Genotoxicity of active oxygen species in mammalian cells

Oxygen-Derived Free Radicals in Postischemic Tissue Injury

1985 • 5,488 citations

Superoxide Dismutases

1977 • 5,311 citations

Oxygen toxicity, oxygen radicals, transition metals and disease

1984 • 5,301 citations

Dietary Carcinogens and Anticarcinogens

1983 • 3,028 citations

Prooxidant States and Tumor Promotion

1985 • 2,541 citations

The catalytic decomposition of hydrogen peroxide by iron salts

1934 • 2,483 citations

Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts

1986 • 2,052 citations

Free Radical Mechanisms in Tissue Injury

1988 • 1,585 citations

Free-radical mechanisms in tissue injury

1984 • 1,518 citations

Biological effects of the superoxide radical

1986 • 1,446 citations

Iron Transport and Storage Proteins

1980 • 1,183 citations

Free Radicals and Inflammation: Protection of Synovial Fluid by Superoxide Dismutase

1974 • 1,109 citations

Potential Metal-Binding Domains in Nucleic Acid Binding Proteins

1986 • 1,096 citations

Positive control of a regulon for defenses against oxidative stress and some heat-shock proteins in Salmonella typhimurium

1985 • 1,025 citations

The importance of free radicals and catalytic metal ions in human diseases

1985 • 939 citations

The Generation of Hydrogen Peroxide, Superoxide Radical, and Hydroxyl Radical by 6-Hydroxydopamine, Dialuric Acid, and Related Cytotoxic Agents

1974 • 894 citations

Superoxide‐dependent production of hydroxyl radical catalyzed by iron—EDTA complex

1978 • 876 citations

Iron-catalyzed hydroxyl radical formation. Stringent requirement for free iron coordination site.

1984 • 849 citations

Design of Sequence-Specific DNA-Binding Molecules

1986 • 840 citations

Oxidases and Related Redox Systems

1982 • 818 citations

Superoxide‐dependent formation of hydroxyl radicals in the presence of iron chelates

1978 • 748 citations

Hemoglobin. A biologic fenton reagent.

1984 • 582 citations

Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide.

1986 • 520 citations

Bipyridylium quaternary salts and related compounds. V. Pulse radiolysis studies of the reaction of paraquat radical with oxygen. Implications for the mode of action of bipyridyl herbicides

1973 • 518 citations

Hydroxyl radical "footprinting": high-resolution information about DNA-protein contacts and application to lambda repressor and Cro protein.

1986 • 518 citations

Skin Tumor-Promoting Activity of Benzoyl Peroxide, a Widely Used Free Radical-Generating Compound

1981 • 510 citations

Cleavage of DNA with methidiumpropyl-EDTA-iron(II): reaction conditions and product analyses

1984 • 477 citations

Hydrogen peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymerase.

1986 • 466 citations

In vivo inhibition of superoxide dismutase in mice by diethyldithiocarbamate.

1976 • 457 citations

Phagocytes as Carcinogens: Malignant Transformation Produced by Human Neutrophils

1985 • 443 citations

DNA strand scission by enzymically generated oxygen radicals

1981 • 428 citations

Inducible repair of oxidative DNA damage in Escherichia coli

1983 • 415 citations

Regulation of the synthesis of superoxide dismutase in Escherichia coli. Induction by methyl viologen.

1977 • 396 citations

ADP-ribosylation in mammalian cell ghosts. Dependence of poly(ADP-ribose) synthesis on strand breakage in DNA.

1980 • 378 citations

In vivo formation of single-strand breaks in DNA by hydrogen peroxide is mediated by the Haber-Weiss reaction

1984 • 350 citations

Bimodal pattern of killing of DNA-repair-defective or anoxically grown Escherichia coli by hydrogen peroxide

1986 • 349 citations

Cell killing and DNA damage by hydrogen peroxide are mediated by intracellular iron

1984 • 334 citations

On the cytotoxicity of vitamin C and metal ions

1983 • 328 citations

Overproduction of human Cu/Zn-superoxide dismutase in transfected cells: extenuation of paraquat-mediated cytotoxicity and enhancement of lipid peroxidation.

1986 • 322 citations

Mammalian Cells Are Not Killed by DNA Single-Strand Breaks Caused by Hydroxyl Radicals from Hydrogen Peroxide

1985 • 305 citations

AppppA and related adenylylated nucleotides are synthesized as a consequence of oxidation stress

1984 • 303 citations

Hydrogen peroxide kills Staphylococcus aureus by reacting with staphylococcal iron to form hydroxyl radical.

1981 • 280 citations

Antioxidants, Aging, and Longevity

1984 • 279 citations

Role of superoxide in deoxyribonucleic acid strand scission

1980 • 276 citations

Mutagenicity of oxygen free radicals.

