Potentiation of Growth Hormone-Induced Liver Suppressors of Cytokine Signaling Messenger Ribonucleic Acid by Cytokines¹

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

1998 • 2,072 citations

A family of cytokine-inducible inhibitors of signalling

1997 • 2,055 citations

A new protein containing an SH2 domain that inhibits JAK kinases

1997 • 1,413 citations

Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses

1998 • 1,316 citations

Structure and function of a new STAT-induced STAT inhibitor

1997 • 1,308 citations

Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression

1997 • 989 citations

The Role of SOCS-3 in Leptin Signaling and Leptin Resistance

1999 • 640 citations

A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6.

1995 • 425 citations

Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: role of Stat5 in proliferation.

1996 • 414 citations

Septic Autocannibalism

1980 • 326 citations

Growth Hormone Preferentially Induces the Rapid, Transient Expression of SOCS-3, a Novel Inhibitor of Cytokine Receptor Signaling

1998 • 315 citations

Critically ill patients have high basal growth hormone levels with attenuated oscillatory activity associated with low levels of insulin–like growth factor‐I

1991 • 286 citations

Suppression of STAT5 Functions in Liver, Mammary Glands, and T Cells in Cytokine-Inducible SH2-Containing Protein 1 Transgenic Mice

1999 • 269 citations

Mechanism of Inhibition of Growth Hormone Receptor Signaling by Suppressor of Cytokine Signaling Proteins

1999 • 208 citations

LPS and TNFα induce SOCS3 mRNA and inhibit IL‐6‐induced activation of STAT3 in macrophages

1999 • 205 citations

Anabolic effects of recombinant human growth hormone in patients with wasting associated with human immunodeficiency virus infection.

1993 • 200 citations

Insulinlike Growth Factor 1 Production Is Inhibited in Human Sepsis

1988 • 198 citations

Insulin-like growth factor I exerts growth hormone- and insulin-like actions on human muscle protein metabolism

1994 • 186 citations

Inhibition by Interleukin-1β and Tumor Necrosis Factor-α of the Insulin-Like Growth Factor I Messenger Ribonucleic Acid Response to Growth Hormone in Rat Hepatocyte Primary Culture*

1997 • 184 citations

The Interleukin 1 Receptor: Ligand Interactions and Signal Transduction

1998 • 178 citations

Regulation of insulin-like growth factor-I (IGF-I) and IGF-binding proteins by tumor necrosis factor

1995 • 172 citations

Critical illness is associated with low circulating concentrations of insulin-like growth factors-I and -II, alterations in insulin-like growth factor binding proteins, and induction of an insulin-like growth factor binding protein 3 protease

1996 • 162 citations

A Sequence of the CIS Gene Promoter Interacts Preferentially with Two Associated STAT5A Dimers: a Distinct Biochemical Difference between STAT5A and STAT5B

1998 • 160 citations

Growth Hormone Regulation of SOCS-2, SOCS-3, and CIS Messenger Ribonucleic Acid Expression in the Rat*

1999 • 143 citations

Differential tissue regulation of insulin-like growth factor-I content and binding proteins after endotoxin.

1994 • 138 citations

The SOCS proteins: a new family of negative regulators of signal transduction

1998 • 135 citations

Regulation of insulin-like growth factor (IGF)-I mRNA and peptide and IGF-binding proteins by interleukin-1

1996 • 131 citations

Dual effects of suppressor of cytokine signaling (SOCS‐2) on growth hormone signal transduction

1999 • 127 citations

Proinflammatory cytokines interleukin 1β and tumor necrosis factor α inhibit growth hormone stimulation of insulin-like growth factor I synthesis and growth hormone receptor mRNA levels in cultured rat liver cells

1996 • 126 citations

The Metabolic Response to Injury and Its Nutritional Implications: Retrospect and Prospect

1979 • 123 citations

Differential regulation of insulin-like growth factor I (IGF-I) and IGF binding protein-1 messenger ribonucleic acids by amino acid availability and growth hormone in rat hepatocyte primary culture.

