Metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by human cytochrome P4501A1, P4501A2 and P4501B1

Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes

1991 • 997 citations

Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1.

1996 • 793 citations

A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)

1991 • 538 citations

Complete cDNA sequence of a human dioxin-inducible mRNA identifies a new gene subfamily of cytochrome P450 that maps to chromosome 2.

1994 • 503 citations

The prostate: a target for carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) derived from cooked foods.

1997 • 392 citations

Mutagens-carcinogens in foods.

1983 • 372 citations

The isolation and identification of a new mutagen from fried ground beef: 2-amino-l-methyl-6-phenylimidazo[4, 5-b]pyridine (PhIP)

1986 • 283 citations

Occurrence, identification, and bacterial mutagenicity of heterocyclic amines in cooked food

1991 • 258 citations

Mouse cytochrome P-450EF, representative of a new 1B subfamily of cytochrome P-450s. Cloning, sequence determination, and tissue expression.

1994 • 209 citations

Presence of carcinogenic heterocyclic amines in urine of healthy volunteers eating normal diet, but not of inpatients receiving parenteral alimentation

1991 • 184 citations

Metabolism of carcinogenic heterocyclic and aromatic amines by recombinant human cytochrome P450 enzymes

1997 • 124 citations

Intra- and interindividual variability in systemic exposure in humans to 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline and 2-amino-1-methyl- 6-phenylimidazo[4,5-b]pyridine, carcinogens present in cooked beef.

1992 • 121 citations

Development of a human lymphoblastoid cell line constitutively expressing human CYP1B1 cDNA: substrate specificity with model substrates and promutagens

1997 • 108 citations

Differential rates of metabolic activation and detoxication of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by different cytochrome P450 enzymes

1990 • 100 citations

Basic Environmental Toxicology

2019 • 92 citations

Some perspectives on the nutritional aspects of breast cancer research. Food-derived heterocyclic amines as etiologic agents in human mammary cancer

1994 • 90 citations

Formation of a glutathione conjugate and a semistable transportable glucuronide conjugate of N²-oxidized species of 2-amino-1-methyl-6phenylimidazo[4,5-b]pyridine (PHIP) in rat liver

1991 • 84 citations

Metabolism of the food derived mutagen and carcinogen 2-amino-1-methyl-6-phnylimidazo(4,5-b)pyridine (PhIP) by human liver microsomes

1994 • 84 citations

Genotoxicity of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP): formation of 2-hydroxamino-PhIP, a directly acting genotixic metabolite

1989 • 80 citations

Activation of 2‐Hydroxyamino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridne by cDNA‐expressed Human and Rat Arylsulfotransferases

1994 • 76 citations

Metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) by human cytochrome P4501B1

1997 • 68 citations

Human hepatic CYP1A1 and CYP1A2 content, determined with specific anti-peptide antibodies, correlates with the mutagenic activation of PhIP

1993 • 67 citations

Dietary carcinogens and mammary carcinogenesis. Induction of rat mammary carcinomas by administration of heterocyclin amines in cooked foods

1994 • 66 citations

Activation of 2-amino-1-methyl-6-phenyimidazo[4,5-b] pyridine (PhIP) to mutagenic metabolites

1990 • 56 citations

Development of a human lymphoblastoid cell line constitutively expressing human CYP1A1 cDNA: substrate specificity with model substrates and promutagens

1994 • 55 citations

Coexpression of cytochrome P4502A6 and human NADPH-P450 oxidoreductase in the baculovirus system.

1997 • 41 citations

Metabolic formation, synthesis and genotoxicity of the N-hydroxy derivative of the food mutagen 2-amino-1-methyl–6-phenylimidazo (4, 5–b) pyridine (PhIP)

1991 • 37 citations

A rabbit liver constitutive form of cytochrome P450 responsible for amphetamine deamination

1989 • 16 citations

Xenobiotic Metabolism

1995 • 3 citations