Short-Term Breast Cancer Prediction by Random Periareolar Fine-Needle Aspiration Cytology and the Gail Risk Model

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1987 • 11,429 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Tamoxifen for Prevention of Breast Cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study

1998 • 5,487 citations

Projecting Individualized Probabilities of Developing Breast Cancer for White Females Who Are Being Examined Annually

1989 • 3,239 citations

Prognostic and predictive factors in breast cancer by immunohistochemical analysis.

1998 • 2,121 citations

Circulating concentrations of insulin-like growth factor I and risk of breast cancer

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Diseases of the Breast

1971 • 1,803 citations

Efficacy of Bilateral Prophylactic Mastectomy in Women with a Family History of Breast Cancer

1999 • 1,404 citations

Clinical Implications of the p53 Tumor-Suppressor Gene

1993 • 1,341 citations

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1998 • 1,248 citations

Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form.

1990 • 978 citations

Mammographic Features and Breast Cancer Risk: Effects With Time, Age, and Menopause Status

1995 • 860 citations

Mammographic densities and breast cancer risk.

1998 • 804 citations

Association of p53 Protein Expression With Tumor Cell Proliferation Rate and Clinical Outcome in Node-Negative Breast Cancer

1993 • 777 citations

An Atlas of Subgross Pathology of the Human Breast With Special Reference to Possible Precancerous Lesions<xref ref-type="fn" rid="fn2">2</xref>

1975 • 761 citations

Accumulation of p53 Tumor Suppressor Gene Protein: An Independent Marker of Prognosis in Breast Cancers

1992 • 757 citations

Validation Studies for Models Projecting the Risk of Invasive and Total Breast Cancer Incidence

1999 • 743 citations

Breast Cancer Risk After Bilateral Prophylactic Oophorectomy in BRCA1 Mutation Carriers

1999 • 674 citations

Expression of the HER-2/neu proto-oncogene in normal human adult and fetal tissues.

1990 • 640 citations

Dissociation between steroid receptor expression and cell proliferation in the human breast.

1997 • 623 citations

Insulin-like growth factors and cancer

1992 • 622 citations

Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.

1994 • 620 citations

Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion.

1992 • 587 citations

Isolation of the NeuHER-2 stimulatory ligand: A 44 kd glycoprotein that induces differentiation of mammary tumor cells

1992 • 534 citations

Lobular neoplasia of the breast: Higher risk for subsequent invasive cancer predicted by more extensive disease

1991 • 429 citations

Overexpression of HER-2/neu and its relationship with other prognostic factors change during the progression of in situ to invasive breast cancer

1992 • 415 citations

Breast cancer and atypia among young and middle-aged women: a study of 110 medicolegal autopsies

1987 • 411 citations

Elevated Serum Estradiol and Testosterone Concentrations Are Associated with a High Risk for Breast Cancer

1999 • 409 citations

A comparison of the results of long-term follow-up for atypical intraductal hyperplasia and intraductal hyperplasia of the breast

1990 • 374 citations

Combined histologic and cytologic criteria for the diagnosis of mammary atypical ductal hyperplasia

1992 • 373 citations

Patterns of expression of the p53 tumour suppressor in human breast tissues and tumours in situ and in vitro

1990 • 283 citations

Estrogen Receptor Expression in Benign Breast Epithelium and Breast Cancer Risk

1998 • 253 citations

Mammographic Parenchymal Patterns: A Marker of Breast Cancer Risk

1993 • 251 citations

Risk of breast cancer associated with atypical hyperplasia of lobular and ductal types.

1997 • 246 citations

Validation of the Gail et al. Model for Predicting Individual Breast Cancer Risk

1994 • 236 citations

Anatomic markers of human premalignancy and risk of breast cancer

1990 • 219 citations

Nipple aspirate fluid: a promising non-invasive method to identify cellular markers of breast cancer risk

1997 • 186 citations

Validation of a Breast Cancer Risk Assessment Model in Women With a Positive Family History

1994 • 177 citations

Mechanistic considerations in chemopreventive drug development

1994 • 176 citations

Risk biomarkers and current strategies for cancer chemoprevention

1996 • 162 citations

Constitutive expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor abrogates all requirements for exogenous growth factors.

1992 • 159 citations

p53 protein expression in mammary ductal carcinoma in situ: Relationship to immunohistochemical expression of estrogen receptor and c-erbB-2 protein

1993 • 157 citations

Prospective evaluation of radiologically directed fine-needle aspiration biopsy of nonpalpable breast lesions

1990 • 144 citations

Cellular oxidative stress and the control of apoptosis by wild-type p53, cytotoxic compounds, and cytokines.

