Reduced cellular expression and activity of the P129T mutant of human fatty acid amide hydrolase: evidence for a link between defects in the endocannabinoid system and problem drug use

Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor

1992 • 5,504 citations

Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB ₁ Receptor Knockout Mice

1999 • 3,597 citations

Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

1996 • 2,079 citations

Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase

2001 • 1,276 citations

Chemical Characterization of a Family of Brain Lipids That Induce Sleep

1995 • 605 citations

Structural Adaptations in a Membrane Enzyme That Terminates Endocannabinoid Signaling

2002 • 477 citations

Blockade of Effects of Smoked Marijuana by the CB1-Selective Cannabinoid Receptor Antagonist SR141716

2001 • 474 citations

The endocannabinoid system: a general view and latest additions

2004 • 460 citations

A cannabinoid mechanism in relapse to cocaine seeking

2001 • 434 citations

Molecular characterization of human and mouse fatty acid amide hydrolases

1997 • 426 citations

Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness

2002 • 344 citations

A missense mutation in human fatty acid amide hydrolase associated with problem drug use

2002 • 342 citations

Mice lacking fatty acid amide hydrolase exhibit a cannabinoid receptor-mediated phenotypic hypoalgesia

2004 • 295 citations

The Palmitoylethanolamide Family: A New Class of Anti-Inflammatory Agents ?

2002 • 290 citations

Direct visualization of serine hydrolase activities in complex proteomes using fluorescent active site-directed probes

2001 • 278 citations

Genes and addiction

2000 • 208 citations

The fatty acid amide hydrolase (FAAH)

2002 • 203 citations

Increased Seizure Susceptibility and Proconvulsant Activity of Anandamide in Mice Lacking Fatty Acid Amide Hydrolase

2003 • 183 citations

Stimulation of voluntary ethanol intake by cannabinoid receptor agonists in ethanol-preferring sP rats

2001 • 172 citations

Regulated Co-translational Ubiquitination of Apolipoprotein B100

1998 • 154 citations

Comparative Characterization of a Wild Type and Transmembrane Domain-Deleted Fatty Acid Amide Hydrolase: Identification of the Transmembrane Domain as a Site for Oligomerization

1998 • 148 citations

Cotranslational Ubiquitination of Cystic Fibrosis Transmembrane Conductance Regulator in Vitro

1998 • 132 citations

Chronic treatment with Δ9-tetrahydrocannabinol enhances the locomotor response to amphetamine and heroin. Implications for vulnerability to drug addiction

2001 • 116 citations

The enzymatic inactivation of the fatty acid amide class of signaling lipids

2002 • 115 citations

Endoplasmic Reticulum‐Localized Amyloid β‐Peptide is Degraded in the Cytosol by Two Distinct Degradation Pathways

2003 • 72 citations

Endocannabinoids and their actions

2002 • 69 citations

Temperature-sensitive ZAP70 Mutants Degrading through a Proteasome-independent Pathway

1999 • 61 citations

Mutant Products of the NF2 Tumor Suppressor Gene Are Degraded by the Ubiquitin-Proteasome Pathway

2002 • 33 citations

A Transcriptionally Inactive E2F-1 Targets the MDM Family of Proteins for Proteolytic Degradation

2001 • 17 citations