Ca2+-calmodulin-dependent phosphodiesterase (PDE1): Current perspectives

Calcium signalling: dynamics, homeostasis and remodelling

2003 • 5,215 citations

A model for receptor-regulated calcium entry

1986 • 2,535 citations

Structure and Regulation of Voltage-Gated Ca²⁺ Channels

2000 • 2,264 citations

NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones

1986 • 1,842 citations

Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol

1999 • 1,456 citations

A cyclic nucleotide-gated conductance in olfactory receptor cilia

1987 • 1,134 citations

Three-dimensional structure of calmodulin

1985 • 1,035 citations

Structure of calmodulin refined at 2.2 Å resolution

1988 • 1,019 citations

The TRP Channels, a Remarkably Functional Family

2002 • 822 citations

Acylation Targets Endothelial Nitric-oxide Synthase to Plasmalemmal Caveolae

1996 • 798 citations

Identification of a Specialized Adenylyl Cyclase That May Mediate Odorant Detection

1990 • 695 citations

Signal-dependent membrane targeting by pleckstrin homology (PH) domains

2000 • 692 citations

Novel Single Chain cAMP Sensors for Receptor-induced Signal Propagation

2004 • 665 citations

Modulation of Calmodulin Plasticity in Molecular Recognition on the Basis of X-Ray Structures

1993 • 615 citations

Spatially Resolved Dynamics of cAMP and Protein Kinase A Subunits in Aplysia Sensory Neurons

1993 • 549 citations

Calcium dependent phosphodiesterase activity and its activating factor (PAF) from brain

1970 • 491 citations

A genetically encoded, fluorescent indicator for cyclic AMP in living cells

1999 • 476 citations

Assembly of Trp1 in a Signaling Complex Associated with Caveolin-Scaffolding Lipid Raft Domains

2000 • 403 citations

Detection in Living Cells of Ca2+-dependent Changes in the Fluorescence Emission of an Indicator Composed of Two Green Fluorescent Protein Variants Linked by a Calmodulin-binding Sequence

1997 • 389 citations

Protein activator of cyclic 3′:5′-nucleotide phosphodiesterase of bovine or rat brain also activates its adenylate cyclase

1975 • 361 citations

Regulation and organization of adenylyl cyclases and cAMP

2003 • 354 citations

Structural Basis for the Autoinhibition of Calcium/Calmodulin-Dependent Protein Kinase I

1996 • 329 citations

Atomic Structure of PDE4: Insights into Phosphodiesterase Mechanism and Specificity

2000 • 322 citations

Solution structure of Ca(2+)-calmodulin reveals flexible hand-like properties of its domains.

2001 • 320 citations

Hydrolysis of Cyclic Guanosine and Adenosine 3',5'-Monophosphates by Rat and Bovine Tissues

1970 • 303 citations

A subset of olfactory neurons that selectively express cGMP-stimulated phosphodiesterase (PDE2) and guanylyl cyclase-D define a unique olfactory signal transduction pathway

1997 • 302 citations

A uniform extracellular stimulus triggers distinct cAMP signals in different compartments of a simple cell

2001 • 282 citations

A Glutamine Switch Mechanism for Nucleotide Selectivity by Phosphodiesterases

2004 • 279 citations

Subcellular targeting by membrane lipids

2001 • 259 citations

The cyclic AMP phosphodiesterase encoded by the drosophila dunce gene is concentrated in the mushroom body neuropil

1991 • 253 citations

An Autoinhibitory Control Element Defines Calcium-regulated Isoforms of Nitric Oxide Synthase

1997 • 237 citations

Cloning and characterization of the low-affinity cyclic AMP phosphodiesterase gene of Saccharomyces cerevisiae.

1987 • 221 citations

On the role of methionine residues in the sequence-independent recognition of nonpolar protein surfaces

1991 • 213 citations

Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons.

