Expression of the c-erbB-2 proto-oncogene product and nuclear DNA content in benign and malignant human breast parenchyma

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

The Molecular Genetics of Cancer

1987 • 1,729 citations

Diagnostic Histopathology of the Breast

1988 • 1,083 citations

Neu-Protein Overexpression in Breast Cancer

1988 • 860 citations

A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma.

1985 • 607 citations

Expression of c-erbB-2 oncoprotein: a prognostic indicator in human breast cancer.

1989 • 592 citations

HER-2/neu amplification predicts poor survival in node-positive breast cancer.

1990 • 456 citations

OVEREXPRESSION OF THE c-erbB-2 ONCOPROTEIN IN HUMAN BREAST CARCINOMAS: IMMUNOHISTOLOGICAL ASSESSMENT CORRELATES WITH GENE AMPLIFICATION

1987 • 409 citations

DNA content and survival in mammary carcinoma.

1980 • 372 citations

Alterations to either c-erbB-2(neu) or c-myc proto-oncogenes in breast carcinomas correlate with poor short-term prognosis.

1987 • 360 citations

How To Use Prognostic Factors in Axillary Node-Negative Breast Cancer Patients

1990 • 323 citations

Direct Interaction of a Ligand for the erb B2 Oncogene Product with the EGF Receptor and p185 ^{erb B2}

1990 • 279 citations

Structure and expression of c‐erbB‐2 and EGF receptor genes in inflammatory and non‐inflammatory breast cancer: Prognostic significance

1989 • 197 citations

Prognostic significance of nuclear DNA content in mammary adenocarcinomas in humans.

1984 • 196 citations

A v-erbB-related protooncogene, c-erb-B-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma

1985 • 195 citations

c-erbB-2 expression in benign and malignant breast disease

1988 • 190 citations

Immunohistochemical demonstration of c-erbB-2 protein in mammary ductal carcinoma in situ

1990 • 163 citations

Overexpression of erbB-2 or EGF receptor proteins present in early stage mammary carcinoma is detected simultaneously in matched primary tumors and regional metastases.

1989 • 160 citations

Prognostic significance of dna measurements in 409 consecutive breast cancer patients

1988 • 148 citations

Immunohistochemical distribution of c‐erbB‐2 in infiltrating and in situ breast cancer

1988 • 130 citations

Amplification, overexpression, and rearrangement of the erbB-2 protooncogene in primary human stomach carcinomas.

1989 • 130 citations

4. The role of the epidermal growth factor receptor and the c-erbB-2 protein in breast cancer

1990 • 130 citations

Immunohistochemical distribution of c‐erbB‐2 in in situ breast carcinoma—a detailed morphological analysis

1990 • 127 citations

Proto-oncogene abnormalities in human breast cancer: c-ERBB-2 amplification does not correlate with recurrence of disease.

1989 • 127 citations

The neu (c-erbB-2) oncogene.

1989 • 120 citations

Predictive value of nuclear DNA content in breast cancer in relation to clinical and morphologic factors. A retrospective study of 227 consecutive cases

1988 • 117 citations

c-erbB-2 amplification in node-negative human breast cancer.

1989 • 117 citations

Expression pattern of the neu (NGL) gene-encoded growth factor receptor protein (p185neu) in normal and transformed epithelial tissues of the digestive tract.

1989 • 112 citations

NCL‐CB11, a new monoclonal antibody recognizing the internal domain of the c‐erbB‐2 oncogene protein effective for use on formalin‐fixed, paraffin‐embedded tissue

1990 • 108 citations

c‐erbB‐2 oncogene product staining in gastric adenocarcinoma. An immunohistochemical study

1989 • 97 citations

Lack of evidence for the prognostic significance of c-erbB-2 amplification in human breast carcinoma.

1988 • 97 citations

The significance of oncogene amplification in primary breast cancer

1989 • 94 citations

Immunohistochemical detection of the neu protein in tissue sections of human breast tumors with amplified neu DNA.

1988 • 92 citations

Studies of the HER-2/neu Proto-oncogene in Human Breast Cancer

1990 • 83 citations

neu oncogene protein and epidermal growth factor receptor are independently expressed in benign and malignant breast tissues

1990 • 71 citations

Progression of mammary adenocarcinomas as reflected by nuclear DNA content

1984 • 68 citations

HER-2/neu oncogene expression and proliferation in breast cancers.

1990 • 68 citations

Genetic alterations in primary breast cancer

1989 • 49 citations

Persistance de la synthèse de RNA extranucléolaires dans le foie de rats traités par la lasiocarpine. étude par autoradiographie a haute résolution

1970 • 40 citations

Immunohistochemical c-erbB-2 protooncogene expression and nuclear DNA content in human mammary carcinoma in situ.

1992 • 39 citations

DNA ploidy pattern and amplification of ERBB and ERBB2 genes in human gastric carcinomas

1989 • 28 citations

C-erbB-2 protein and neuroendocrine expression in breast carcinomas.

1991 • 17 citations

Variations in feulgen stainability of epithelial parenchymal cells extracted from paraffin‐embedded salivary gland specimens

1990 • 15 citations

Genomic Alterations in Human Breast Cancer: A Review

1989 • 11 citations

MAMMARY CARCINOMA: COMPARISON OF DNA‐CONTENT IN THE PRIMARY TUMOR AND THE CORRESPONDING AXILLARY LYMPHNODE METASTASES

1986 • 10 citations

Expression of the c-erbB-2 Proto-Oncogene Protein in Human Breast Cancer

1989 • 8 citations

New prognostic indicators in resectable breast cancer (review).

1989 • 6 citations

Oncogene Organisation and Expression: Prediction in Breast Cancer

1989 • 5 citations

Cell Proliferative Indices and DNA Content as Prognostic Factors in Primary Breast Cancer

1989 • 3 citations