A Novel Interferon Regulatory Factor (IRF), IRF-10, Has a Unique Role in Immune Defense and Is Induced by the v-Rel Oncoprotein

Basic local alignment search tool

1990 • 87,358 citations

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1997 • 71,835 citations

The neighbor-joining method: a new method for reconstructing phylogenetic trees.

1987 • 59,130 citations

Initial sequencing and analysis of the human genome

2001 • 23,520 citations

The Sequence of the Human Genome

2001 • 13,500 citations

NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

1998 • 5,178 citations

An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs

1987 • 5,139 citations

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

CELLULAR RESPONSES TO INTERFERON-γ

1997 • 2,885 citations

Multiple sequence alignment with Clustal X

1998 • 2,667 citations

Identification of genes differentially regulated by interferon α, β, or γ using oligonucleotide arrays

1998 • 1,781 citations

Aberrant rel/nfkb genes and activity in human cancer

1999 • 1,127 citations

Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements

1988 • 984 citations

Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes

1989 • 970 citations

Molecular Mimicry of Human Cytokine and Cytokine Response Pathway Genes by KSHV

1996 • 926 citations

Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300

1998 • 812 citations

Identification of DNA sequences required for transcription of the human α1-globin gene in a new SV40 host-vector system

1981 • 624 citations

Interferon regulatory factors: the next generation

1999 • 550 citations

The growing family of interferon regulatory factors

1997 • 480 citations

Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.

1995 • 451 citations

Deletion of IRF-1 , Mapping to Chromosome 5q31.1, in Human Leukemia and Preleukemic Myelodysplasia

1993 • 392 citations

Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins.

1992 • 387 citations

Structure of IRF-1 with bound DNA reveals determinants of interferon regulation

1998 • 385 citations

Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes.

1995 • 382 citations

An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes.

1990 • 368 citations

Molecular cloning and characterization of avian sarcoma virus circular DNA molecules

1980 • 361 citations

Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma

1997 • 351 citations

[33] High-expression vectors with multiple cloning sites for construction of trpE fusion genes: pATH vectors

1991 • 350 citations

Two cell lines from lymphomas of Marek's disease.

1974 • 292 citations

Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system.

1994 • 288 citations

Rel/NF-kappaB/IkappaB proteins and cancer.

1996 • 281 citations

NF-κB to the rescue: RELs, apoptosis and cellular transformation

1999 • 276 citations

Essential Role of Interferon Regulatory Factor 3 in Direct Activation of RANTES Chemokine Transcription

1999 • 273 citations

IRF-7, a New Interferon Regulatory Factor Associated with Epstein-Barr Virus Latency

1997 • 253 citations

Molecular cloning ofLSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE)

1995 • 237 citations

Regulation of RANTES Chemokine Gene Expression Requires Cooperativity Between NF-κB and IFN-Regulatory Factor Transcription Factors

2000 • 215 citations

Cell lines derived from avian lymphomas exhibit two distinct phenotypes

1985 • 213 citations

Functional Analysis of Human Herpesvirus 8-Encoded Viral Interferon Regulatory Factor 1 and Its Association with Cellular Interferon Regulatory Factors and p300

1999 • 211 citations

Role of Rel/NF-κB transcription factors during the outgrowth of the vertebrate limb

1998 • 208 citations

Lack of Interferon Consensus Sequence Binding Protein (ICSBP) Transcripts in Human Myeloid Leukemias

1998 • 207 citations

Multiple mutations contribute to the oncogenicity of the retroviral oncoprotein v-Rel

1999 • 204 citations

The regulation and roles of Rel/NF-κB transcription factors during lymphocyte activation

1998 • 198 citations

Principles of Virology: Molecular Biology, Pathogenesis, and Control

1999 • 195 citations

Rel Induces Interferon Regulatory Factor 4 (IRF-4) Expression in Lymphocytes

2000 • 193 citations

The genomic structure of the murine ICSBP gene reveals the presence of the gamma interferon-responsive element, to which an ISGF3 alpha subunit (or similar) molecule binds.