1982 • 270 citations

Comparison of superoxide with other reducing agents in the biological production of hydroxyl radicals

1979 • 268 citations

A yeast mutant lacking mitochondrial manganese-superoxide dismutase is hypersensitive to oxygen.

1986 • 262 citations

Stimulated Human Phagocytes Produce Cytogenetic Changes in Cultured Mammalian Cells

1983 • 262 citations

Inhibition of Tumor Promotion by a Biomimetic Superoxide Dismutase

1983 • 256 citations

Chemical analysis of DNA alterations

1968 • 222 citations

Active oxygen acts as a promoter of transformation in mouse embryo C3H/10T1/2/C18 fibroblasts.

1984 • 208 citations

Dimethyl sulfoxide prevents DNA nicking mediated by ionizing radiation or iron/hydrogen peroxide-generated hydroxyl radical.

1981 • 192 citations

Quinones in Biology: Functions in electron transfer and oxygen activation

1986 • 183 citations

Selenium and vitamin E inhibit radiogenic and chemically induced transformation in vitro via different mechanisms.

1986 • 183 citations

Activation of a c-K- ras Oncogene by Somatic Mutation in Mouse Lymphomas Induced by Gamma Radiation

1984 • 180 citations

Oxidative destruction of DNA by the adriamycin-iron complex

1984 • 173 citations

Comparison of the effects of hydrogen peroxide and X-ray irradiation on toxicity, mutation, and DNA damage/repair in mammalian cells (V-79)

1981 • 163 citations

Benzo[a]pyrenedione/benzo[a]pyrenediol oxidation-reduction couples and the generation of reactive reduced molecular oxygen

1977 • 158 citations

Cobalt(II) ion as a promoter of hydroxyl radical and possible ‘crypto-hydroxyl’ radical formation under physiological conditions. Differential effects of hydroxyl radical scavengers

1985 • 158 citations

The role of superoxide in the destruction of erythrocyte targets by human neutrophils.

1980 • 156 citations

Activation of c-Ha-ras-1 proto-oncogene by in vitro modification with a chemical carcinogen, benzo(a)pyrene diol-epoxide

1984 • 154 citations

Protease inhibitors antagonize the activation of polymorphonuclear leukocyte oxygen consumption

1979 • 150 citations

The inhibition of croton oil-promoted mouse skin tumorigenesis by steroid hormones.

1972 • 145 citations

Protection of mammalian cells by o-phenanthroline from lethal and DNA-damaging effects produced by active oxygen species

1985 • 139 citations

5,6-Saturated thymine lesions in DNA: production by ultraviolet light or hydrogen peroxide

1982 • 133 citations

Degradation of deoxyribonucleic acid by a 1,10-phenanthroline-copper complex: the role of hydroxyl radicals

1980 • 132 citations

Stimulation of human polymorphonuclear leukocyte superoxide anion radical production by tumor promoters

1981 • 131 citations

Role of reactive oxygen in tumor promotion: implication of superoxide anion in promotion of neoplastic transformation in JB-6 cells by TPA

1985 • 129 citations

Radiation Chemistry of Aqueous Solutions

1948 • 126 citations

Modifiers of free radicals inhibit in vitro the oncogenic actions of x-rays, bleomycin, and the tumor promoter 12-O-tetradecanoylphorbol 13-acetate.

1983 • 126 citations

Correlation between cytotoxic effect of hydrogen peroxide and the yield of DNA strand breaks in cells of different species

1984 • 124 citations

The production of DNA strand breaks in human leukocytes by superoxide anion may involve a metabolic process.

1985 • 124 citations

OXYGEN‐DEPENDENCE OF NEAR UV (365 NM) LETHALITY AND THE INTERACTION OF NEAR UV AND X‐RAYS IN TWO MAMMALIAN CELL LINES

1976 • 123 citations

Site-specific cleavage of double-strand DNA by hydroperoxide of linoleic acid

1984 • 123 citations

DNA strand breaks in human leukocytes induced by superoxide anion, hydrogen peroxide and tumor promoters are repaired slowly compared to breaks induced by ionizing radiation

1986 • 123 citations

Radioresistant DNA synthesis: an intrinsic feature of ataxia telangiectasia

1981 • 117 citations

Secondary structure specificity of the nuclease activity of the 1,10-phenanthroline-copper complex.

1984 • 110 citations

Tumor promoter phorbol 12-myristate 13-acetate induces a clastogenic factor in human lymphocytes.