1994 • 118 citations

Prolactin Activates Tyrosyl Phosphorylation of Insulin Receptor Substrate 1 and Phosphatidylinositol-3-OH Kinase

1997 • 103 citations

Activation of SOCS-3 Messenger Ribonucleic Acid in the Hypothalamus by Ciliary Neurotrophic Factor¹

1999 • 103 citations

Wasting in the acquired immune deficiency syndrome is associated with multiple defects in the serum insulin-like growth factor system

1996 • 99 citations

Second annual Jonathan E. Rhoads Lecture. The metabolic response to injury and its nutritional implications: retrospect and prospect

1979 • 95 citations

Tyrosine Docking Sites of the Rat Prolactin Receptor Required for Association and Activation of Stat5

1997 • 95 citations

Evidence That Pretranslational and Translational Defects Decrease Serum Insulin-Like Growth Factor-I Concentrations during Dietary Protein Restriction*

1991 • 94 citations

GH insensitivity induced by endotoxin injection is associated with decreased liver GH receptors

1999 • 92 citations

Pituitary Corticotroph SOCS-3: Novel Intracellular Regulation of Leukemia-Inhibitory Factor-Mediated Proopiomelanocortin Gene Expression and Adrenocorticotropin Secretion

1998 • 89 citations

Endotoxin-Induced Inhibition of Growth Hormone Receptor Signaling in Rat Liver in Vivo1

1999 • 86 citations

A Novel STAT-Like Factor Mediates Lipopolysaccharide, Interleukin 1 (IL-1), and IL-6 Signaling and Recognizes a Gamma Interferon Activation Site-Like Element in the IL1B Gene

1996 • 82 citations

Down-Regulation of Liver JAK2-STAT5b Signaling by the Female Plasma Pattern of Continuous Growth Hormone Stimulation

1999 • 75 citations

Binding of STAT5a and STAT5b to a Single Element Resembling a γ-Interferon-Activated Sequence Mediates the Growth Hormone Induction of the Mouse Acid-Labile Subunit Promoter in Liver Cells

1998 • 67 citations

Mechanism of Inhibition of Growth Hormone Receptor Signaling by Suppressor of Cytokine Signaling Proteins

1999 • 61 citations

cis-Acting elements controlling transcription from rat serine protease inhibitor 2.1 gene promoter. Characterization of two growth hormone response sites and a dominant purine-rich element.

1994 • 49 citations

Hepatocyte growth factor/scatter factor (HGF/SF) signals via the STAT3/APRF transcription factor in human hepatoma cells and hepatocytes

1997 • 48 citations

Inhibition by Interleukin-1 and Tumor Necrosis Factor- of the Insulin-Like Growth Factor I Messenger Ribonucleic Acid Response to Growth Hormone in Rat Hepatocyte Primary Culture

1997 • 45 citations

Differential tissue regulation of insulin-like growth factor-I content and binding proteins after endotoxin

1994 • 43 citations

Growth Hormone Regulation of SOCS-2, SOCS-3, and CIS Messenger Ribonucleic Acid Expression in the Rat

1999 • 39 citations

Cis desensitizes GH induced Stat5 signaling in rat liver cells

1999 • 36 citations

Transcription of the Rat Serine Protease Inhibitor 2.1 Gene in Vivo: Correlation with GAGA Box Promoter Occupancy and Mechanism of Cytokine-Mediated Down-Regulation

1998 • 34 citations

Contrasting Effects of Growth Hormone and Insulin-Like Growth Factor I on the Biological Activities of Endotoxin in the Rat¹

1997 • 33 citations

Regulation of Spi 2.1 and 2.2 gene expression after turpentine inflammation: discordant responses to IL-6

1999 • 32 citations

Effects of Insulin-Like Growth Factor I Combined with Growth Hormone on Glucocorticoid-Induced Whole-Body Protein Catabolism in Man¹

1997 • 30 citations

Endotoxin-Induced Inhibition of Growth Hormone Receptor Signaling in Rat Liver in Vivo

1999 • 29 citations

Pituitary Corticotroph SOCS-3: Novel Intracellular Regulation of Leukemia-Inhibitory Factor-Mediated Proopiomelanocortin Gene Expression and Adrenocorticotropin Secretion

1998 • 29 citations

Activation of SOCS-3 Messenger Ribonucleic Acid in the Hypothalamus by Ciliary Neurotrophic Factor

1999 • 28 citations

Decreased acid-labile subunit (ALS) levels by endotoxin in vivo and by interleukin-1β in vitro

1998 • 27 citations

Effects of Insulin-Like Growth Factor I Combined with Growth Hormone on Glucocorticoid-Induced Whole-Body Protein Catabolism in Man

1997 • 23 citations

Down-Regulation of Liver JAK2-STAT5b Signaling by the Female Plasma Pattern of Continuous Growth Hormone Stimulation

1999 • 20 citations

Interleukin‐1β activates a short STAT‐3 isoform in clonal insulin‐secreting cells

1999 • 18 citations

Binding of STAT5a and STAT5b to a Single Element Resembling a -Interferon-Activated Sequence Mediates the Growth Hormone Induction of the Mouse Acid-Labile Subunit Promoter in Liver Cells

1998 • 15 citations

Contrasting Effects of Growth Hormone and Insulin-Like Growth Factor I on the Biological Activities of Endotoxin in the Rat

1997 • 13 citations