Chemical genomics as an emerging paradigm for postgenomic drug discovery

The druggable genome

2002 • 3,099 citations

Drug Discovery: A Historical Perspective

2000 • 2,654 citations

Discovering High-Affinity Ligands for Proteins: SAR by NMR

1996 • 1,986 citations

High-Density Miniaturized Thermal Shift Assays as a General Strategy for Drug Discovery

2001 • 825 citations

Exploiting Chemical Libraries, Structure, and Genomics in the Search for Kinase Inhibitors

1998 • 792 citations

Chemosensitivity prediction by transcriptional profiling

2001 • 673 citations

Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools

2000 • 564 citations

Chemical genetics resulting from a passion for synthetic organic chemistry

1998 • 405 citations

Profiling Serine Hydrolase Activities in Complex Proteomes

2001 • 361 citations

Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness

2002 • 344 citations

Chemical Approaches for Functionally Probing the Proteome

2002 • 293 citations

PERSPECTIVE

2003 • 245 citations

A chemical genomics approach toward understanding the global functions of the target of rapamycin protein (TOR)

2000 • 171 citations

Chemogenomic approaches to drug discovery

2001 • 166 citations

Chemical genetic approaches for the elucidation of signaling pathways

2001 • 142 citations

Finding the next Gleevec: FLT3 targeted kinase inhibitor therapy for acute myeloid leukemia

2002 • 113 citations

Chemical genomics: Functional analysis of orphan nuclear receptors in the regulation of bile acid metabolism

2001 • 109 citations

Structure-based screening of low-affinity compounds

2002 • 108 citations

Fulfilling the promise: drug discovery in the post-genomic era

2003 • 106 citations

Structural biology in drug design: selective protein kinase inhibitors

2002 • 100 citations

Comparison of Assay Technologies for a Tyrosine Kinase Assay Generates Different Results in High Throughput Screening

2002 • 99 citations

Chemical ligands, genomics and drug discovery

2000 • 89 citations

High-diversity combinatorial libraries

2000 • 89 citations

The chemical-biological interface: developments in automated and miniaturised screening technology

1997 • 81 citations

Novel chemical genetic approaches to the discovery of signal transduction inhibitors

2002 • 81 citations

An Autosampling Differential Scanning Calorimeter Instrument for Studying Molecular Interactions

2002 • 79 citations

Minireview: Genomics Versus Orphan Nuclear Receptors—A Half-Time Report

2002 • 76 citations

Serendipity meets precision: the integration of structure-based drug design and combinatorial chemistry for efficient drug discovery

1997 • 68 citations

High-throughput chemistry and structure-based design: survival of the smartest

2001 • 61 citations

Functional cell-based uHTS in chemical genomic drug discovery

2002 • 56 citations

New drug approvals for 2002

2003 • 51 citations

HTS in the new millennium

2000 • 46 citations

Chemical Genomics: A Systematic Approach in Biological Research and Drug Discovery

2002 • 43 citations

Chemical genomics in the global study of protein functions

2002 • 41 citations

The new partnership of genomics and chemistry for accelerated drug development

1997 • 32 citations

Probes for chemical genomics by design

2002 • 31 citations

Applications of biomolecular interaction analysis in drug development

2002 • 26 citations

Targeting signal transduction with large combinatorial collections

2002 • 15 citations

Special Report: High Throughput Screening 2002: Moving Toward Increased Success Rates

2002 • 15 citations

Chemical genomics: discovery of disease genes and drugs

2002 • 11 citations

Discovery of new chemical classes of synthetic ligands that suppress neuroinflammatory responses

2002 • 8 citations

Chemogenomics – pharmacology with genomics tools

2002 • 6 citations

Finding the molecules to fuel chemogenomics

2002 • 6 citations

Turning quantity into quality: novel quality assurance strategies for data produced by high-throughput genomics technologies

2002 • 3 citations

Deleted Work

1955 • 0 citations