1982 • 108 citations

The metal-mediated formation of hydroxyl radical by aqueous extracts of cigarette tar

1985 • 108 citations

DNA-ferrous iron catalyzed hydroxyl free radical formation from hydrogen peroxide

1981 • 108 citations

Radiation-like modification of bases in DNA exposed to tumor promoter-activated polymorphonuclear leukocytes.

1986 • 106 citations

Increased microsomal oxidation of hydroxyl radical scavenging agents and ethanol after chronic consumption of ethanol

1983 • 105 citations

Effect of 3-aminobenzamide on DNA strand-break rejoining and cytotoxicity in CHO cells treated with hydrogen peroxide

1986 • 104 citations

On the Use of OH · Scavengers in Biological Systems

1984 • 100 citations

ACTION OF HYDROGEN PEROXIDE ON HUMAN FIBROBLAST IN CULTURE

1979 • 99 citations

Genetic damage in CHO cells exposed to enzymically generated active oxygen species

1984 • 84 citations

Clastogenic action of hydroperoxy-5,8,11,13-icosatetraenoic acids on the mouse embryo fibroblasts C3H/10T1/2.

1987 • 82 citations

Products of DNA cleavage by the 1,10-phenanthroline-copper complex. Inhibitors of Escherichia coli DNA polymerase I.

1982 • 77 citations

Fluorescent light-induced chromosome damage and its prevention in mouse cells in culture.

1978 • 77 citations

Iron-mediated induction of sister-chromatid exchanges by hydrogen peroxide and superoxide anion

1987 • 75 citations

Induction of superoxide dismutase, chromosomal aberrations and sister-chromatid exchanges by paraquat in Chinese hamster fibroblasts

1985 • 74 citations

Treatment of lymphocyte cultures with a hypoxanthine-xanthine oxidase system induces the formation of transferable clastogenic material

1985 • 71 citations

The damaging action of hydrogen peroxide on DNA of human fibroblasts is mediated by a non-dialyzable compound

1980 • 70 citations

DNA STRAND BREAKS IN MAMMALIAN CELLS EXPOSED TO LIGHT IN THE PRESENCE OF RIBOFLAVIN AND TRYPTOPHAN

1979 • 68 citations

Effects of O2 on the reactions of activated bleomycin.

1982 • 66 citations

Iron-induced DNA damage and synthesis in isolated rat liver nuclei

1982 • 64 citations

Role of free radicals in the initiation and promotion of radiation transformation in vitro

1984 • 64 citations

Increased superoxide radical production evokes inducible DNA repair in Escherichia coli.

1985 • 55 citations

Tumor promoter phorbol-12-myristate-13-acetate induces poly(ADP)-ribosylation in fibroblasts.

1985 • 55 citations

Do Tumor Promoters Affect DNA After All?

1983 • 53 citations

Exogenous Cu,Zn-superoxide dismutase suppresses the stimulation of neonatal rat hepatocytes' growth by tumor promoters

1984 • 53 citations

Iron(II)-bleomycin. Biochemical and spectral properties in the presence of radical scavengers

1982 • 51 citations

A common pathway for protection of bacteria against damage by solar UVA (334 nm, 365 nm) and an oxidising agent (H2O2)

1985 • 49 citations

Free radical pathology: Inactivation of human α-1-proteinase inhibitor by products from the reaction of nitrogen dioxide with hydrogen peroxide and the etiology of emphysema

1982 • 42 citations

The reduction of tumor initiating activity and cell mediated mutagenicity of dimethylbenz[a]anthracene by a copper coordination compound

1984 • 38 citations

SISTER CHROMATID EXCHANGES AND CHROMOSOME ABERRATIONS IN HUMAN CELLS INDUCED BY H₂O₂ AND OTHER PHOTOPRODUCTS GENERATED IN FLUORESCENT LIGHT‐EXPOSED MEDIUM

1984 • 38 citations

Investigation of a possible role for superoxide anion production in tumour promotion

1983 • 35 citations

Induction of Single-Strand DNA Breaks in Human Cells by H 2 O 2 Formed in Near-uv (Black Light)-Irradiated Medium

1980 • 34 citations

THE RADIATION CHEMISTRY OF AQUEOUS SOLUTIONS

1961 • 33 citations

Mechanisms for the production of DNA damage in cultured human and hamster cells irradiated with light from fluorescent lamps, sunlamps, and the sun

1980 • 24 citations

The lethal oxidase of leucocytes

1983 • 16 citations

An examination of the DNA damaging and repair inhibitory capacity of phorbol myristate acetate in human diploid fibroblasts

1985 • 12 citations

Fixation of aromatic hydrocarbons to proteins and DNA mediated by superoxide radicals and other activated oxygen species

1982 • 5 citations

Interaction of the Superoxide Radical With Peroxidase and with Other Iron Complexes

1982 • 3 citations