Interferon Regulatory Factor 7 Regulates Expression of Epstein-Barr Virus Latent Membrane Protein 1: a Regulatory Circuit

Epstein-Barr Virus

1986 • 2,255 citations

Epstein-Barr virus and its replication

1996 • 1,621 citations

Distinct and Essential Roles of Transcription Factors IRF-3 and IRF-7 in Response to Viruses for IFN-α/β Gene Induction

2000 • 1,304 citations

Induction of bcl-2 expression by epstein-barr virus latent membrane protein 1 protects infected B cells from programmed cell death

1991 • 1,195 citations

Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7

1998 • 1,040 citations

Epstein-Barr virus latent membrane protein (LMP1) and nuclear proteins 2 and 3C are effectors of phenotypic changes in B lymphocytes: EBNA-2 and LMP1 cooperatively induce CD23

1990 • 585 citations

Interferon regulatory factors: the next generation

1999 • 550 citations

The interferon-α/β system in antiviral responses: a multimodal machinery of gene regulation by the IRF family of transcription factors

2002 • 481 citations

The growing family of interferon regulatory factors

1997 • 480 citations

Latent membrane protein 1of Epstein-Barr virus mimics a constitutively active receptor molecule

1997 • 433 citations

Epstein-Barr virus nuclear antigen 2 transactivates latent membrane protein LMP1

1990 • 319 citations

Immediate-early gene region of human cytomegalovirus trans-activates the promoter of human immunodeficiency virus.

1987 • 317 citations

Review: On the Role of IRF in Host Defense

2002 • 314 citations

Characterization of the Interferon Regulatory Factor-7 and Its Potential Role in the Transcription Activation of Interferon A Genes

1998 • 295 citations

Induction of IRF‐3/‐7 kinase and NF‐κB in response to double‐stranded RNA and virus infection: common and unique pathways

2001 • 261 citations

Induction of cyclooxygenase-2 by Epstein–Barr virus latent membrane protein 1 is involved in vascular endothelial growth factor production in nasopharyngeal carcinoma cells

2001 • 260 citations

IRF-7, a New Interferon Regulatory Factor Associated with Epstein-Barr Virus Latency

1997 • 253 citations

Epstein-Barr virus nuclear protein 2 transactivation of the latent membrane protein 1 promoter is mediated by J kappa and PU.1

1995 • 250 citations

Multiple Regulatory Domains Control IRF-7 Activity in Response to Virus Infection

2000 • 233 citations

The expression of matrix metalloproteinase 9 is enhanced by Epstein–Barr virus latent membrane protein 1

1998 • 230 citations

Role of the TRAF Binding Site and NF-κB Activation in Epstein-Barr Virus Latent Membrane Protein 1-Induced Cell Gene Expression

1998 • 229 citations

IRF3 and IRF7 Phosphorylation in Virus-infected Cells Does Not Require Double-stranded RNA-dependent Protein Kinase R or IκB Kinase but Is Blocked by Vaccinia Virus E3L Protein

2001 • 223 citations

Epstein–Barr virus nuclear protein 2 interacts with p300, CBP, and PCAF histone acetyltransferases in activation of the LMP1 promoter

2000 • 216 citations

Epstein-Barr virus nuclear protein LP stimulates EBNA-2 acidic domain-mediated transcriptional activation

1997 • 187 citations

Regulation of the Promoter Activity of Interferon Regulatory Factor-7 Gene

2000 • 160 citations

EBNA-2 transactivates a lymphoid-specific enhancer in the BamHI C promoter of Epstein-Barr virus

1991 • 158 citations

Phosphorylation-Induced Dimerization of Interferon Regulatory Factor 7 Unmasks DNA Binding and a Bipartite Transactivation Domain

2000 • 142 citations

EBNA-2 upregulation of Epstein-Barr virus latency promoters and the cellular CD23 promoter utilizes a common targeting intermediate, CBF1

1994 • 132 citations

Virus-induced Heterodimer Formation betweenIRF-5 and IRF-7 Modulates Assembly of theIFNA Enhanceosome in Vivo and Transcriptional Activity of IFNA Genes

2003 • 117 citations

A Novel Interferon Regulatory Factor (IRF), IRF-10, Has a Unique Role in Immune Defense and Is Induced by the v-Rel Oncoprotein