1996 • 137 citations

p53 and c-erbB-2 Protein Expression in Breast Carcinomas: An Immunohistochemical Study Including Correlations with Receptor Status, Proliferation Markers, and Clinical Stage in Human Breast Cancer

1992 • 126 citations

c-myc, c-erbB-2, and Ki-67 expression in normal breast tissue and in invasive and noninvasive breast carcinoma.

1992 • 123 citations

Differentiation of cultured human breast cancer cells (AU‐565 and MCF‐7) associated with loss of cell surface HER‐2/neu antigen

1990 • 115 citations

p53 protein accumulation detected by five different antibodies: relationship to prognosis and heat shock protein 70 in breast cancer.

1994 • 113 citations

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1991 • 112 citations

Frequency of benign and malignant breast lesions in 207 consecutive autopsies in Australian women

1985 • 109 citations

The subcellular localization of the neu protein in human normal and neoplastic cells

1989 • 108 citations

Immunohistochemical Detection of c-erbB-2 and p53 in Benign Breast Disease and Breast Cancer Risk

1998 • 108 citations

Models for Discrete Data

1999 • 105 citations

Expression of epidermal growth factor receptor mRNA and protein in primary breast carcinomas

1999 • 105 citations

Breast cancer trends Incidence, mortality, and survival

1994 • 99 citations

Chromosomal aneuploidy in proliferative breast disease

1994 • 98 citations

Estrogen and progesterone receptor content in breast epithelial cells from healthy women during the menstrual cycle

1993 • 95 citations

Differential expression of estrogen, progesterone, and epidermal growth factor receptors in normal, benign, and malignant human breast tissues using dual staining immunohistochemistry.

1994 • 91 citations

Mammographic densities and the prevalence and incidence of histological types of benign breast disease

2000 • 88 citations

p53 mutations in benign breast tissue.

1995 • 78 citations

Nuclear Exclusion of Wild-Type p53 in Immortalized Human Retinoblastoma Cells

1997 • 75 citations

Specificity of seven monoclonal antibodies against p53 evaluated with Western blotting, immunohistochemistry, confocal laser scanning microscopy, and flow cytometry.

1997 • 74 citations

neu oncogene protein and epidermal growth factor receptor are independently expressed in benign and malignant breast tissues

1990 • 71 citations

p53 mutations in mammary ductal carcinoma in situ but not in epithelial hyperplasias.

1998 • 66 citations

Cellular accumulation of p53 protein: an independent prognostic factor in stage II breast cancer

1994 • 65 citations

Surface expression of erbB-2 protein is post-transcriptionally regulated in mammary epithelial cells by epidermal growth factor and by the culture density.

1992 • 64 citations

Hormone-dependent cancer

1996 • 61 citations

Breast Cancer Risk Associated with Abnormal Cytology in Nipple Aspirates of Breast Fluid and Prior History of Breast Biopsy

1993 • 60 citations

Immunohistochemical studies of early breast cancer evolution

1994 • 60 citations

Intraepithelial neoplasia, surrogate endpoint biomarkers, and cancer chemoprevention

1993 • 60 citations

Specificity of seven monoclonal antibodies against p53 evaluated with Western blotting, immunohistochemistry, confocal laser scanning microscopy, and flow cytometry

1997 • 58 citations

Cytological evaluation of biological prognostic markers from primary breast carcinomas

1997 • 57 citations

p53 protein expression and nuclear DNA content in breast intraductal proliferations

1995 • 54 citations

Influence of treatment with tamoxifen and change in tumor burden on the IGF-system in breast cancer patients

1996 • 52 citations

Differential expression of cellular oncogenes in benign and malignant human breast tissue

1986 • 50 citations

Mutations in p53 are frequent in the preneoplastic stage of mouse mammary tumor development.

1993 • 49 citations

MODELS FOR EARLY CHEMOPREVENTION TRIALS IN BREAST CANCER

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Cellular adhesion regulates p53 protein levels in primary human keratinocytes.

