Cleavage of the Star Strand Facilitates Assembly of Some MicroRNAs into Ago2-containing Silencing Complexes in Mammals

MicroRNAs

2004 • 33,206 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

2008 • 5,001 citations

The nuclear RNase III Drosha initiates microRNA processing

2003 • 4,966 citations

Role for a bidentate ribonuclease in the initiation step of RNA interference

2001 • 4,804 citations

Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs

2003 • 2,893 citations

Nuclear Export of MicroRNA Precursors

2003 • 2,662 citations

The Microprocessor complex mediates the genesis of microRNAs

2004 • 2,625 citations

Argonaute2 Is the Catalytic Engine of Mammalian RNAi

2004 • 2,620 citations

microRNA Functions

2007 • 2,524 citations

MicroRNA biogenesis: coordinated cropping and dicing

2005 • 2,443 citations

The Drosha-DGCR8 complex in primary microRNA processing

2004 • 2,096 citations

TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing

2005 • 2,046 citations

Human Argonaute2 Mediates RNA Cleavage Targeted by miRNAs and siRNAs

2004 • 1,887 citations

Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans Developmental Timing

2001 • 1,847 citations

MicroRNA-Directed Cleavage of HOXB8 mRNA

2004 • 1,680 citations

Intronic microRNA precursors that bypass Drosha processing

2007 • 1,542 citations

Molecular Basis for the Recognition of Primary microRNAs by the Drosha-DGCR8 Complex

2006 • 1,510 citations

Small non-coding RNAs in animal development

2008 • 1,356 citations

Passenger-Strand Cleavage Facilitates Assembly of siRNA into Ago2-Containing RNAi Enzyme Complexes

2005 • 1,106 citations

miRiad Roles for the miR-17-92 Cluster in Development and Disease

2008 • 1,067 citations

Getting to the Root of miRNA-Mediated Gene Silencing

2008 • 1,037 citations

ATP Requirements and Small Interfering RNA Structure in the RNA Interference Pathway

2001 • 1,008 citations

The Mirtron Pathway Generates microRNA-Class Regulatory RNAs in Drosophila

2007 • 1,000 citations

Human embryonic stem cells express a unique set of microRNAs

2004 • 960 citations

Genomics of microRNA

2006 • 872 citations

Argonaute2 Cleaves the Anti-Guide Strand of siRNA during RISC Activation

2005 • 759 citations

Purified Argonaute2 and an siRNA form recombinant human RISC

2005 • 736 citations

Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing

2004 • 623 citations

Sequence-Specific Inhibition of Small RNA Function

2004 • 577 citations

Kinetic analysis of the RNAi enzyme complex

2004 • 537 citations

microRNAs join the p53 network — another piece in the tumour-suppression puzzle

2007 • 535 citations

Small RNAs: Classification, Biogenesis, and Function

2005 • 465 citations

Drosophila microRNAs Are Sorted into Functionally Distinct Argonaute Complexes after Production by Dicer-1

2007 • 411 citations

RISC is a 5′ phosphomonoester-producing RNA endonuclease

2004 • 409 citations

Cleavage of the siRNA passenger strand during RISC assembly in human cells

2006 • 386 citations

Sorting of Drosophila Small Silencing RNAs

2007 • 370 citations

The RNA-Induced Silencing Complex Is a Mg2+-Dependent Endonuclease

2004 • 261 citations

MicroRNA miR-199a* Regulates the MET Proto-oncogene and the Downstream Extracellular Signal-regulated Kinase 2 (ERK2)

2008 • 207 citations

In vitro analysis of RNA interference in Drosophila melanogaster

2003 • 129 citations

Small RNAs: Keeping Stem Cells in Line

2008 • 108 citations

Crystal structure of human DGCR8 core

2007 • 108 citations

Drosha in Primary MicroRNA Processing

2006 • 105 citations

Conversion of pre-RISC to holo-RISC by Ago2 during assembly of RNAi complexes

2006 • 100 citations

Structural features of small RNA precursors determine Argonaute loading in Caenorhabditis elegans

2007 • 91 citations

Two molecular features contribute to the Argonaute specificity for the microRNA and RNAi pathways in C. elegans

2008 • 39 citations