Probes for chemical genomics by design

Genetic algorithms in search, optimization, and machine learning

1989 • 49,726 citations

Initial sequencing and analysis of the human genome

2001 • 23,520 citations

The Sequence of the Human Genome

2001 • 13,500 citations

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

Simulated annealing: theory and applications.

1988 • 3,091 citations

Handbook of Proteolytic Enzymes

2004 • 2,698 citations

Drug Discovery: A Historical Perspective

2000 • 2,654 citations

Functional Discovery via a Compendium of Expression Profiles

2000 • 2,581 citations

Target-Oriented and Diversity-Oriented Organic Synthesis in Drug Discovery

2000 • 2,450 citations

Simulated Annealing: Theory and Applications

1987 • 2,182 citations

A gene expression database for the molecular pharmacology of cancer

2000 • 1,447 citations

FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics.

1987 • 1,216 citations

FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro.

1987 • 1,209 citations

The Handbook of proteolytic enzymes

1998 • 1,123 citations

The PROSITE database, its status in 2002

2002 • 1,010 citations

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

1999 • 970 citations

Human aspartic protease memapsin 2 cleaves the β-secretase site of β-amyloid precursor protein

2000 • 777 citations

Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase

1995 • 520 citations

Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function.

1996 • 504 citations

Small molecule developmental screens reveal the logic and timing of vertebrate development

2000 • 483 citations

Chemical genetics: ligand-based discovery of gene function

2000 • 417 citations

Completeness in structural genomics.

2001 • 347 citations

Structure-based drug design: the discovery of novel nonpeptide orally active inhibitors of human renin

2000 • 310 citations

Molecular Similarity in Drug Design

1995 • 289 citations

Comparative Protein Structure Modeling: Introduction and Practical Examples with Modeller

2003 • 233 citations

From structure to function: approaches and limitations.

2000 • 202 citations

Global Efforts in Structural Genomics

2001 • 196 citations

GroupBuild: a fragment-based method for de novo drug design

1993 • 185 citations

MODBASE, a database of annotated comparative protein structure models

2002 • 179 citations

A chemical genomics approach toward understanding the global functions of the target of rapamycin protein (TOR)

2000 • 171 citations

Databases for Protein–Ligand Complexes

1998 • 110 citations

CONCERTS: Dynamic Connection of Fragments as an Approach to de Novo Ligand Design

1996 • 107 citations

Automated site-directed drug design: a general algorithm for knowledge acquisition about hydrogen-bonding regions at protein surfaces

1989 • 105 citations

Automated site-directed drug design : the formation of molecular templates in primary structure generation

1989 • 70 citations

High-throughput chemistry and structure-based design: survival of the smartest

2001 • 61 citations

Functional cell-based uHTS in chemical genomic drug discovery

2002 • 56 citations

Automated site-directed drug design : the prediction and observation of ligand point positions at hydrogen-bonding regions on protein surfaces

1989 • 51 citations

Virtual Screening: An Alternative or Complement to High Throughput Screening?

2002 • 42 citations

Development of a Pharmacophore Model for Histamine H₃ Receptor Antagonists, Using the Newly Developed Molecular Modeling Program SLATE

2001 • 40 citations

Computational tools for structure-based ligand design

1996 • 33 citations

Chemical genomics: what will it take and who gets to play?

2001 • 29 citations

SLATE: a method for the superposition of flexible ligands.

2001 • 27 citations

Structure-based ligand design by dynamically assembling molecular building blocks at binding site

1999 • 27 citations

The commercial use of structural genomics

2001 • 7 citations