N-terminal truncated human RAG1 proteins can direct T-cell receptor but not immunoglobulin gene rearrangements

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RAG-1-deficient mice have no mature B and T lymphocytes

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RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

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The V(D)J recombination activating gene, RAG-1

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Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps

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Human T-cell receptor variable gene segment families

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RAG Mutations in Human B Cell-Negative SCID

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IMGT, the international ImMunoGeneTics database

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The RAG1 and RAG2 Proteins Establish the 12/23 Rule in V(D)J Recombination

1996 • 281 citations

Flow cytometric analysis of normal B cell differentiation: a frame of reference for the detection of minimal residual disease in precursor-B-ALL

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Two Pairs of Recombination Signals Are Sufficient to Cause Immunoglobulin V-(D)-J Joining

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Analysis of immunoglobulin and T cell receptor genes. Part II: Possibilities and limitations in the diagnosis and management of lymphoproliferative diseases and related disorders

1991 • 218 citations

Heteroduplex PCR analysis of rearranged T cell receptor genes for clonality assessment in suspect T cell proliferations

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Expression and V(D)J recombination activity of mutated RAG-1 proteins

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Flow cytometric analysis of the V? repertoire in healthy controls

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Cross-lineage T cell receptor gene rearrangements occur in more than ninety percent of childhood precursor-B acute lymphoblastic leukemias: alternative PCR targets for detection of minimal residual disease

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Expression and V(D)J recombination activity of mutated RAG-1 proteins

1993 • 162 citations

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Primary Immunodeficiency Diseases: A Molecular and Genetic Approach

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Ig Heavy Chain Gene Rearrangements in T-Cell Acute Lymphoblastic Leukemia Exhibit Predominant Dh6-19 and Dh7-27 Gene Usage, Can Result in Complete V-D-J Rearrangements, and Are Rare in T-Cell Receptor β Lineage

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CD30 cell expression and abnormal soluble CD30 serum accumulation in Omenn's syndrome: Evidence for a T helper 2‐mediated condition

1996 • 110 citations

T helper type 2‐like cells and therapeutic effects of interferon‐γ in combined immunodeficiency with hypereosinophilia (Omenn's syndrome)

1993 • 92 citations

Dual role of RAG2 in V(D)J recombination: catalysis and regulation of ordered Ig gene assembly

1998 • 86 citations

Intrathymic Restriction and Peripheral Expansion of the T-Cell Repertoire in Omenn Syndrome

1999 • 84 citations

Complementation of V(D)J Recombination Deficiency in RAG-1−/− B Cells Reveals a Requirement for Novel Elements in the N-Terminus of RAG-1

1997 • 79 citations

Roles of the “Dispensable” Portions of RAG-1 and RAG-2 in V(D)J Recombination

1999 • 76 citations

Heterogeneity in junctional regions of immunoglobulin kappa deleting element rearrangements in B cell leukemias: a new molecular target for detection of minimal residual disease

1997 • 75 citations

RAG-1 mutations that affect the target specificity of V(D)j recombination: a possible direct role of RAG-1 in site recognition.

1995 • 70 citations

T-Cell Receptor Analysis in Omenn’s Syndrome: Evidence for Defects in Gene Rearrangement and Assembly

1999 • 62 citations

T CELL SUBSETS AND CYTOKINES IN ALLERGIC AND NON-ALLERGIC CHILDREN. II. ANALYSIS OF IL-5 AND IL-10 mRNA EXPRESSION AND PROTEIN PRODUCTION

1997 • 59 citations

A Basic Motif in the N-Terminal Region of RAG1 Enhances V(D)J Recombination Activity

1997 • 59 citations

Regions of RAG1 protein critical for V(D)J recombination

1996 • 59 citations

RAG and RAG defects

1999 • 57 citations

Specificity in V(D)J recombination: new lessons from biochemistry and genetics

1997 • 40 citations

Differentiation of materno-fetal GVHD from Omenn's syndrome in pre-BMT patients with severe combined immunodeficiency.

1994 • 35 citations

Unravelling human T-cell receptor junctional region sequences.

1994 • 24 citations

Splicing of the platelet‐derived‐growth‐factor A‐chain mRNA in human malignant mesothelioma cell lines and regulation of its expression

1992 • 17 citations

Engrafted maternal T cells in human severe combined immunodeficiency: Evidence for a T H2 phenotype and a potential role of apoptosis on the restriction of T-cell receptor variable β repertoire

1998 • 11 citations

Deleted Work

1955 • 0 citations