1993 • 184 citations

Characterization of a Novel Human Herpesvirus 8-Encoded Protein, vIRF-3, That Shows Homology to Viral and Cellular Interferon Regulatory Factors

2000 • 178 citations

Interaction of interferon regulatory factor-1 and nuclear factor κB during activation of inducible nitric oxide synthase transcription

1999 • 164 citations

Inhibition of NF-κB activity results in disruption of the apical ectodermal ridge and aberrant limb morphogenesis

1998 • 164 citations

The interferon system and interferon regulatory factor transcription factors – studies from gene knockout mice

2001 • 162 citations

IFN regulatory factor-1 plays a central role in the regulation of the expression of class I and II MHC genes in vivo.

1997 • 162 citations

Phosphorylation Events Modulate the Ability of Interferon Consensus Sequence Binding Protein to Interact with Interferon Regulatory Factors and to Bind DNA

1997 • 162 citations

Regulation of the Promoter Activity of Interferon Regulatory Factor-7 Gene

2000 • 160 citations

Interferon-regulatory factor 1 is an immediate-early gene under transcriptional regulation by prolactin in Nb2 T cells.

1990 • 159 citations

Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes.

1992 • 153 citations

Interferon Regulatory Factor 1 Is Required for Mouse Gbp Gene Activation by Gamma Interferon

1995 • 140 citations

Protein-Protein and DNA-Protein Interactions Affect the Activity of Lymphoid-Specific IFN Regulatory Factors

1999 • 135 citations

The role of interferon regulatory factors in the interferon system and cell growth control

1998 • 134 citations

The Interferon-Induced Mx Protein of Chickens Lacks Antiviral Activity

1995 • 125 citations

Two Domains of ISGF3γ That Mediate Protein-DNA and Protein-Protein Interactions during Transcription Factor Assembly Contribute to DNA-Binding Specificity

1993 • 124 citations

A Family of Genes Coding for Two Serologically Distinct Chicken Interferons

1996 • 111 citations

The activation of major histocompatibility complex class I genes by interferon regulatory factor-1 (IRF-1)

1992 • 108 citations

A Nonproducer T Lymphoblastoid Cell Line from Marek's Disease Transplantable Tumor (JMV)

1977 • 106 citations

Conserved transactivation domain shared by interferon regulatory factors and Smad morphogens

1999 • 105 citations

An Expressed Sequence Tag Database of T-Cell-Enriched Activated Chicken Splenocytes: Sequence Analysis of 5251 Clones

2000 • 104 citations

Interferon regulatory factor subcellular localization is determined by a bipartite nuclear localization signal in the DNA-binding domain and interaction with cytoplasmic retention factors

2000 • 103 citations

Rel/NF‐κB transcription factors: key mediators of B‐cell activation

2000 • 103 citations

Functional Domain Analysis of Interferon Consensus Sequence Binding Protein (ICSBP) and Its Association with Interferon Regulatory Factors

1995 • 99 citations

Reconstitution of Virus-mediated Expression of Interferon α Genes in Human Fibroblast Cells by Ectopic Interferon Regulatory Factor-7

2000 • 98 citations

Cloning and expression of a chicken c-rel cDNA: unlike p59v-rel, p68c-rel is a cytoplasmic protein in chicken embryo fibroblasts.

1990 • 97 citations

Expression of differentiated functions in cancer cells

1982 • 95 citations

Functional domains of interferon regulatory factor I (IRF-1)

1998 • 92 citations

The Chicken Mx Promoter Contains an ISRE Motif and Confers Interferon Inducibility to a Reporter Gene in Chick and Monkey Cells

1994 • 92 citations

Molecular cloning of a novel interferon regulatory factor in Japanese flounder, Paralichthys olivaceus.

1998 • 81 citations

The Rel family: models for transcriptional regulation and oncogenic transformation

1992 • 80 citations

Cloning of Human Lymphocyte-Specific Interferon Regulatory Factor (hLSIRF/hIRF4) and Mapping of the Gene to 6p23–p25

1996 • 80 citations

Ongoing diversification of the rearranged immunoglobulin light-chain gene in a bursal lymphoma cell line.

1990 • 78 citations

New insights into the roles of ReL/NF-κB transcription factors in immune function, hemopoiesis and human disease

1999 • 74 citations

Sequence of a cDNA coding for human IRF-1

1989 • 74 citations

Two domains of ISGF3 gamma that mediate protein-DNA and protein-protein interactions during transcription factor assembly contribute to DNA-binding specificity.

1993 • 71 citations

Isolation and characterization of three class II MHC genomic clones from the chicken.