2002 • 106 citations

Epstein-Barr Virus Nuclear Antigen 3C Putative Repression Domain Mediates Coactivation of the LMP1 Promoter with EBNA-2

2002 • 90 citations

Analysis of Functional Domains of Interferon Regulatory Factor 7 and Its Association with IRF-3

2001 • 89 citations

Interferon Regulatory Factor 7 Is Induced by Epstein-Barr Virus Latent Membrane Protein 1

2000 • 89 citations

Monocyte Differentiation to Macrophage Requires Interferon Regulatory Factor 7

2001 • 88 citations

Epstein-barr virus latent membrane protein 1 induces and causes release of fibroblast growth factor-2.

2002 • 83 citations

Regulation of matrix metalloproteinase-1 by Epstein-Barr virus proteins.

2003 • 80 citations

Sequence and Functional Analysis of EBNA-LP and EBNA2 Proteins from Nonhuman Primate Lymphocryptoviruses

2000 • 78 citations

An ATF/CRE Element Mediates both EBNA2-Dependent and EBNA2-Independent Activation of the Epstein-Barr Virus LMP1 Gene Promoter

1998 • 76 citations

Intracellular Signaling Molecules Activated by Epstein-Barr Virus for Induction of Interferon Regulatory Factor 7

2001 • 75 citations

Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth

1998 • 71 citations

PU box-binding transcription factors and a POU domain protein cooperate in the Epstein--Barr virus (EBV) nuclear antigen 2-induced transactivation of the EBV latent membrane protein 1 promoter

1995 • 71 citations

TRAF1 Is a Critical Regulator of JNK Signaling by the TRAF-Binding Domain of the Epstein-Barr Virus-Encoded Latent Infection Membrane Protein 1 but Not CD40

2002 • 65 citations

Stimulation of IRF-7 Gene Expression by Tumor Necrosis Factor α

2002 • 63 citations

Interferon Regulatory Factor 7 Mediates Activation of Tap-2 by Epstein-Barr Virus Latent Membrane Protein 1

2001 • 62 citations

Interferon Regulatory Factor-7 Synergizes with Other Transcription Factors through Multiple Interactions with p300/CBP Coactivators

2003 • 60 citations

Direct and Indirect Regulation of Cytokine and Cell Cycle Proteins by EBNA-2 during Epstein-Barr Virus Infection

2001 • 58 citations

Introduction of <scp>DNA</scp> into Mammalian Cells

2003 • 56 citations

The Latency-Associated Nuclear Antigen Encoded by Kaposi's Sarcoma-Associated Herpesvirus Activates Two Major Essential Epstein-Barr Virus Latent Promoters

2001 • 51 citations

Preferential binding sites for interferon regulatory factors 3 and 7 involved in interferon-A gene transcription

2002 • 50 citations

B Cell Phenotype-dependent Expression of the Epstein-Barr Virus Nuclear Antigens EBNA-2 to EBNA-6: Studies with Somatic Cell Hybrids

1991 • 48 citations

Domains of the Epstein--Barr virus nuclear antigen 2 (EBNA2) involved in the transactivation of the latent membrane protein 1 and the EBNA Cp promoters

1995 • 47 citations

Chemotherapeutic DNA-damaging drugs activate interferon regulatory factor-7 by the mitogen-activated protein kinase kinase-4-cJun NH2-terminal kinase pathway.

2000 • 47 citations

Functional Cooperation of Epstein-Barr Virus Nuclear Antigen 2 and the Survival Motor Neuron Protein in Transactivation of the Viral LMP1 Promoter

2001 • 43 citations

Genetic analysis of the Epstein–Barr virus-coded leader protein EBNA-LP as a co-activator of EBNA2 function

2001 • 42 citations

Multiple Carboxyl-Terminal Regions of the EBV Oncoprotein, Latent Membrane Protein 1, Cooperatively Regulate Signaling to B Lymphocytes Via TNF Receptor-Associated Factor (TRAF)-Dependent and TRAF-Independent Mechanisms

2001 • 36 citations

The plaque test for the demonstration of antibodies against the enterobacterial common antigen produced by spleen and lymph node cells.

1967 • 7 citations