Allosteric modulation of nicotinic acetylcholine receptors as a treatment strategy for Alzheimer's disease

The cholinergic hypothesis of Alzheimer's disease: a review of progress

1999 • 2,013 citations

A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's disease

1998 • 1,575 citations

Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus

1997 • 1,142 citations

Nicotinic acetylcholine involvement in cognitive function in animals

1998 • 689 citations

Nicotinic acetylcholine binding sites in Alzheimer's disease

1986 • 485 citations

Transmitter leakage from motor nerve endings

1977 • 443 citations

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1997 • 443 citations

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1997 • 431 citations

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1995 • 385 citations

Cholinesterase Inhibitors in the Treatment of Alzheimer??s Disease

1998 • 369 citations

Reduced number of [3H]nicotine and [3H]acetylcholine binding sites in the frontal cortex of Alzheimer brains

1986 • 360 citations

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1999 • 334 citations

alpha-Bungarotoxin-sensitive hippocampal nicotinic receptor channel has a high calcium permeability

1995 • 264 citations

Nicotinic Receptor Function in Schizophrenia

1996 • 261 citations

Nicotinic Receptor Activation in Human Cerebral Cortical Interneurons: a Mechanism for Inhibition and Disinhibition of Neuronal Networks

2000 • 251 citations

Nicotine-induced protection of cultured cortical neurons againstN-methyl-D-aspartate receptor-mediated glutamate cytotoxicity

1994 • 240 citations

Agonist responses of neuronal nicotinic acetylcholine receptors are potentiated by a novel class of allosterically acting ligands.

1996 • 222 citations

Kinetic Analysis of Regional (S)(-)11C-Nicotine Binding in Normal and Alzheimer Brains In Vivo Assessment Using Positron Emission Tomography

1995 • 211 citations

α4 but Not α3 and α7 Nicotinic Acetylcholine Receptor Subunits Are Lost from the Temporal Cortex in Alzheimer's Disease

1999 • 197 citations

Stimulation of α4β2 nicotinic acetylcholine receptors inhibits β-amyloid toxicity

1998 • 192 citations

Acute effects of the selective cholinergic channel activator (nicotinic agonist) ABT-418 in Alzheimer's disease

1999 • 169 citations

Potentiation and Inhibition of Neuronal Nicotinic Receptors by Atropine: Competitive and Noncompetitive Effects

1997 • 157 citations

Expression of nicotinic acetylcholine receptor subunits in the cerebral cortex in Alzheimer’s disease: histotopographical correlation with amyloid plaques and hyperphosphorylated‐tau protein

1999 • 155 citations

Nicotinic cholinoceptive neurons of the frontal cortex are reduced in Alzheimer's disease

1991 • 149 citations

Clinical Diagnosis and Management of Alzheimer's Disease

2006 • 145 citations

The reversible cholinesterase inhibitor physostigmine has channel-blocking and agonist effects on the acetylcholine receptor-ion channel complex.

1985 • 130 citations

Identification and functional characterization of a new agonist site on nicotinic acetylcholine receptors of cultured hippocampal neurons.

1993 • 122 citations

Physostigmine and galanthamine: probes for a novel binding site on the alpha 4 beta 2 subtype of neuronal nicotinic acetylcholine receptors stably expressed in fibroblast cells.

1994 • 103 citations

New approach to drug therapy in Alzheimer's dementia Alfred Maelicke and Edson X. Albuquerque

1996 • 92 citations

Sustained Nicotine Exposure Differentially Affects α3β2 and α4β2 Neuronal Nicotinic Receptors Expressed in Xenopus Oocytes

1996 • 84 citations

Kinetic Properties and Regulation of GABAA Receptor Channels

1992 • 69 citations

Ligand Binding and Activation of Rat Nicotinic α4β2 Receptors Stably Expressed in HEK293 Cells

1999 • 67 citations

NBD-5-acylcholine: fluorescent analog of acetylcholine and agonist at the neuromuscular junction.

1979 • 58 citations

Biochemical Aspects of Cholinergic Excitation

1984 • 58 citations

The hypothesis of an ambient level of acetylcholine in the central nervous system

1998 • 56 citations

CNS Nicotinic Receptors

1994 • 48 citations

A Novel Agonist Binding Site on Nicotinic Acetylcholine Receptors

1993 • 44 citations

Effects of a novel cholinergic ion channel agonist SIB-1765F on locomotor activity in rats.

1997 • 43 citations

Modulatory control by non-competitive agonists of nicotinic cholinergic neurotransmission in the central nervous system

1995 • 28 citations

Chapter 9 Nicotinic acetylcholine receptors on hippocampal neurons: cell compartment-specific expression and modulatory control of channel activity

1996 • 27 citations

Long-term treatment with GTS-21 or nicotine enhances water maze performance in aged rats without affecting the density of nicotinic receptor subtypes in neocortex

1996 • 23 citations

Clinical diagnosis and management of Alzheimer's disease

1996 • 11 citations