Genes and addiction

What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?

1998 • 3,973 citations

Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB ₁ Receptor Knockout Mice

1999 • 3,597 citations

Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter

1996 • 2,452 citations

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene

1996 • 1,652 citations

Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies

1997 • 1,362 citations

Molecular and Cellular Basis of Addiction

1997 • 1,324 citations

Measuring reward with the conditioned place preference paradigm: a comprehensive review of drug effects, recent progress and new issues

1998 • 1,247 citations

Neuroscience of Addiction

1998 • 1,030 citations

Enhanced Morphine Analgesia in Mice Lacking β-Arrestin 2

1999 • 1,014 citations

The role of excitatory amino acids in behavioral sensitization to psychomotor stimulants

1998 • 936 citations

Regulation of Cocaine Reward by CREB

1998 • 762 citations

Genome-wide search for genes affecting the risk for alcohol dependence

1998 • 738 citations

Associative Processes in Addiction and Reward The Role of Amygdala‐Ventral Striatal Subsystems

1999 • 713 citations

Co-occurrence of Abuse of Different Drugs in Men

1998 • 713 citations

Stress-induced relapse to heroin and cocaine seeking in rats: a review

2000 • 695 citations

Drug-activation of brain reward pathways

1998 • 679 citations

Expression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine

1999 • 630 citations

Animal Models of Alcoholism: Neurobiology of High Alcohol-Drinking Behavior in Rodents

1998 • 619 citations

Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men.

1991 • 613 citations

Cocaine self-administration in dopamine-transporter knockout mice

1998 • 523 citations

Illicit Psychoactive Substance Use, Heavy Use, Abuse, and Dependence in a US Population-Based Sample of Male Twins

2000 • 502 citations

How many diseases does it take to map a gene with SNPs?

2000 • 492 citations

Ethanol consumption and resistance are inversely related to neuropeptide Y levels

1998 • 477 citations

Absence of opiate rewarding effects in mice lacking dopamine D2 receptors

1997 • 435 citations

Retention of Supraspinal Delta-like Analgesia and Loss of Morphine Tolerance in δ Opioid Receptor Knockout Mice

1999 • 422 citations

Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an american indian population

1998 • 396 citations

Enhancement of Locomotor Activity and Conditioned Reward to Cocaine by Brain-Derived Neurotrophic Factor

1999 • 376 citations

Elevated alcohol consumption in null mutant mice lacking 5–HT1B serotonin receptors

1996 • 356 citations

Neural systems for behavioral activation and reward

1999 • 336 citations

Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor

1998 • 329 citations

Dopamine modulates acute responses to cocaine, nicotine and ethanol in Drosophila

2000 • 315 citations

CREB (cAMP Response Element-Binding Protein) in the Locus Coeruleus: Biochemical, Physiological, and Behavioral Evidence for a Role in Opiate Dependence

1997 • 298 citations

Reduction of Morphine Abstinence in Mice with a Mutation in the Gene Encoding CREB

1996 • 293 citations

A twin-family study of alcoholism in women

1994 • 282 citations

Requirement of Circadian Genes for Cocaine Sensitization in Drosophila

1999 • 259 citations

Identifying genes for alcohol and drug sensitivity: recent progress and future directions

1999 • 259 citations

Rewarding effects of opiates are absent in mice lacking the receptor for substance P

2000 • 215 citations

Quantitative trait loci mapping of three loci controlling morphine preference using inbred mouse strains

1994 • 181 citations

CART peptides: novel addiction- and feeding-related neuropeptides

1999 • 169 citations

Role for GDNF in Biochemical and Behavioral Adaptations to Drugs of Abuse

2000 • 168 citations

The genetics of pain and pain inhibition.

1996 • 152 citations

The trace amine tyramine is essential for sensitization to cocaine in Drosophila

1999 • 149 citations

Nicotine Receptor Inactivation Decreases Sensitivity to Cocaine

2001 • 116 citations

Alcohol Metabolism and Cardiovascular Response in an Alcoholic Patient Homozygous for theALDH2*2Variant Gene Allele

1999 • 113 citations

Induction of cyclin-dependent kinase 5 in the hippocampus by chronic electroconvulsive seizures: role of [Delta]FosB.

2000 • 105 citations

Molecular mechanisms of drug addiction: adaptations in signal transduction pathways.

1996 • 105 citations

Basic concepts in the study of diseases with complex genetics

1999 • 98 citations

Induction of Cyclin-Dependent Kinase 5 in the Hippocampus by Chronic Electroconvulsive Seizures: Role of ΔFosB

2000 • 97 citations

ΔFosB: a molecular switch underlying long-term neural plasticity

2000 • 87 citations

Genetic analysis of behavioral, neuroendocrine, and biochemical parameters in inbred rodents: initial studies in Lewis and Fischer 344 rats and in A/J and C57BL/6J mice

1998 • 62 citations

Molecular genetic analysis of mammalian behavior and brain processes: caveats and perspectives

1996 • 33 citations

Interrupted expression ofNAC-1 augments the behavioral responses to cocaine

1999 • 31 citations