Low Plasma Leptin in Response to Dietary Fat in Diabetes- and Obesity-Prone Mice

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans

1996 • 6,254 citations

Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene

1995 • 4,457 citations

Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice

1995 • 4,057 citations

Identification and expression cloning of a leptin receptor, OB-R

1995 • 3,498 citations

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

1995 • 3,302 citations

Abnormal splicing of the leptin receptor in diabetic mice

1996 • 2,361 citations

Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice

1996 • 2,185 citations

A role for brown adipose tissue in diet-induced thermogenesis

1979 • 1,587 citations

Diet-Induced Type II Diabetes in C57BL/6J Mice

1988 • 1,111 citations

Transient increase in obese gene expression after food intake or insulin administration

1995 • 1,102 citations

Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and mice

1995 • 614 citations

Dietary obesity in nine inbred mouse strains

1992 • 487 citations

Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus.

1995 • 466 citations

Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity.

1995 • 367 citations

Diabetes-Obesity Syndromes in Mice

1982 • 357 citations

Reduced sympathetic nervous activity. A potential mechanism predisposing to body weight gain.

1993 • 296 citations

Expression of ob Gene in Adipose Cells

1996 • 287 citations

Regulation of ob gene mRNA levels in cultured adipocytes

1996 • 268 citations

The beta 3-adrenergic receptor inhibits insulin-stimulated leptin secretion from isolated rat adipocytes.

1996 • 245 citations

Identification of Incidental Sequence Polymorphisms and Absence of the db/db Mouse and fa/fa Rat Mutations

1996 • 225 citations

Molecular cloning of rat obese cDNA and augmented gene expression in genetically obese Zucker fatty (fa/fa) rats.

1995 • 213 citations

Increased proton conductance pathway in brown adipose tissue mitochondria of rats exhibiting diet-induced thermogenesis

1980 • 160 citations

Regional fat distribution and metabolism in a new mouse model () of non-insulin-dependent diabetes mellitus

1993 • 127 citations

Pharmacologic Manipulation of ob Expression in a Dietary Model of Obesity

1996 • 86 citations

Defective Glucose-Stimulated Insulin Release from Perifused Islets of C57BL/6J Mice

1995 • 47 citations

Impaired second phase insulin response of diabetes-prone C57BL/6J mouse islets

1995 • 31 citations