Bcl-2 determines susceptibility to induction of lung cancer by oncogenic CRaf.

Mitochondrial control of cell death

2000 • 3,098 citations

Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras

2001 • 1,824 citations

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1993 • 1,638 citations

Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

2001 • 1,145 citations

Using Antibodies: A Laboratory Manual

1998 • 1,012 citations

Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria

1996 • 785 citations

Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes

2001 • 582 citations

The ins and outs of Raf kinases

1994 • 537 citations

Pharmacological inhibitors of MAPK pathways

2002 • 437 citations

BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death

2000 • 415 citations

Disappearance of the Lymphoid System in Bcl-2 Homozygous Mutant Chimeric Mice

1993 • 402 citations

Ras Activation of the Raf Kinase: Tyrosine Kinase Recruitment of the MAP Kinase Cascade

2001 • 384 citations

Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1.

1996 • 364 citations

Systemic Overexpression of BCL-2 in the Hematopoietic System Protects Transgenic Mice From the Consequences of Lethal Irradiation

1998 • 299 citations

Postnatal growth of the mouse lung.

1977 • 277 citations

Mouse models of cell death

2001 • 270 citations

Inactivation of bcl-2 Results in Progressive Degeneration of Motoneurons, Sympathetic and Sensory Neurons during Early Postnatal Development

1996 • 263 citations

Isotype-Specific Functions of Raf Kinases

1999 • 259 citations

Cell cycle targets of Ras/Raf signalling

1998 • 257 citations

Apoptosis regulation by interaction of Bcl-2 protein and Raf-1 kinase.

1994 • 233 citations

Pulmonary preinvasive neoplasia

2001 • 222 citations

Molecular biology of lung cancer: Clinical implications

2002 • 206 citations

Mouse model for lung tumorigenesis through Cre/lox controlled sporadic activation of the K-Ras oncogene

2001 • 203 citations

Paradoxical inhibition of solid tumor cell growth by bcl2.

1994 • 190 citations

Apoptosis Suppression by Raf-1 and MEK1 Requires MEK- and Phosphatidylinositol 3-Kinase-Dependent Signals

2001 • 181 citations

Raf induces NF-κB by membrane shuttle kinase MEKK1, a signaling pathway critical for transformation

2000 • 174 citations

v-raf suppresses apoptosis and promotes growth of interleukin-3-dependent myeloid cells.

1994 • 111 citations

Specific function of B-Raf in mediating survival of embryonic motoneurons and sensory neurons

2001 • 109 citations

Lung-targeted expression of the c-Raf-1 kinase in transgenic mice exposes a novel oncogenic character of the wild-type protein.

2000 • 106 citations

Expression of Bcl-2 Increases Intracellular Glutathione by Inhibiting Methionine-Dependent GSH Efflux

1998 • 93 citations

Technologically advanced cancer modeling in mice

2002 • 80 citations

Apoptosis and cell division

2000 • 75 citations

Negative regulation of mitochondrial VDAC channels by C-Raf kinase.

2002 • 65 citations

Independent control of cell survival by Raf-1 and Bcl-2 at the mitochondria

2001 • 58 citations

BCL2 expression correlates with metastatic potential in pancreatic cancer cell lines

2001 • 48 citations

Loss of Bcl-2 expression correlates with tumour recurrence in colorectal cancer

1998 • 46 citations

Role of raf oncogenes in lung carcinogenesis

1988 • 32 citations

v-Raf/v-Myc Synergism in Abrogation of IL-3 Dependence: v-Raf Suppresses Apoptosis

1992 • 26 citations

Susceptibility to raf and raf/myc retroviruses is governed by different genetic loci

1989 • 4 citations