Molecular analysis of reactive oxygen‐species‐induced mammalian gene mutation

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia

1985 • 9,128 citations

Biology of disease: free radicals and tissue injury.

1982 • 3,078 citations

DNA Damage and Oxygen Radical Toxicity

1988 • 1,964 citations

Biological effects of the superoxide radical

1986 • 1,446 citations

Deletion screening of the Duchenne muscular dystrophy locus via multiplex DNA amplification

1988 • 1,260 citations

Oxidants and human disease: some new concepts ¹

1987 • 1,171 citations

Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase.

1981 • 1,048 citations

A new Salmonella tester strain (TA102) with A X T base pairs at the site of mutation detects oxidative mutagens.

1982 • 747 citations

Toxic drug effects associated with oxygen metabolism: Redox cycling and lipid peroxidation

1981 • 650 citations

Oxygen-dependent mutagenesis in Escherichia coli lacking superoxide dismutase.

1986 • 314 citations

Identification of mutations leading to the Lesch-Nyhan syndrome by automated direct DNA sequencing of in vitro amplified cDNA.

1989 • 286 citations

Mutagenicity of oxygen free radicals.

1982 • 270 citations

Reduced oxygen species, mutation, induction and cancer initiation

1987 • 267 citations

A quantitative assay of mutation induction at the hypoxanthine-guanine phosphoribosyl transferase locus in Chinese hamster ovary cells (CHO/HGPRT system): Development and definition of the system

1977 • 267 citations

Stimulated Human Phagocytes Produce Cytogenetic Changes in Cultured Mammalian Cells

1983 • 262 citations

Genotoxicity of active oxygen species in mammalian cells

1988 • 244 citations

AN APPROACH TO FREE RADICALS

1983 • 210 citations

The dose-response relationship for ethyl methanesulfonate-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in Chinese hamster ovary cells

1975 • 193 citations

Evidence for reactive oxygen species inducing mutations in mammalian cells.

1986 • 175 citations

A quantitative assay of mutation induction at the hypoxanthine-guanine phosphoribosyl transferase locus in Chinese hamster ovary cells (CHO/HGPRT system): Utilization with a variety of mutagenic agents

1977 • 151 citations

Deletion and amplification of the HGPRT locus in Chinese hamster cells.

1983 • 147 citations

The use of Chinese hamster ovary cells to quantify specific locus mutation and to determine mutagenicity of chemicals

1981 • 141 citations

Specific-locus mutations induced in eukaryotes (especially mammalian cells) by radiation and chemicals: a perspective

1989 • 138 citations

Detection of deletion mutations in pSV2gpt-transformed cells.

1984 • 134 citations

Analyses of mutation in pSV2gpt-transformed CHO cells

1986 • 87 citations

The dose-response relationship for ultraviolet-light-induced mutations at the hypoxanthine-guanine phosphoribosyltransferase locus in Chinese hamster ovary cells

1975 • 87 citations

Genetic damage in CHO cells exposed to enzymically generated active oxygen species

1984 • 84 citations

Quantitative and Molecular Analyses of Radiation-Induced Mutation in AS52 Cells

1986 • 82 citations

Mutagenicity, cytotoxicity, and DNA binding of platinum(II)-chloroammines in Chinese hamster ovary cells.

1980 • 76 citations

Banbury Report 2. Mammalian cell mutagenesis: the maturation of test systems

1982 • 75 citations

Superoxide anion generated by potassium superoxide is cytotoxic and mutagenic to Chinese hamster ovary cells

1983 • 73 citations

Quantitative and molecular analyses of ethyl methanesulfonate- and ICR 191-induced mutation in AS52 cells

1986 • 72 citations

Mammalian cell mutagenesis : the maturation of test systems

1979 • 69 citations

Comparative mutagenicity of alkylsulfate and alkanesulfonate derivatives in chinese hamster ovary cells

1978 • 59 citations

Mutagenicity of heterocyclic nitrogen mustards (ICR compounds) in cultured mammalian cells.

1978 • 49 citations

Mutagenicity and cytotoxicity of congeners of two classes of nitroso compounds in chinese hamster ovary cells

1978 • 43 citations

Theories of carcinogenesis

1990 • 43 citations

A review and analysis of the Chinese hamster ovary/hypoxanthine guanine phosphoribosyl transferase assay to determine the mutagenicity of chemical agents. A report of phase III of the U.S. environmental protection agency Gene-Tox program

1988 • 40 citations

Mutagenicity and cytotoxicity of haloethanes as studied in the CHO/HGPRT system

1981 • 33 citations

Mutagenicity and cytotoxicity of nineteen heterocyclic mustards (ICR compounds) in cultured mammalian cells.

1979 • 31 citations

Further evidence for the genetic origin of mutations in mammalian somatic cells: The effects of ploidy level and selection stringency on dose-dependent chemical mutagenesis to purine analogue resistance in Chinese hamster ovary cells

1977 • 28 citations

Deletion screening at the hypoxanthine‐guanine phosphoribosyltransferase locus in chinese hamster cells using the polymerase chain reaction

1989 • 20 citations

Advances in free radical biology and medicine

1985 • 12 citations