Expanding the MicroRNA Targeting Code: Functional Sites with Centered Pairing

MicroRNAs

2004 • 33,206 citations

MicroRNAs: Target Recognition and Regulatory Functions

2009 • 19,026 citations

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

2001 • 9,275 citations

Most mammalian mRNAs are conserved targets of microRNAs

2008 • 8,043 citations

Prediction of Mammalian MicroRNA Targets

2003 • 5,070 citations

Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

2008 • 5,001 citations

Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

2005 • 4,706 citations

Silencing of microRNAs in vivo with ‘antagomirs’

2005 • 3,846 citations

MicroRNA Targeting Specificity in Mammals: Determinants beyond Seed Pairing

2007 • 3,708 citations

The impact of microRNAs on protein output

2008 • 3,546 citations

Widespread changes in protein synthesis induced by microRNAs

2008 • 3,372 citations

RNA interference is mediated by 21- and 22-nucleotide RNAs

2001 • 3,271 citations

Argonaute2 Is the Catalytic Engine of Mammalian RNAi

2004 • 2,620 citations

MicroRNAs AND THEIR REGULATORY ROLES IN PLANTS

2006 • 2,583 citations

Expression profiling reveals off-target gene regulation by RNAi

2003 • 2,294 citations

Computational Identification of Plant MicroRNAs and Their Targets, Including a Stress-Induced miRNA

2004 • 2,226 citations

microRNA-Directed Phasing during Trans-Acting siRNA Biogenesis in Plants

2005 • 2,175 citations

A microRNA in a Multiple-Turnover RNAi Enzyme Complex

2002 • 2,052 citations

Human Argonaute2 Mediates RNA Cleavage Targeted by miRNAs and siRNAs

2004 • 1,887 citations

Requirement of bic/microRNA-155 for Normal Immune Function

2007 • 1,807 citations

The UCSC Genome Browser database: update 2011

2010 • 1,753 citations

MicroRNA-Directed Cleavage of HOXB8 mRNA

2004 • 1,680 citations

Zebrafish MiR-430 Promotes Deadenylation and Clearance of Maternal mRNAs

2006 • 1,582 citations

Cleavage of Scarecrow-like mRNA Targets Directed by a Class of Arabidopsis miRNA

2002 • 1,569 citations

Human RISC Couples MicroRNA Biogenesis and Posttranscriptional Gene Silencing

2005 • 1,527 citations

The Widespread Impact of Mammalian MicroRNAs on mRNA Repression and Evolution

2005 • 1,482 citations

Aligning Multiple Genomic Sequences With the Threaded Blockset Aligner

2004 • 1,473 citations

A diverse and evolutionarily fluid set of microRNAs in Arabidopsis thaliana

2006 • 1,274 citations

The microRNAs ofCaenorhabditis elegans

2003 • 1,232 citations

Animal MicroRNAs Confer Robustness to Gene Expression and Have a Significant Impact on 3′UTR Evolution

2005 • 1,079 citations

Widespread siRNA “off-target” transcript silencing mediated by seed region sequence complementarity

2006 • 916 citations

3′ UTR seed matches, but not overall identity, are associated with RNAi off-targets

2006 • 865 citations

Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs

2008 • 849 citations

Global identification of microRNA–target RNA pairs by parallel analysis of RNA ends

2008 • 805 citations

Mammalian microRNAs: experimental evaluation of novel and previously annotated genes

2010 • 786 citations

Argonaute2 Cleaves the Anti-Guide Strand of siRNA during RISC Activation

2005 • 759 citations

Position-specific chemical modification of siRNAs reduces “off-target” transcript silencing

2006 • 758 citations

Endogenous siRNA and miRNA Targets Identified by Sequencing of the Arabidopsis Degradome

2008 • 737 citations

Early origins and evolution of microRNAs and Piwi-interacting RNAs in animals

2008 • 712 citations

MicroRNA control of PHABULOSA in leaf development: importance of pairing to the microRNA 5′ region

2004 • 685 citations

Evolution of microRNA genes by inverted duplication of target gene sequences in Arabidopsis thaliana

2004 • 603 citations

miR-24 Inhibits Cell Proliferation by Targeting E2F2, MYC, and Other Cell-Cycle Genes via Binding to “Seedless” 3′UTR MicroRNA Recognition Elements

2009 • 589 citations

The UCSC Genome Browser database: update 2010

2009 • 583 citations

Kinetic analysis of the RNAi enzyme complex

2004 • 537 citations

Molecular Basis for Target RNA Recognition and Cleavage by Human RISC

2007 • 529 citations

Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes

2009 • 523 citations

RISC is a 5′ phosphomonoester-producing RNA endonuclease

2004 • 409 citations

A human, ATP-independent, RISC assembly machine fueled by pre-miRNA

2005 • 406 citations

Slicer function of Drosophila Argonautes and its involvement in RISC formation

2005 • 389 citations

AtXRN4 Degrades mRNA in Arabidopsis and Its Substrates Include Selected miRNA Targets

2004 • 372 citations

Decay of mRNAs targeted by RISC requires XRN1, the Ski complex, and the exosome

2005 • 337 citations

RNAi-Mediated Allelic trans-Interaction at the Imprinted Rtl1/Peg11 Locus

2005 • 313 citations

Designing siRNA That Distinguish between Genes That Differ by a Single Nucleotide

2006 • 262 citations

The RNA-Induced Silencing Complex Is a Mg2+-Dependent Endonuclease

2004 • 261 citations

Comparison of siRNA-induced off-target RNA and protein effects

2007 • 152 citations

Experimental validation of the importance of seed complement frequency to siRNA specificity

2008 • 140 citations

Effects of magnesium ions on the stabilization of RNA oligomers of defined structures

2002 • 126 citations

Distinct passenger strand and mRNA cleavage activities of human Argonaute proteins

2009 • 123 citations

Genome-wide identification of targets of the drosha–pasha/DGCR8 complex

2009 • 106 citations

A large family of ancient repeat elements in the human genome is under strong selection

2006 • 96 citations

Concentration, compartmentation and metabolic function of intracellular free Mg2+.

2006 • 90 citations

Cleavage of the Star Strand Facilitates Assembly of Some MicroRNAs into Ago2-containing Silencing Complexes in Mammals

2008 • 38 citations

Structural features of the guide:target RNA duplex required for archaeal box C/D sRNA-guided nucleotide 2′-O-methylation

2007 • 25 citations