Mucosal immunity to infection with implications for vaccine development

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Direct Gene Transfer into Mouse Muscle in Vivo

1990 • 3,985 citations

Heterologous Protection Against Influenza by Injection of DNA Encoding a Viral Protein

1993 • 2,330 citations

New use of BCG for recombinant vaccines

1991 • 1,463 citations

DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations.

1993 • 1,122 citations

Immunoglobulin A (IgA): Molecular and Cellular Interactions Involved in IgA Biosynthesis and Immune Response

1987 • 956 citations

The mucosal immune system: from fundamental concepts to vaccine development

1992 • 912 citations

Structure and function of cholera toxin and the related Escherichia coli heat-labile enterotoxin

1992 • 810 citations

Expression of hepatitis B surface antigen in transgenic plants.

1992 • 711 citations

Controlled vaccine release in the gut-associated lymphoid tissues. I. Orally administered biodegradable microspheres target the peyer's patches

1990 • 691 citations

Selection of Bacterial Virulence Genes That Are Specifically Induced in Host Tissues

1993 • 671 citations

Nonreplicating vaccinia vector efficiently expresses recombinant genes.

1992 • 598 citations

Immunological adjuvants: a role for liposomes

1990 • 468 citations

Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues.

1993 • 457 citations

Salmonella typhimurium deletion mutants lacking adenylate cyclase and cyclic AMP receptor protein are avirulent and immunogenic

1987 • 434 citations

Systemic tolerance and secretory immunity after oral immunization.

1980 • 432 citations

Structure and function of cholera toxin and the related Escherichia coli heat-labile enterotoxin.

1992 • 369 citations

Monoclonal secretory immunoglobulin A protects mice against oral challenge with the invasive pathogen Salmonella typhimurium

1992 • 343 citations

Passive transfer of local immunity to influenza virus infection by IgA antibody.

1991 • 322 citations

Humoral and cell-mediated immune responses to live recombinant BCG–HIV vaccines

1991 • 315 citations

Role of Cytokines in the Differentiation of CD4⁺ T‐Cell Subsets in vivo

1991 • 289 citations

Distribution of Poliovirus Antibody in Serum, Nasopharynx and Alimentary Tract Following Segmental Immunization of Lower Alimentary Tract with Poliovaccine

1969 • 272 citations

Protective immunity elicited by recombinant bacille Calmette-Guerin (BCG) expressing outer surface protein A (OspA) lipoprotein: a candidate Lyme disease vaccine.

1993 • 269 citations

Protection Against Vaginal SIV Transmission with Microencapsulated Vaccine

1993 • 265 citations

New model for analysis of mucosal immunity: intestinal secretion of specific monoclonal immunoglobulin A from hybridoma tumors protects against Vibrio cholerae infection

1991 • 257 citations

Oral administration of a streptococcal antigen coupled to cholera toxin B subunit evokes strong antibody responses in salivary glands and extramucosal tissues

1989 • 252 citations

Immunology of breast milk.

1979 • 249 citations

Use of the nirB Promoter to Direct the Stable Expression of Heterologous Antigens in Salmonella Oral Vaccine Strains: Development of a Single–Dose Oral Tetanus Vaccine

1992 • 233 citations

Immunoglobulin A mediation of murine nasal anti-influenza virus immunity

1991 • 229 citations

Optimizing oral vaccines: induction of systemic and mucosal B-cell and antibody responses to tetanus toxoid by use of cholera toxin as an adjuvant

1993 • 208 citations

Expression of rotavirus VP2 produces empty corelike particles

1991 • 199 citations

Mechanism of action of cholera toxin

1980 • 199 citations

A mouse T cell product that preferentially enhances IgA production. I. Biologic characterization.

1987 • 196 citations

Construction of genetically defined double aro mutants of Salmonella typhi

1991 • 191 citations

Oral Salmonella typhimurium (AroA-) vaccine expressing a major leishmanial surface protein (gp63) preferentially induces T helper 1 cells and protective immunity against leishmaniasis.

1990 • 188 citations

Immune-stimulating complexes containing Quil A and protein antigen prime class I MHC-restricted T lymphocytes in vivo and are immunogenic by the oral route.

