Role of NMDA receptors and MAP kinase in the amygdala in extinction of fear: clinical implications for exposure therapy*

Facilitation of Conditioned Fear Extinction by Systemic Administration or Intra-Amygdala Infusions of d-Cycloserine as Assessed with Fear-Potentiated Startle in Rats

2002 • 807 citations

Blocking of acquisition but not expression of conditioned fear-potentiated startle by NMDA antagonists in the amygdala

1990 • 806 citations

Calcium Influx via the NMDA Receptor Induces Immediate Early Gene Transcription by a MAP Kinase/ERK-Dependent Mechanism

1996 • 781 citations

Extinction of fear-potentiated startle: blockade by infusion of an NMDA antagonist into the amygdala

1992 • 682 citations

Activation of ERK/MAP Kinase in the Amygdala Is Required for Memory Consolidation of Pavlovian Fear Conditioning

2000 • 660 citations

Memory Consolidation of Auditory Pavlovian Fear Conditioning Requires Protein Synthesis and Protein Kinase A in the Amygdala

2000 • 594 citations

A Synaptic Ras-GTPase Activating Protein (p135 SynGAP) Inhibited by CaM Kinase II

1998 • 578 citations

Activation of p42 Mitogen-activated Protein Kinase in Hippocampal Long Term Potentiation

1996 • 575 citations

Lesions of the amygdala, but not of the cerebellum or red nucleus, block conditioned fear as measured with the potentiated startle paradigm.

1986 • 506 citations

A role for the Ras signalling pathway in synaptic transmission and long-term memory

1997 • 474 citations

Lesions of the amygdala, but not of the cerebellum or red nucleus, block conditioned fear as measured with the potentiated startle paradigm.

1986 • 407 citations

Acquisition of contextual Pavlovian fear conditioning is blocked by application of an NMDA receptor antagonist D,L-2-amino-5-phosphonovaleric acid to the basolateral amygdala.

1994 • 358 citations

The role of amygdala glutamate receptors in fear learning, fear-potentiated startle, and extinction

2002 • 354 citations

Intra-Amygdala Blockade of the NR2B Subunit of the NMDA Receptor Disrupts the Acquisition But Not the Expression of Fear Conditioning

2001 • 340 citations

Acquisition of contextual Pavlovian fear conditioning is blocked by application of an NMDA receptor antagonist D,L-2-amino-5-phosphonovaleric acid to the basolateral amygdala.

1994 • 318 citations

Amygdalar NMDA Receptors are Critical for New Fear Learning in Previously Fear-Conditioned Rats

1998 • 309 citations

Both Protein Kinase A and Mitogen-Activated Protein Kinase Are Required in the Amygdala for the Macromolecular Synthesis-Dependent Late Phase of Long-Term Potentiation

2000 • 275 citations

Modification of the startle reflex in the rat by changes in the auditory and visual environments.

1971 • 261 citations

Intra-amygdala infusion of the N-methyl-D-aspartate receptor antagonist AP5 blocks acquisition but not expression of fear-potentiated startle to an auditory conditioned stimulus.

1992 • 256 citations

Second-order fear conditioning prevented by blocking NMDA receptors in amygdala

1997 • 243 citations

Mitogen-Activated Protein Kinase Cascade in the Basolateral Nucleus of Amygdala Is Involved in Extinction of Fear-Potentiated Startle

2001 • 221 citations

N-methyl-D-aspartate lesions of the lateral and basolateral nuclei of the amygdaloid block fear-potentiated startle and shock sensitization of startle.

1992 • 210 citations

Intra-amygdala infusion of the N-methyl-D-aspartate receptor antagonist AP5 blocks acquisition but not expression of fear-potentiated startle to an auditory conditioned stimulus.

1992 • 209 citations

Amygdalar NMDA Receptors Are Critical for the Expression of Multiple Conditioned Fear Responses

2001 • 194 citations

The NMDA antagonist MK-801 blocks the extinction of Pavlovian fear conditioning.

1996 • 170 citations

N-methyl-D-aspartate lesions of the lateral and basolateral nuclei of the amygdaloid block fear-potentiated startle and shock sensitization of startle.

1992 • 162 citations

The NMDA antagonist MK-801 blocks the extinction of Pavlovian fear conditioning.

1996 • 157 citations

Injections of the NMDA Receptor Antagonist Aminophosphonopentanoic Acid into the Lateral Nucleus of the Amygdala Block the Expression of Fear-Potentiated Startle and Freezing

2001 • 115 citations

The role of mammalian ionotropic receptors in synaptic plasticity: LTP, LTD and epilepsy

2000 • 88 citations

The NMDA receptor antagonist MK-801 blocks acquisition and extinction of conditioned hypoalgesic responses in the rat.

1994 • 74 citations