1995 • 190 citations

[30] Assay of cyclic nucleotide phosphodiesterases with radioactive substrates

1974 • 184 citations

Sustained Endothelial Nitric-oxide Synthase Activation Requires Capacitative Ca2+ Entry

2000 • 173 citations

Phosphodiesterases and Cyclic Nucleotide Signaling in Endocrine Cells

2000 • 172 citations

Functional Co-localization of Transfected Ca2+-stimulable Adenylyl Cyclases with Capacitative Ca2+ Entry Sites

1996 • 168 citations

Calcium/calmodulin-activated phosphodiesterase expressed in olfactory receptor neurons

1992 • 164 citations

In Vivo Assessment of Local Phosphodiesterase Activity Using Tailored Cyclic Nucleotide–Gated Channels as Camp Sensors

2001 • 163 citations

Capacitative Ca 2+ Entry Exclusively Inhibits cAMP Synthesis in C6-2B Glioma Cells

1995 • 163 citations

TAPAS-1, a Novel Microdomain within the Unique N-terminal Region of the PDE4A1 cAMP-specific Phosphodiesterase That Allows Rapid, Ca2+-triggered Membrane Association with Selectivity for Interaction with Phosphatidic Acid

2002 • 158 citations

The Calmodulin-dependent Phosphodiesterase Gene PDE1C Encodes Several Functionally Different Splice Variants in a Tissue-specific Manner

1996 • 157 citations

Arachidonic Acid Activates the Noncapacitative Entry of Ca2+ during [Ca2+] Oscillations

1996 • 151 citations

Identification of a conserved domain among cyclic nucleotide phosphodiesterases from diverse species.

1986 • 151 citations

Calmodulin Is a Limiting Factor in the Cell

2002 • 150 citations

Crystal structure of calmodulin

1986 • 149 citations

Isolation and Characterization of cDNAs Corresponding to Two Human Calcium, Calmodulin-regulated, 3′,5′-Cyclic Nucleotide Phosphodiesterases

1996 • 137 citations

Muscarinic cholinergic receptor-mediated activation of phosphodiesterase.

1982 • 133 citations

Calmodulin-dependent cyclic nucleotide phosphodiesterase (PDE1)

1999 • 131 citations

Regulation of the Ca2+-inhibitable Adenylyl Cyclase Type VI by Capacitative Ca2+ Entry Requires Localization in Cholesterol-rich Domains

2000 • 128 citations

Ion permeation through 5-hydroxytryptamine-gated channels in neuroblastoma N18 cells.

1990 • 125 citations

Differential expression of the 61 kDa and 63 kDa calmodulin-dependent phosphodiesterases in the mouse brain

1994 • 124 citations

Identification of Inhibitory and Calmodulin-binding Domains of the PDE1A1 and PDE1A2 Calmodulin-stimulated Cyclic Nucleotide Phosphodiesterases

1995 • 122 citations

A fluorescent resonant energy transfer–based biosensor reveals transient and regional myosin light chain kinase activation in lamella and cleavage furrows

2002 • 119 citations

Differential regulation of bovine brain calmodulin-dependent cyclic nucleotide phosphodiesterase isoenzymes by cyclic AMP-dependent protein kinase and calmodulin-dependent phosphatase.

1985 • 115 citations

Ultrastructural localization of olfactory transduction components: the G protein subunit Golfα and type III adenylyl cyclase

1992 • 114 citations

Dependence of the Ca2+-inhibitable Adenylyl Cyclase of C6–2B Glioma Cells on Capacitative Ca2+ Entry

1998 • 114 citations

Regulation of Signal Transduction by Protein Targeting: The Case for CaMKII

2001 • 105 citations

Light- and Guanosine 5′-3-O-(Thio)triphosphate-sensitive Localization of a G Protein and Its Effector on Detergent-resistant Membrane Rafts in Rod Photoreceptor Outer Segments

2001 • 103 citations

Autoinhibition of Endothelial Nitric-oxide Synthase

1999 • 103 citations

Purification of two calcium/calmodulin-dependent forms of cyclic nucleotide phosphodiesterase by using conformation-specific monoclonal antibody chromatography

1982 • 102 citations

Alpha 1‐adrenoceptor activation of a non‐selective cation current in rabbit portal vein by 1,2‐diacyl‐sn‐glycerol.