1991 • 174 citations

The expression of hybrid HIV:Ty virus-like particles in yeast

1987 • 163 citations

Novel Delivery Systems for Oral Vaccines

1994 • 155 citations

Induction of Mucosal and Systemic Immunity to a Recombinant Simian Immunodeficiency Viral Protein

1992 • 142 citations

Vaccine-Containing Biodegradable Microspheres Specifically Enter the Gut-Associated Lymphoid Tissue Following Oral Administration and Induce a Disseminated Mucosal Immune Response

1989 • 132 citations

Comparison of intranasal inoculation of influenza HA vaccine combined with cholera toxin B subunit with oral or parenteral vaccination

1990 • 124 citations

Recombinant human respiratory syncytial virus (RSV)monoclonal antibody Fab is effective therapeutically when introduced directlyinto the lungs of RSV-infected mice.

1994 • 122 citations

The in vitro production of cytokines by mucosal lymphocytes immunized by oral administration of keyhole limpet hemocyanin using cholera toxin as an adjuvant

1991 • 120 citations

Oral vaccination of mice against tetanus by use of a live attenuated Salmonella carrier

1990 • 113 citations

T Lymphocytes in Genital Lymph Nodes Protect Mice from Intravaginal Infection with Herpes Simplex Virus Type 2

1989 • 93 citations

Mucosal and systemic antiviral antibodies in mice inoculated intravaginally with herpes simplex virus type 2

1990 • 92 citations

Safety and immunogenicity in North Americans of a single dose of live oral cholera vaccine CVD 103-HgR: results of a randomized, placebo-controlled, double-blind crossover trial

1992 • 90 citations

Construction of a genetically defined Salmonella typhi Ty2 aroA, aroC mutant for the engineering of a candidate oral typhoid-tetanus vaccine

1992 • 81 citations

Oral immunization with Toxoplasma gondii antigens in association with cholera toxin induces enhanced protective and cell-mediated immunity in C57BL/6 mice

1993 • 80 citations

Comparative effectiveness of the cholera toxin B subunit and alkaline phosphatase as carriers for oral vaccines

1993 • 79 citations

Hepatitis B virus nucleocapsid/pre-S2 fusion proteins expressed in attenuated Salmonella for oral vaccination.

1990 • 76 citations

Immunobiology of the Tonsils and Adenoids

2015 • 74 citations

Safety and immunogenicity of Salmonella typhi Ty21a vaccine in young Thai children

1993 • 73 citations

Oral immunization with recombinant BCG induces cellular and humoral immune responses against the foreign antigen

1993 • 73 citations

The iscom structure as an immune-enhancing moiety: experience with viral systems

1992 • 72 citations

Cholera toxin B-subunit gene fusion: structural and functional analysis of the chimeric protein

1990 • 70 citations

Stabilization of recombinant avirulent vaccine strains in vivo

1990 • 68 citations

Immunogenicity of Recombinant Human Adenovirus-Human Immunodeficiency Virus Vaccines in Chimpanzees

1993 • 58 citations

Encapsidation of genetically engineered poliovirus minireplicons which express human immunodeficiency virus type 1 Gag and Pol proteins upon infection

1993 • 56 citations

Escherichia coli heat-labile toxin subunit B fusions with Streptococcus sobrinus antigens expressed by Salmonella typhimurium oral vaccine strains: importance of the linker for antigenicity and biological activities of the hybrid proteins

1993 • 49 citations

Characterization of poliovirus-specific T lymphocytes in the peripheral blood of Sabin-vaccinated humans

1993 • 39 citations

Amplification of the secretory IgA response toToxoplasma gondiiusing cholera toxin

1991 • 32 citations

Enhancement of systemic and mucosal immune responses following oral administration of liposomes

1993 • 28 citations

Efficacy of oral administration of live herpes simplex virus type 1 as a vaccine

1992 • 21 citations

Vaccines against enterotoxigenic bacterial pathogens based on hybrid salmonella that express heterologous antigens

1990 • 18 citations

Immunobiology of the Tonsils and Adenoids

1994 • 14 citations

Naked DNA and vaccine design

1993 • 6 citations