1989 • 64 citations

Structure and expression of a chicken MHC class I gene

1990 • 61 citations

clRF-3, a new member of the interferon regulatory factor (IRF) family that is rapidly and transiently induced by dsRNA

1995 • 56 citations

Recombinant Chicken Interferon from Escherichia coli and Transfected COS Cells is Biologically Active

1995 • 56 citations

Recombinant Marek’s Disease Virus (MDV)-Derived Lymphoblastoid Cell Lines: Regulation of a Marker Gene within the Context of the MDV Genome

1999 • 55 citations

v-rel induces expression of three avian immunoregulatory surface receptors more efficiently than c-rel

1994 • 50 citations

Quantitative Immunocytochemical Assay for Infectious Avian Retroviruses

1987 • 45 citations

In vivo evolution of c-rel oncogenic potential

1994 • 45 citations

Mutation analysis of the Pip interaction domain reveals critical residues for protein–protein interactions

1999 • 44 citations

Chicken Guanylate-binding Protein

1996 • 42 citations

Inhibition of jun transformation by a mutated fos gene: design of an anti-oncogene.

1991 • 42 citations

Sequence of a cDNA coding for human IRF-2

1989 • 40 citations

Chicken interferon consensus sequence-binding protein (ICSBP) and interferon regulatory factor (IRF) 1 genes reveal evolutionary conservation in the IRF gene family.

1995 • 36 citations

AP-1 Factors Play an Important Role in Transformation Induced by the v-rel Oncogene

1998 • 36 citations

Molecular Cloning and Genomic Structure of a Gene Encoding Interferon Regulatory Factor in the Pufferfish (Fugu rubripes)

2001 • 35 citations

Interferon Regulatory Factor 4 Contributes to Transformation of v-Rel-Expressing Fibroblasts

2001 • 35 citations

Evolution of the oncogenic potential of v-rel: rel-induced expression of immunoregulatory receptors correlates with tumor development and in vitro transformation

1994 • 33 citations

Differences in κB DNA-binding properties of v-Rel and c-Rel are the result of oncogenic mutations in three distinct functional regions of the Rel protein

1997 • 30 citations

Identification of a Novel Cytokine Response Element in the Human IFN Regulatory Factor-1 Gene Promoter

2000 • 27 citations

Mutations in the rel-homology domain alter the biochemical properties of v-rel and render it transformation defective in chicken embryo fibroblasts.

1992 • 26 citations

An interferon regulatory factor-related gene (xIRF-6) is expressed in the posterior mesoderm during the early development of Xenopus laevis

1997 • 24 citations

Functional Evolution of the Myb Oncogene Family

2001 • 22 citations

A mechanism for selective induction of 2′-5′ oligoadenylate synthetase, anti-viral state, but not MHC Class I genes by interferon-beta in neurons

1999 • 21 citations

Impaired class II transactivator expression in mice lacking interferon regulatory factor-2

2001 • 20 citations

Sequence Comparison of Avian Interferon Regulatory Factors and Identification of the Avian CEC-32 Cell as a Quail Cell Line

2000 • 19 citations

Structural Genes, Not the LTRs, Are the Primary Determinants of Reticuloendotheliosis Virus A-Induced Runting and Bursal Atrophy

1994 • 19 citations

Interferon regulatory factor-2 point mutations in human pancreatic tumors

2000 • 17 citations

Immune abnormalities in avian erythroblastosis virus-infected chickens.

1990 • 16 citations

Overexpression of chicken interferon regulatory factor-1 (Ch-IRF-1) induces constitutive expression of MHC class I antigens but does not confer virus resistance to a permanent chicken fibroblast cell line

1998 • 15 citations

Cloning and Promoter Analysis of the Chicken Interferon Regulatory Factor-3 Gene

2000 • 12 citations

The genomic structure of the chicken ICSBP gene and its transcriptional regulation by chicken interferon

1998 • 12 citations

Cloning of Chicken Interferon Regulatory Factor-2 (IRF-2) cDNA: Expression and Mapping of the IRF-2 Gene

1997 • 7 citations

Structure of Mouse Interferon Stimulated Gene Factor 3 (ISGF3 / p48) cDNA and Chromosomal Localization of the Gene

1996 • 5 citations

RETICULOENDOTHELIOSIS VIRUSES (RETROVIRIDAE)

1999 • 3 citations