1997 • 101 citations

Calcium entry through nicotinic receptor channels and calcium channels in cultured rat superior cervical ganglion cells.

1993 • 99 citations

The Calcium/Calmodulin-dependent Phosphodiesterase PDE1C Down-regulates Glucose-induced Insulin Secretion

1999 • 97 citations

Bradykinin stimulates Ca2+ mobilization in NCB-20 cells leading to direct inhibition of adenylylcyclase. A novel mechanism for inhibition of cAMP production.

1991 • 94 citations

H1-histamine receptors on human astrocytoma cells.

1986 • 94 citations

Residence of Adenylyl Cyclase Type 8 in Caveolae Is Necessary but Not Sufficient for Regulation by Capacitative Ca2+Entry

2002 • 93 citations

Identification and characterization of the type-IVA cyclic AMP-specific phosphodiesterase RD1 as a membrane-bound protein expressed in cerebellum

1995 • 93 citations

Regulation of Ca2+/Calmodulin-dependent Cyclic Nucleotide Phosphodiesterase by the Autophosphorylated Form of Ca2+/Calmodulin-dependent Protein Kinase II

1989 • 88 citations

Monitoring the total available calmodulin concentration in intact cells over the physiological range in free Ca2+

2003 • 88 citations

Inhibition of calmodulin-dependent phosphodiesterase induces apoptosis in human leukemic cells.

1996 • 87 citations

Discriminating between Capacitative and Arachidonate-activated Ca2+ Entry Pathways in HEK293 Cells

1999 • 85 citations

Evidence for domain organization within the 61-kDa calmodulin-dependent cyclic nucleotide phosphodiesterase from bovine brain

1991 • 85 citations

Capacitative Ca2+ entry regulates Ca2+-sensitive adenylyl cyclases

1994 • 82 citations

Presence of Cyclic Nucleotide Phosphodiesterases PDE1A, Existing as a Stable Complex with Calmodulin, and PDE3A in Human Spermatozoa1

2002 • 73 citations

Molecular cloning of cDNA encoding a “63”-kDa calmodulin-stimulated phosphodiesterase from bovine brain.

1992 • 72 citations

A highly active 120-kDa truncated mutant of the plasma membrane Ca2+ pump

1993 • 72 citations

Purification and properties of calmodulin-stimulated phosphodiesterase from mammalian brain.

1984 • 71 citations

Mechanics of membrane fusion

1998 • 70 citations

The effect of Met–>Leu mutations on calmodulin's ability to activate cyclic nucleotide phosphodiesterase.

1994 • 68 citations

Differential recognition of calmodulin-enzyme complexes by a conformation-specific anti-calmodulin monoclonal antibody.

1986 • 67 citations

Identification and Characterisation of a Human Calmodulin-Stimulated Phosphodiesterase PDE1B1

1997 • 67 citations

Calcium-Dependent and -Independent Interactions of the Calmodulin-Binding Domain of Cyclic Nucleotide Phosphodiesterase with Calmodulin

1999 • 66 citations

A molecular mechanism for autoinhibition of myosin light chain kinases.

1993 • 65 citations

A polymerase chain reaction strategy to identify and clone cyclic nucleotide phosphodiesterase cDNAs. Molecular cloning of the cDNA encoding the 63-kDa calmodulin-dependent phosphodiesterase.

1992 • 65 citations

Phosphorylation and characterization of bovine heart calmodulin-dependent phosphodiesterase

1991 • 64 citations

Solution structure of calmodulin and its complex with a myosin light chain kinase fragment

1992 • 64 citations

Ins(1,4,5)P3 activates Drosophila cation channel Trpl in recombinant baculovirus-infected Sf9 insect cells

1995 • 63 citations

Purification and characterization of bovine lung calmodulin-dependent cyclic nucleotide phosphodiesterase. An enzyme containing calmodulin as a subunit.

