Galantamine Is an Allosterically Potentiating Ligand of Neuronal Nicotinic but Not of Muscarinic Acetylcholine Receptors

Galantamine in AD

2000 • 864 citations

Efficacy and safety of galantamine in patients with mild to moderate Alzheimer's disease: multicentre randomised controlled trial

2000 • 609 citations

Chimaeric nicotinic–serotonergic receptor combines distinct ligand binding and channel specificities

1993 • 401 citations

Allosteric sensitization of nicotinic receptors by galantamine, a new treatment strategy for Alzheimer’s disease

2001 • 299 citations

Agonist responses of neuronal nicotinic acetylcholine receptors are potentiated by a novel class of allosterically acting ligands.

1996 • 222 citations

Allosteric modulation of nicotinic acetylcholine receptors as a treatment strategy for Alzheimer's disease

2000 • 216 citations

α4 but Not α3 and α7 Nicotinic Acetylcholine Receptor Subunits Are Lost from the Temporal Cortex in Alzheimer's Disease

1999 • 197 citations

Rivastigmine

1998 • 179 citations

Galantamine: Effect on nicotinic receptor binding, acetylcholinesterase inhibition, and learning

2001 • 177 citations

Quantitative assessment of nicotinic acetylcholine receptor proteins in the cerebral cortex of Alzheimer patients

2000 • 176 citations

The Nicotinic Allosteric Potentiating Ligand Galantamine Facilitates Synaptic Transmission in the Mammalian Central Nervous System

2002 • 175 citations

Human alpha4beta2 neuronal nicotinic acetylcholine receptor in HEK 293 cells: A patch-clamp study.

1996 • 169 citations

Stable expression and pharmacological properties of the human α7 nicotinic acetylcholine receptor

1995 • 166 citations

Potentiation and Inhibition of Neuronal Nicotinic Receptors by Atropine: Competitive and Noncompetitive Effects

1997 • 157 citations

Expression of nicotinic acetylcholine receptor subunits in the cerebral cortex in Alzheimer’s disease: histotopographical correlation with amyloid plaques and hyperphosphorylated‐tau protein

1999 • 155 citations

Human α4β2 Neuronal Nicotinic Acetylcholine Receptor in HEK 293 Cells: A Patch-Clamp Study

1996 • 154 citations

Galantamine is an allosterically potentiating ligand of the human α4/β2 nAChR

2000 • 144 citations

Diversity of nicotinic acetylcholine receptors in rat brain. V. alpha-Bungarotoxin-sensitive nicotinic receptors in olfactory bulb neurons and presynaptic modulation of glutamate release.

1996 • 133 citations

Assessing Patterns of Agitation in Alzheimerʼs Disease Patients with the Cohen-Mansfield Agitation Inventory

1997 • 129 citations

Identification and functional characterization of a new agonist site on nicotinic acetylcholine receptors of cultured hippocampal neurons.

1993 • 122 citations

Physostigmine, galanthamine and codeine act as ‘noncompetitive nicotinic receptor agonists’ on clonal rat pheochromocytoma cells

1995 • 117 citations

CNS Neurotransmitters and Neuromodulators: Dopamine

1996 • 105 citations

Physostigmine and galanthamine: probes for a novel binding site on the alpha 4 beta 2 subtype of neuronal nicotinic acetylcholine receptors stably expressed in fibroblast cells.

1994 • 103 citations

Inhibition of Acetylcholinesterase Activity in Human Brain Tissue and Erythrocytes by Galanthamine, Physostigmine and Tacrine

1991 • 96 citations

Pharmacokinetics of galanthamine in humans and corresponding cholinesterase inhibition

1991 • 91 citations

Photoaffinity labeling of Torpedo acetylcholine receptor by physostigmine

1993 • 79 citations

A second pathway of activation of the Torpedo acetylcholine receptor channel

1991 • 70 citations

Minireview: Nicotinic Acetylcholine Receptors on Hippocampal Neurons: Distribution on the Neuronal Surface and Modulation of Receptor Activity

1997 • 67 citations

Competitive Potentiation of Acetylcholine Effects on Neuronal Nicotinic Receptors by Acetylcholinesterase‐Inhibiting Drugs

2000 • 61 citations

.alpha.-Bungarotoxin and the competing antibody WF6 interact with different amino acids within the same cholinergic subsite

1991 • 57 citations

Monoclonal antibodies FK1 and WF6 define two neighboring ligand binding sites on Torpedo acetylcholine receptor alpha-polypeptide.

1994 • 55 citations

Galantamine: Effect on nicotinic receptor binding, acetylcholinesterase inhibition, and learning

2001 • 41 citations

Differential inhibition of [ 3 H]-oxotremorine-M and [ 3 H]-quinuclinidyl benzilate binding to muscarinic receptors in rat brain membranes with acetylcholinesterase inhibitors

2001 • 36 citations

Muscarinic cholinoceptive neurons in the frontal cortex in Alzheimer's disease

1991 • 36 citations

Modulatory control by non-competitive agonists of nicotinic cholinergic neurotransmission in the central nervous system

1995 • 28 citations

Stable expression in HEK‐293 cells of the rat α3/β4 subtype of neuronal nicotinic acetylcholine receptor

1996 • 28 citations

Clinical benefits of a new piperidine-class AChE inhibitor

1999 • 22 citations

Ligand binding to the membrane-bound acetylcholine receptor from Torpedo marmorata: a complete mathematical analysis

1992 • 19 citations

Distribution of Nicotinic Receptors in the CNS

2020 • 7 citations

Preclinical and Clinical Studies with Galanthamine

1991 • 5 citations