Mutational analysis of the conserved cysteine-rich region of the human immunodeficiency virus type 1 Tat protein

Cellular uptake of the tat protein from human immunodeficiency virus

1988 • 2,690 citations

SV40-transformed simian cells support the replication of early SV40 mutants

1981 • 2,564 citations

Complete nucleotide sequence of the AIDS virus, HTLV-III

1985 • 2,236 citations

Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein

1988 • 1,488 citations

The Accuracy of Reverse Transcriptase from HIV-1

1988 • 982 citations

Fidelity of HIV-1 Reverse Transcriptase

1988 • 919 citations

Anti-termination of transcription within the long terminal repeat of HIV-1 by tat gene product

1987 • 902 citations

Genome organization and transactivation of the human immunodeficiency virus type 2

1987 • 842 citations

[71] Use of eukaryotic expression technology in the functional analysis of cloned genes

1987 • 834 citations

The location of cis-acting regulatory sequences in the human T cell lymphotropic virus type III (HTLV-III/LAV) long terminal repeat

1985 • 825 citations

Trans-activation of human immunodeficiency virus occurs via a bimodal mechanism

1986 • 730 citations

HTLV-III expression and production involve complex regulation at the levels of splicing and translation of viral RNA

1986 • 673 citations

Regulation of mRNA accumulation by a human immunodeficiency virus trans-activator protein

1987 • 672 citations

Temporal fluctuations in HIV quasispecies in vivo are not reflected by sequential HIV isolations

1989 • 655 citations

HIV-1 Tat protein increases transcriptional initiation and stabilizes elongation

1989 • 577 citations

Location of the Trans -Activating Region on the Genome of Human T-Cell Lymphotropic Virus Type III

1985 • 558 citations

HIV-1 tat trans-activation requires the loop sequence within tar

1988 • 551 citations

Trans -Acting Transcriptional Regulation of Human T-Cell Leukemia Virus Type III Long Terminal Repeat

1985 • 500 citations

Human immunodeficiency virus 1 tat protein binds trans-activation-responsive region (TAR) RNA in vitro.

1989 • 472 citations

Tat Protein from Human Immunodeficiency Virus Forms a Metal-Linked Dimer

1988 • 464 citations

Structural and functional characterization of human immunodeficiency virus tat protein

1989 • 444 citations

Regulatory pathways governing HIV-1 replication

1989 • 401 citations

Structure, sequence, and position of the stem-loop in tar determine transcriptional elongation by tat through the HIV-1 long terminal repeat.

1989 • 357 citations

5′–3′ Exonucleases in phosphorothioate-based oligonucleotide-directed mutagenesis

1988 • 336 citations

Post-transcriptional regulation accounts for the trans-activation of the human T-lymphotropic virus type III

1986 • 325 citations

Elevated levels of mRNA can account for the trans-activation of human immunodeficiency virus.

1986 • 303 citations

Expression and Characterization of the Trans -Activator of HTLV-III/LAV Virus

1986 • 276 citations

Human immunodeficiency virus type 1 LTR TATA and TAR region sequences required for transcriptional regulation.

1989 • 275 citations

Mutational analysis of the conserved basic domain of human immunodeficiency virus tat protein

1989 • 270 citations

A discrete element 3' of human immunodeficiency virus 1 (HIV-1) and HIV-2 mRNA initiation sites mediates transcriptional activation by an HIV trans activator.

1988 • 270 citations

Multiple functional domains of Tat, thetrans-activator of HIV-1, defined by mutational analysis

1989 • 251 citations

Trans-activation of human immunodeficiency virus gene expression is mediated by nuclear events.

1987 • 246 citations

Mutational analysis of the trans-activation-responsive region of the human immunodeficiency virus type I long terminal repeat

1988 • 235 citations

Functional domains required for tat-induced transcriptional activation of the HIV-1 long terminal repeat.

1988 • 193 citations

Site-Directed Mutagenesis of Two Trans-Regulatory Genes ( tat -III, trs ) of HIV-1

1988 • 180 citations

Transcriptional but not translational regulation of HIV-1 by the tat gene product

1988 • 158 citations

The genome organization of STLV-3 is similar to that of the AIDS virus except for a truncated transmembrane protein

1987 • 152 citations

Lytic and transforming functions of individual products of the adenovirus E1A gene

1986 • 136 citations

HIV-1 TAT “activates” presynthesized RNA in the nucleus

1989 • 135 citations

Transactivation induced by human T-lymphotropic virus type III (HTLV III) maps to a viral sequence encoding 58 amino acids and lacks tissue specificity

1986 • 117 citations

Activity of synthetic peptides from the Tat protein of human immunodeficiency virus type 1.

1989 • 96 citations

Missense mutations in an infectious human immunodeficiency viral genome: functional mapping of tat and identification of the rev splice acceptor.

1988 • 91 citations

Synthesis of the complete trans-activation gene product of human T-lymphotropic virus type III in Escherichia coli: demonstration of immunogenicity in vivo and expression in vitro.

1986 • 90 citations

Trans-activation of the human immunodeficiency virus long terminal repeat sequences, expressed in an adenovirus vector, by the adenovirus E1A 13S protein.

1988 • 57 citations