Atypical neural messengers

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

1990 • 3,304 citations

Localization of nitric oxide synthase indicating a neural role for nitric oxide

1990 • 2,996 citations

THE HEME OXYGENASE SYSTEM:A Regulator of Second Messenger Gases

1997 • 2,481 citations

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

1991 • 2,371 citations

The possible role of hydrogen sulfide as an endogenous neuromodulator

1996 • 2,123 citations

Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.

1989 • 1,850 citations

Glutamate Induces Calcium Waves in Cultured Astrocytes: Long-Range Glial Signaling

1990 • 1,820 citations

S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control

1996 • 1,604 citations

Interaction of Nitric Oxide Synthase with the Postsynaptic Density Protein PSD-95 and α1-Syntrophin Mediated by PDZ Domains

1996 • 1,589 citations

Carbon Monoxide: a Putative Neural Messenger

1993 • 1,519 citations

Protein S-nitrosylation: a physiological signal for neuronal nitric oxide

2001 • 1,391 citations

Targeted disruption of the neuronal nitric oxide synthase gene

1993 • 1,300 citations

Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin.

1992 • 1,237 citations

Nitric Oxide: A Physiologic Mediator of Penile Erection

1992 • 1,187 citations

<scp>d</scp> -Serine is an endogenous ligand for the glycine site of the N -methyl- <scp>d</scp> -aspartate receptor

2000 • 1,075 citations

Nitric Oxide as a Mediator of Relaxation of the Corpus Cavernosum in Response to Nonadrenergic, Noncholinergic Neurotransmission

1992 • 1,028 citations

Nitric oxide as an inhibitory non-adrenergic non-cholinergic neurotransmitter

1990 • 1,012 citations

Activation of the Cardiac Calcium Release Channel (Ryanodine Receptor) by Poly-S-Nitrosylation

1998 • 983 citations

Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus

2000 • 967 citations

ZINC PROTEINS: Enzymes, Storage Proteins, Transcription Factors, and Replication Proteins

1992 • 966 citations

NMDA receptor activation induces nitric oxide synthesis from arginine in rat brain slices

1989 • 912 citations

Micromolar concentrations of Zn2+ antagonize NMDA and GABA responses of hippocampal neurons

1987 • 852 citations

D-serine, an endogenous synaptic modulator: localization to astrocytes and glutamate-stimulated release.

1995 • 823 citations

Stimulation-induced uptake and release of zinc in hippocampal slices

1984 • 812 citations

ATP Released from Astrocytes Mediates Glial Calcium Waves

1999 • 794 citations

Serine racemase: A glial enzyme synthesizing <scp>d</scp> -serine to regulate glutamate- N -methyl- <scp>d</scp> -aspartate neurotransmission

1999 • 780 citations

Metabolism of amino-acids

1935 • 760 citations

ZINC AND BRAIN INJURY

1998 • 757 citations

Characterization of two constitutive forms of rat liver microsomal heme oxygenase. Only one molecular species of the enzyme is inducible.

1986 • 748 citations

Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex

1992 • 737 citations

ZnT-3, a putative transporter of zinc into synaptic vesicles

1996 • 712 citations

(S)NO Signals: Translocation, Regulation, and a Consensus Motif

1997 • 680 citations

Zinc Selectively Blocks the Action of N -Methyl-D-Aspartate on Cortical Neurons

1987 • 678 citations

High-Affinity Zinc Inhibition of NMDA NR1–NR2A Receptors

1997 • 629 citations

Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites.

1992 • 621 citations

Behavioural abnormalities in male mice lacking neuronal nitric oxide synthase

1995 • 603 citations

Cyclic GMP Phosphodiesterase-5: Target of Sildenafil

1999 • 536 citations

Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT 3 gene

1999 • 534 citations

Purification of serine racemase: Biosynthesis of the neuromodulator <scp>d</scp> -serine

1999 • 501 citations

Targeted disruption of NMDA receptor 1 gene abolishes NMDA response and results in neonatal death

1994 • 496 citations

Role of nitric oxide in gastrointestinal and hepatic function and disease

1992 • 493 citations

The Actions of Synaptically Released Zinc at Hippocampal Mossy Fiber Synapses

2000 • 477 citations

PIN: An Associated Protein Inhibitor of Neuronal Nitric Oxide Synthase

1996 • 454 citations

Signalling via ATP in the nervous system

1994 • 441 citations

Molecular basis of NMDA receptor-coupled ion channel modulation by S-nitrosylation

2000 • 417 citations

Chemical Anatomy of the Brain

1984 • 411 citations

d-Serine as a Neuromodulator: Regional and Developmental Localizations in Rat Brain Glia Resemble NMDA Receptors

1997 • 410 citations

Heme oxygenase 2: endothelial and neuronal localization and role in endothelium-dependent relaxation.

1996 • 401 citations

ATP-Mediated Glia Signaling

2000 • 391 citations

Nitric oxide-induced S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase inhibits enzymatic activity and increases endogenous ADP-ribosylation.

