action of Pituitary Growth Hormone on Target Cells

1985 • 452 citations

A Specific Growth Hormone-Binding Protein in Human Plasma: Initial Characterization*

1986 • 424 citations

Processing of the Notch Ligand Delta by the Metalloprotease Kuzbanian

1999 • 413 citations

The growth hormone-binding protein in rat serum is an alternatively spliced form of the rat growth hormone receptor.

1989 • 399 citations

Regulation of receptor concentration by homologous hormone. Effect of human growth hormone on its receptor in IM-9 lymphocytes.

1976 • 364 citations

Mouse Serum Growth Hormone (GH) Binding Protein has GH Receptor Extracellular and Substituted Transmembrane Domains

1989 • 305 citations

Ectodomain shedding of TGF-alpha and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascades

1999 • 248 citations

A Short Isoform of the Human Growth Hormone Receptor Functions as a Dominant Negative Inhibitor of the Full-Length Receptor and Generates Large Amounts of Binding Protein

1997 • 215 citations

The Shedding of Membrane-anchored Heparin-binding Epidermal-like Growth Factor Is Regulated by the Raf/Mitogen-activated Protein Kinase Cascade and by Cell Adhesion and Spreading

1999 • 185 citations

The Circulating Growth Hormone (GH)-Binding Protein Complex: A Major Constituent of Plasma GH in Man*

1988 • 172 citations

Domains of the growth hormone receptor required for association and activation of JAK2 tyrosine kinase.

1994 • 171 citations

Involvement of the Src Homology 2-containing Tyrosine Phosphatase SHP-2 in Growth Hormone Signaling

1998 • 163 citations

Alternatively spliced forms in the cytoplasmic domain of the human growth hormone (GH) receptor regulate its ability to generate a soluble GH-binding protein.

1996 • 145 citations

Regulation of plasma growth hormone-binding proteins in health and disease

1989 • 145 citations

Release of Growth Hormone Binding Protein from IM-9 Lymphocytes by Endopeptidase is Dependent on Sulfydryl Group Inactivation*

1988 • 133 citations

Distinct cytoplasmic regions of the growth hormone receptor are required for activation of JAK2, mitogen-activated protein kinase, and transcription.

1994 • 120 citations

Identification of the Origin of the Growth Hormone-Binding Protein in Rat Serum

1990 • 111 citations

Regulation of Secretion of Alzheimer Amyloid Precursor Protein by the Mitogen‐Activated Protein Kinase Cascade

1998 • 109 citations

Disulfide Linkage of Growth Hormone (GH) Receptors (GHR) Reflects GH-induced GHR Dimerization

1999 • 99 citations

Growth hormone receptor cytoplasmic domain differentially promotes tyrosine phosphorylation of signal transducers and activators of transcription 5b and 3 by activated JAK2 kinase.

1996 • 90 citations

Phosphorylation of Highly Purified Growth Hormone Receptors by a Growth Hormone Receptor-associated Tyrosine Kinase

1989 • 89 citations

Insulin Inhibits Growth Hormone Signaling via the Growth Hormone Receptor/JAK2/STAT5B Pathway

1999 • 83 citations

Growth hormone-binding proteins: state of the art

1994 • 80 citations

Blockade of Growth Hormone Receptor Shedding by a Metalloprotease Inhibitor*

1998 • 72 citations

Growth Hormone-dependent Differentiation of 3T3-F442A Preadipocytes Requires Janus Kinase/Signal Transducer and Activator of Transcription but Not Mitogen-activated Protein Kinase or p70 S6 Kinase Signaling

1999 • 67 citations

Growth Hormone-Dependent Tyrosine Phosphorylation of a GH Receptor-Associated High Molecular WEIGHT Protein Immunologically Related to JAK2

1998 • 62 citations

Growth Hormone-induced Alteration in ErbB-2 Phosphorylation Status in 3T3-F442A Fibroblasts

1999 • 60 citations

The serum growth hormone binding protein: pregnant with possibilities

1997 • 58 citations

Monkey Growth Hormone (GH) Receptor Gene Expression

1997 • 56 citations

Treatment of IM-9 cells with human growth hormone (GH) promotes rapid disulfide linkage of the GH receptor.

1994 • 50 citations

Control of growth hormone (GH) binding protein release from human hepatoma cells expressing full-length GH receptor.

1995 • 43 citations

Insulin and insulin-like growth factor-I acutely inhibit surface translocation of growth hormone receptors in osteoblasts: A novel mechanism of growth hormone receptor regulation

1997 • 43 citations

Water-Soluble Specific Growth Hormone Binding Sites from Cultured Human Lymphocytes: Preparation and Partial Characterization

1976 • 37 citations

Human growth hormone-stimulated growth of human cultured lymphocytes (IM-9) and its inhibition by phorbol diesters through down-regulation of the hormone receptors. Possible involvement of phosphorylation of a 55,000 molecular weight protein associated with the receptor in the down-regulation.

1990 • 36 citations

Distinct Cytoplasmic Domains of the Growth Hormone Receptor Are Required for Glucocorticoid- and Phorbol Ester-induced Decreases in Growth Hormone (GH) Binding

1996 • 30 citations

Platelet-derived Growth Factor and Lysophosphatidic Acid Inhibit Growth Hormone Binding and Signaling via a Protein Kinase C-dependent Pathway

2000 • 24 citations

Growth hormone induces detergent insolubility of GH receptors in IM-9 cells

1997 • 23 citations

The Human Growth Hormone (GH) Receptor and Its Truncated Isoform: Sulfhydryl Group Inactivation in the Study of Receptor Internalization and GH-Binding Protein Generation

1999 • 16 citations

Activation of protein kinase Cα enhances human growth hormone-binding protein release

1998 • 13 citations

Deletion of the mouse GH-binding protein (mGHBP) mRNA polyadenylation and splicing sites does not abolish production of mGHBP

1997 • 12 citations