The Role of Osteopontin in the Development of Granulomatous Lesions in Lung

Eta-1 (Osteopontin): An Early Component of Type-1 (Cell-Mediated) Immunity

2000 • 1,104 citations

Osteopontin: a protein with diverse functions

1993 • 1,082 citations

Cloning and sequence analysis of rat bone sialoprotein (osteopontin) cDNA reveals an Arg-Gly-Asp cell-binding sequence.

1986 • 1,078 citations

MHC class I-cestricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses

1994 • 619 citations

Egg deposition is the major stimulus for the production of Th2 cytokines in murine schistosomiasis mansoni.

1991 • 542 citations

Expression and distribution of osteopontin in human tissues: widespread association with luminal epithelial surfaces.

1992 • 459 citations

Costimulation of Fibroblast Collagen and Transforming Growth Factor β1 Gene Expression by Monocyte Chemoattractant Protein-1 via Specific Receptors

1996 • 427 citations

Evidence for a role of osteopontin in macrophage infiltration in response to pathological stimuli in vivo.

1998 • 368 citations

cDNA cloning, mRNA distribution and heterogeneity, chromosomal location, and RFLP analysis of human osteopontin (OPN)

1990 • 361 citations

CD44 variants but not CD44s cooperate with beta1-containing integrins to permit cells to bind to osteopontin independently of arginine-glycine-aspartic acid, thereby stimulating cell motility and chemotaxis.

1999 • 321 citations

Structural and functional studies of the early T lymphocyte activation 1 (Eta-1) gene. Definition of a novel T cell-dependent response associated with genetic resistance to bacterial infection.

1989 • 319 citations

Identification of the Syrian hamster cardiomyopathy gene

1997 • 274 citations

Osteopontin Is Associated with T Cells in Sarcoid Granulomas and Has T Cell Adhesive and Cytokine-Like Properties In Vitro

1999 • 240 citations

Osteopontin, a transformation-associated cell adhesion phosphoprotein, is induced by 12-O-tetradecanoylphorbol 13-acetate in mouse epidermis

1989 • 238 citations

Transfer of granulocyte-macrophage colony-stimulating factor gene to rat lung induces eosinophilia, monocytosis, and fibrotic reactions.

1996 • 229 citations

Molecular and cellular basis of genetic resistance to bacterial infection: the role of the early T-lymphocyte activation-1/osteopontin gene.

1993 • 207 citations

Transcriptional regulation of osteopontin production in rat osteosarcoma cells by type beta transforming growth factor.

1988 • 206 citations

A chemoattractant cytokine associated with granulomas in tuberculosis and silicosis

1997 • 188 citations

Osteopontin inhibits induction of nitric oxide synthase gene expression by inflammatory mediators in mouse kidney epithelial cells.

1994 • 178 citations

Glucocorticoids Increase Osteopontin Expression in Cardiac Myocytes and Microvascular Endothelial Cells

1995 • 175 citations

SPONTANEOUS, HEREDITARY MYOCARDIAL DEGENERATION AND CONGESTIVE HEART FAILURE IN A STRAIN OF SYRIAN HAMSTERS*

1969 • 159 citations

Cellular and Molecular Aspects of Granulomatous Inflammation

1989 • 143 citations

Expression of Osteopontin in Kupffer Cells and Hepatic Macrophages and Stellate Cells in Rat Liver after Carbon Tetrachloride Intoxication: A Possible Factor for Macrophage Migration into Hepatic Necrotic Areas

1999 • 142 citations

Cytokine responses during mycobacterial and schistosomal antigen-induced pulmonary granuloma formation. Production of Th1 and Th2 cytokines and relative contribution of tumor necrosis factor.

1994 • 128 citations

Overexpression of granulocyte-macrophage colony-stimulating factor induces pulmonary granulation tissue formation and fibrosis by induction of transforming growth factor-beta 1 and myofibroblast accumulation.

1997 • 124 citations

Molecular Pathogenesis of Muscle Degeneration in the δ-Sarcoglycan-Deficient Hamster

1998 • 109 citations

Adenovirus-mediated cytokine gene transfer at tissue sites. Overexpression of IL-6 induces lymphocytic hyperplasia in the lung.

1994 • 106 citations

Pulmonary Diseases and Disorders

1989 • 85 citations

Osteopontin, a Coordinator of Host Defense System: a Cytokine or an Extracellular Adhesive Protein?

1997 • 83 citations

Osteopontin is strongly expressed by histiocytes in granulomas of diverse etiology.

1997 • 77 citations

The cDNA cloning and RNA distribution of bovine osteopontin

1991 • 72 citations

Expression of inducible nitric oxide synthase and its involvement in pulmonary granulomatous inflammation in rats.

1996 • 70 citations

Evolving T cell responses in murine schistosomiasis. Th2 cells mediate secondary granulomatous hypersensitivity and are regulated by CD8+ T cells in vivo.

1993 • 69 citations

Osteopontin Expression Is Increased in the Heritable Cardiomyopathy of Syrian Hamsters

1995 • 65 citations

Construction of recombinant human type 5 adenoviruses expressing rodent IL-6 genes. An approach to investigate in vivo cytokine function.

1993 • 64 citations

Full length cDNA sequence of porcine secreted phosphoprotein-I (SPP-I, osteopontin)

1989 • 61 citations

Collagen Deposition in a Non-Fibrotic Lung Granuloma Model after Nitric Oxide Inhibition

1998 • 57 citations

Osteopontin inhibits inducible nitric oxide synthase activity in rat vascular tissue

1998 • 55 citations

Persistent and Secondary Adenovirus-Mediated Hepatic Gene Expression Using Adenovirus Vector Containing CTLA4IgG

1998 • 54 citations

Alteration of the cytokine phenotype in an experimental lung granuloma model by inhibiting nitric oxide.

1997 • 52 citations

Non-RGD domains of osteopontin promote cell adhesion without involving αv integrins

1996 • 50 citations

Chronic Effects of Enalapril and Amlodipine on Cardiac Remodeling in Cardiomyopathic Hamster Hearts

1998 • 44 citations

The role of the B7-1a molecule, an alternatively spliced form of murine B7-1 (CD80), on T cell activation.

1996 • 31 citations

In vivo expression of monokine and inducible nitric oxide synthase in experimentally induced pulmonary granulomatous inflammation. Evidence for sequential production of interleukin-1, inducible nitric oxide synthase, and tumor necrosis factor.

1995 • 29 citations

In Vivo Cytokine Gene Expression in Various T Cell Subsets of the Autoimmune MRL/Mp-lpr/lpr Mouse

1994 • 25 citations

Detection of Various Epitopes of Murine Osteopontin by Monoclonal Antibodies

1999 • 11 citations

Animal Model Molecular Pathogenesis of Muscle Degeneration in the d-Sarcoglycan-Deficient Hamster

1998 • 5 citations

Lipidosis of Pulmonary Macrophages in the Dystrophic Hamster

1985 • 3 citations