1992 • 390 citations

CAPON: A Protein Associated with Neuronal Nitric Oxide Synthase that Regulates Its Interactions with PSD95

1998 • 365 citations

Endogenous <scp>d</scp>‐Serine in Rat Brain: N‐Methyl‐<scp>d</scp>‐Aspartate Receptor‐Related Distribution and Aging

1993 • 350 citations

Hydrogen Sulfide Induces Cyclic AMP and Modulates the NMDA Receptor

2000 • 348 citations

VIP as a possible neurotransmitter of non-cholinergic non-adrenergic inhibitory neurones

1980 • 338 citations

The presence of free D-aspartic acid in rodents and man

1986 • 333 citations

Clearance of glutamate inside the synapse and beyond

1999 • 329 citations

Functional Comparison of <scp>d</scp>‐Serine and Glycine in Rodents: The Effect on Cloned NMDA Receptors and the Extracellular Concentration

1995 • 327 citations

Free d-aspartate and d-serine in the mammalian brain and periphery

1997 • 322 citations

Dexras1

2000 • 305 citations

Effect of zinc on NMDA receptor-mediated channel currents in cortical neurons

1990 • 302 citations

Phosphorylation by calcium calmodulin-dependent protein kinase II and protein kinase C modulates the activity of nitric oxide synthase

1991 • 275 citations

Heme Oxygenase: Clinical Applications and Functions

1992 • 264 citations

Purification and characterization of the major constitutive form of testicular heme oxygenase. The noninducible isoform.

1986 • 260 citations

Posttranslational Modification of Glyceraldehyde-3-phosphate Dehydrogenase by S-Nitrosylation and Subsequent NADH Attachment

1996 • 252 citations

Embryonic Development and Postnatal Changes in Free <scp>d</scp>‐Aspartate and <scp>d</scp>‐Serine in the Human Prefrontal Cortex

1993 • 252 citations

Carbon Monoxide: An Endogenous Modulator of the Nitric Oxide–Cyclic GMP Signaling System

1996 • 242 citations

Targeted gene deletion of heme oxygenase 2 reveals neural role for carbon monoxide

1997 • 235 citations

Anatomical Distribution and Postnatal Changes in Endogenous Free D‐Aspartate and D‐Serine in Rat Brain and Periphery

1995 • 227 citations

Nitric oxide signaling to iron-regulatory protein: direct control of ferritin mRNA translation and transferrin receptor mRNA stability in transfected fibroblasts.

1995 • 226 citations

Selective release of endogenous zinc from the hippocampal mossy fibers in situ

1987 • 220 citations

<scp>d</scp> -aspartate localizations imply neuronal and neuroendocrine roles

1997 • 218 citations

Free d-serine, d-aspartate and d-alanine in central nervous system and serum in mutant mice lacking d-amino acid oxidase

1993 • 202 citations

P2Y₁Purinoceptor-Mediated Ca²⁺Signaling and Ca²⁺Wave Propagation in Dorsal Spinal Cord Astrocytes

2000 • 195 citations

Non-adrenergic non-cholinergic relaxation mediated by nitric oxide in the canine ileocolonic junction

1990 • 185 citations

d-Aspartate disposition in neuronal and endocrine tissues: ontogeny, biosynthesis and release

2000 • 182 citations

Modulation by zinc ions of native rat and recombinant human inhibitory glycine receptors.

1995 • 180 citations

Hippocampal long-term potentiation is normal in heme oxygenase-2 mutant mice

1995 • 171 citations

The inhibition of single N‐methyl‐D‐aspartate‐activated channels by zinc ions on cultured rat neurones.

1990 • 170 citations

Four Residues of the Extracellular N-Terminal Domain of the NR2A Subunit Control High-Affinity Zn2+ Binding to NMDA Receptors

2000 • 167 citations

Spontaneous and evoked release of endogenous Zn2+ in the hippocampal mossy fiber zone of the rat in situ

1985 • 154 citations

Effect of nitric oxide on circular muscle of the canine small intestine.

1991 • 139 citations

A novel modulatory binding site for zinc on the GABAA receptor complex in cultured rat neurones.

1992 • 132 citations

IDENTIFICATION OF D‐ASPARTIC ACID IN THE BRAIN OF OCTOPUS VULGARIS LAM

1977 • 125 citations

Ejaculatory abnormalities in mice with targeted disruption of the gene for heme oxygenase-2

1998 • 115 citations

Phosphorylation of nitric oxide synthase by protein kinase A

1991 • 114 citations

Zn2+ potentiates excitatory action of ATP on mammalian neurons.

1993 • 107 citations

Noncompetitive inhibition of gamma-aminobutyric acidA channels by Zn.

1991 • 104 citations

Direct demonstration of a physiological role for carbon monoxide in olfactory receptor neurons

1995 • 103 citations

STUDIES ON THE CYCLOPHORASE SYSTEM

1949 • 100 citations

Presence of D‐aspartate in squid axoplasm and in other regions of the cephalopod nervous system

1978 • 94 citations

Widespread distribution of free <scp>d</scp>‐aspartate in rat periphery

1993 • 93 citations

The Origin and Turnover of D-Serine in Brain

1997 • 89 citations

The Regulation of Heme Turnover and Carbon Monoxide Biosynthesis in Cultured Primary Rat Olfactory Receptor Neurons

1996 • 80 citations

The iron-responsive element binding protein: a target for synaptic actions of nitric oxide.

1994 • 78 citations

A novel effect of zinc on the lobster muscle GABA receptor

1982 • 72 citations

Modulation by nitric oxide of metalloprotein regulatory activities

1996 • 70 citations

Aggressive behavior in male mice lacking the gene for neuronal nitric oxide synthase requires testosterone

1997 • 64 citations

Zinc Uptake into Synaptosomes

1988 • 64 citations

Currents Activated by GABA and their Modulation by Zn²⁺ in Cerebellar Granule Cells in Culture

1993 • 46 citations

Properties of ATP-gated channels recorded from rat sympathetic neurons: voltage dependence and regulation by Zn2+ ions

1995 • 45 citations