1997 • 45 citations

Atypia in breast fine-needle aspiration smears correlates poorly with the presence of a prognostically significant proliferative lesion of ductal epithelium

1993 • 45 citations

Cytologic Identification of Clinically Occult Proliferative Breast Disease in Women with a Family History of Breast Cancer

1991 • 44 citations

Cytoplasmic staining of c-erbB-2 is not associated with the presence of detectable c-erbB-2 mRNA in breast cancer specimens

1998 • 41 citations

Image cytometric classification of premalignant breast disease in fine needle aspirates

1988 • 41 citations

p53 quantitative immunocytochemical analysis in breast carcinomas*1

1995 • 39 citations

Relationships between steroid receptor and epithelial cell proliferation in benign fibrocystic disease of the breast

1982 • 39 citations

Morphofunctional Features of Intraductal Hyperplasia, Atypical Intraductal Hyperplasia, and Various Grades of Intraductal Carcinoma

1995 • 38 citations

Cytology Patterns in Random Aspirates from Women at High and Low Risk for Breast Cancer

1995 • 38 citations

Indicators of increased breast cancer risk in humans

1992 • 38 citations

Identification of a chemoprevention cohort from a population of women at high risk for breast cancer

1996 • 36 citations

Evaluation of biomarkers in breast and prostate cancer.

1994 • 32 citations

Biomarker and cytologic abnormalities in women at high and low risk for breast cancer

1993 • 31 citations

Prevalence of aneuploidy, overexpressed ER, and overexpressed EGFR in random breast aspirates of women at high and low risk for breast cancer

1994 • 30 citations

Expression of the c-erbB-2 proto-oncogene product and nuclear DNA content in benign and malignant human breast parenchyma

1992 • 29 citations

Breast cytology and biomarkers obtained by random fine needle aspiration: Use in risk assessment and early chemoprevention trials

1997 • 29 citations

Quantitative determination of c-erbB-2 in human breast tumours: potential prognostic significance of low values

1998 • 27 citations

Reduced testosterone, 17β-oestradiol and sexual hormone binding globulin, and increased insulin-like growth factor-1 concentrations, in healthy nulligravid women aged 19-25 years who were first and/or second degree relatives to breast cancer patients

1997 • 25 citations

Prognostic Biomarkers in Breast Cancer: Factors Affecting Immunohistochemical Evaluation

1995 • 25 citations

Benign breast disease: indicators of increased breast cancer risk.

1992 • 25 citations

Immunocytochemical assay for oestrogen receptor in fine needle aspirates of breast cancer by video image analysis

1989 • 24 citations

Statistical validation of intermediate markers of precancer for use as endpoints in chemoprevention trials

1992 • 19 citations

CLONAL CHROMOSOME-ABERRATIONS IN FIBROCYSTIC BREAST DISEASE-ASSOCIATED WITH INCREASED RISK OF CANCER

1994 • 19 citations

Detection of Proliferative Breast Disease Four-Quadrant, Fine-Needle Aspiration

1990 • 17 citations

Random Fine Needle Aspiration of the Breast of Women at Increased Breast Cancer Risk and Standard Risk Controls

1998 • 16 citations

Significance of immunohistochemical c-erbB-2 product localization pattern for prognosis of primary human breast cancer

1994 • 15 citations

Yield of Terminal Duct Lobule Units in Normal Breast Stereotactic Core Biopsy Specimens: Implications for Biomarker Studies

2000 • 15 citations

HER-2/neu oncogene expression, DNA ploidy and proliferation index in breast cancer.

1992 • 14 citations

Immunohistologic Analysis of Estrogen Receptor Expression in Breast Carcinoma Precursor Lesions

1998 • 13 citations

Presence of epidermal growth factor receptor in breast smears of cyst fluids: relationship to electrolyte ratios and pH concentration.

1992 • 13 citations

Quantitation of preinvasive neoplastic progression in animal models of chemical carcinogenesis

1997 • 12 citations

Cytomorphology of Fibrocystic Change, High-Risk, and Premalignant Breast Lesions

1995 • 10 citations

Potential Use of Biomarkers in Breast Cancer Risk Assessment and Chemoprevention Trials

1995 • 10 citations

Specimen mammography-guided fine-needle aspirates of mammographically normal fatty and dense benign tissue: Analysis of cell number and type

1997 • 9 citations

Chemoprevention of Breast Cancer

1997 • 5 citations

Expression of neu Antigen in Normal Lactating and Prepartum Mammary Epithelial Cells

1995 • 5 citations

p53 Immunopositivity and Gene Mutation in a Group of Women at High Risk for Breast Cancer

1998 • 2 citations

Biomarkers of Proliferative Breast Disease

1995 • 2 citations

RESPONSE: Re: Prognostic Importance of Low c-erbB2 Expression in Breast Tumors

1999 • 1 citations