Mice lacking fatty acid amide hydrolase exhibit a cannabinoid receptor-mediated phenotypic hypoalgesia

Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor

1992 • 5,504 citations

A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

1988 • 4,963 citations

Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB ₁ Receptor Knockout Mice

1999 • 3,597 citations

Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors

1995 • 2,837 citations

2-Arachidonoylgylcerol: A Possible Endogenous Cannabinoid Receptor Ligand in Brain

1995 • 2,122 citations

Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

1996 • 2,079 citations

SR141716A, a potent and selective antagonist of the brain cannabinoid receptor

1994 • 1,743 citations

Leptin-regulated endocannabinoids are involved in maintaining food intake

2001 • 1,557 citations

Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase

2001 • 1,276 citations

Modulation of anxiety through blockade of anandamide hydrolysis

2002 • 1,251 citations

Control of pain initiation by endogenous cannabinoids

1998 • 1,044 citations

2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB ₁ receptor

2001 • 752 citations

Preserved Acute Pain and Reduced Neuropathic Pain in Mice Lacking PKCγ

1997 • 685 citations

An anorexic lipid mediator regulated by feeding

2001 • 685 citations

SR 144528, the first potent and selective antagonist of the CB2 cannabinoid receptor.

1998 • 679 citations

Chemical Characterization of a Family of Brain Lipids That Induce Sleep

1995 • 605 citations

Characterization of a Novel Endocannabinoid, Virodhamine, with Antagonist Activity at the CB1 Receptor

2002 • 601 citations

Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors

1998 • 496 citations

Pain modulation by release of the endogenous cannabinoid anandamide

1999 • 482 citations

Pharmacological activity of the cannabinoid receptor agonist, anandamide, a brain constituent

1993 • 453 citations

Partial sciatic nerve injury in the mouse as a model of neuropathic pain: behavioral and neuroanatomical correlates

1998 • 432 citations

The pharmacological activity of anandamide, a putative endogenous cannabinoid, in mice.

1994 • 383 citations

The role of central and peripheral Cannabinoid1 receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain

2001 • 369 citations

The anti-hyperalgesic actions of the cannabinoid anandamide and the putative CB2 receptor agonist palmitoylethanolamide in visceral and somatic inflammatory pain

1998 • 351 citations

N-(2-Hydroxyethyl)hexadecanamide is orally active in reducing edema formation and inflammatory hyperalgesia by down-modulating mast cell activation

1996 • 325 citations

The analgesic effects of R(+)-WIN 55,212–2 mesylate, a high affinity cannabinoid agonist, in a rat model of neuropathic pain

1997 • 299 citations

Improvement of memory in rodents by the selective CB1 cannabinoid receptor antagonist, SR 141716

1996 • 287 citations

Antihyperalgesic effects of spinal cannabinoids

1998 • 282 citations

Investigation of brain sites mediating cannabinoid-induced antinociception in rats: evidence supporting periaqueductal gray involvement.

1996 • 255 citations

CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain

2002 • 233 citations

Pharmacological Activity of Fatty Acid Amides Is Regulated, but Not Mediated, by Fatty Acid Amide Hydrolase in Vivo

2002 • 223 citations

Δ9-Tetrahydrocannabinol impairs spatial memory through a cannabinoid receptor mechanism

1996 • 213 citations

Endocannabinoids and pain: spinal and peripheral analgesia in inflammation and neuropathy

2002 • 186 citations

Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat

2002 • 186 citations

Increased Seizure Susceptibility and Proconvulsant Activity of Anandamide in Mice Lacking Fatty Acid Amide Hydrolase

2003 • 183 citations

Hypoactivity of the Spinal Cannabinoid System Results in NMDA-Dependent Hyperalgesia

1998 • 176 citations

Cannabinoid analgesia

2002 • 173 citations

SR 141716A enhances spatial memory as assessed in a radial-arm maze task in rats

2000 • 169 citations

Spinal and peripheral mechanisms of cannabinoid antinociception: behavioral, neurophysiological and neuroanatomical perspectives

2002 • 160 citations

Characterization of Δ9-Tetrahydrocannabinol and Anandamide Antinociception in Nonarthritic and Arthritic Rats

1998 • 153 citations

Anti-edema and analgesic properties of delta9-tetrahydrocannabinol (THC).

1973 • 115 citations

A cannabinoid agonist differentially attenuates deep tissue hyperalgesia in animal models of cancer and inflammatory muscle pain

2003 • 112 citations

Administration of Endocannabinoids Prevents a Referred Hyperalgesia Associated with Inflammation of the Urinary Bladder

2001 • 107 citations

Two distinctive antinociceptive systems in rats with pathological pain

2000 • 104 citations

The Selective Cannabinoid Antagonist SR 141716A Blocks Cannabinoid-Induced Antinociception in Rats

1997 • 93 citations

Tonic analgesic effects of Δ9-tetrahydrocannabinol as measured with the formalin test

1980 • 50 citations

Structural requirements for cannabinoid-induced antinociceptive activity in mice

1985 • 38 citations

I. Évaluation de la douleur aiguë chez l’animal d’expérience. Première partie

2001 • 35 citations

HU-210 shows higher efficacy and potency than morphine after intrathecal administration in the mouse formalin test

2001 • 31 citations