1986 • 63 citations

Amino acid sequence of the cyclic GMP stimulated cyclic nucleotide phosphodiesterase from bovine heart

1990 • 60 citations

Phosphorylation of the 61-kDa Calmodulin-Stimulated Cyclic Nucleotide Phosphodiesterase at Serine 120 Reduces Its Affinity for Calmodulin

1994 • 58 citations

Regulatory region of plasma membrane Ca2+ pump. 28 residues suffice to bind calmodulin but more are needed for full auto-inhibition of the activity.

1994 • 56 citations

Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei

2002 • 55 citations

Identification of the major 68,000-dalton protein of microtubule preparations as a 10-nm filament protein and its effects on microtubule assembly in vitro

1979 • 53 citations

Regulation of T-Cell Activation by Phosphodiesterase 4B2 Requires Its Dynamic Redistribution during Immunological Synapse Formation

2003 • 52 citations

Definition of the inhibitory domain of smooth muscle myosin light chain kinase by site-directed mutagenesis

1991 • 50 citations

Human Ca2+/calmodulin-dependent phosphodiesterase PDE1A: novel splice variants, their specific expression, genomic organization, and chromosomal localization

2001 • 49 citations

Regulatory Mechanism of Ca2+/Calmodulin-dependent Protein Kinase Kinase

2000 • 49 citations

Identification of the phosphodiesterase regulated by muscarinic cholinergic receptors of 1321N1 human astrocytoma cells.

1986 • 48 citations

The Type 8 Adenylyl Cyclase Is Critical for Ca2+Stimulation of cAMP Accumulation in Mouse Parotid Acini

2000 • 47 citations

Inhibition of cAMP accumulation by intracellular calcium mobilization in C6-2B cells stably transfected with substance K receptor cDNA.

1991 • 47 citations

Sequence comparison of the 63-, 61-, and 59-kDa calmodulin-dependent cyclic nucleotide phosphodiesterases

1991 • 45 citations

Characterization of calmodulin-dependent cyclic nucleotide phosphodiesterase isoenzymes

1994 • 44 citations

Tryptophan fluorescence of calmodulin binding domain peptides interacting with calmodulin containing unnatural methionine analogues

2000 • 43 citations

19 Recent advances in the study of Ca2+/CaM-activated phosphodiesterases

1997 • 43 citations

Identification of detergent-resistant plasma membrane microdomains in dictyostelium: enrichment of signal transduction proteins.

1997 • 42 citations

Adenovirus-mediated Expression of an Olfactory Cyclic Nucleotide-gated Channel Regulates the Endogenous Ca2+-inhibitable Adenylyl Cyclase in C6-2B Glioma Cells

1999 • 40 citations

Capacitative Ca²⁺ entry is involved in cAMP synthesis in mouse parotid acini

1998 • 39 citations

Regulation of adenosine 3',5'-monophosphate content in human astrocytoma cells by isoproterenol and carbachol.

1977 • 38 citations

Regulation of cAMP concentration by calmodulin-dependent cyclic nucleotide phosphodiesterase

1986 • 38 citations

Adenylyl cyclase isoforms and signal integration in models of vascular smooth muscle cells

2001 • 37 citations

Adenovirus encoded cyclic nucleotide‐gated channels: a new methodology for monitoring cAMP in living cells

2001 • 36 citations

Muscarinic cholinergic receptor-mediated control of cyclic AMP metabolism. Agonist-induced changes in nucleotide synthesis and degradation.

1983 • 36 citations

Characterization of TbPDE2A, a Novel Cyclic Nucleotide-specific Phosphodiesterase from the Protozoan Parasite Trypanosoma brucei

2001 • 35 citations

The involvement of a calmodulin‐dependent phosphodiesterase in the negative control of carbamylcholine on cyclic AMP levels in dog thyroid slices

1983 • 34 citations

Isolation, Expression and Analysis of Splice Variants of a Human Ca2+/Calmodulin-Stimulated Phosphodiesterase (PDE1A)

1999 • 34 citations

Isolation and differential tissue distribution of two human cDNAs encoding PDE1 splice variants

2002 • 33 citations

Reciprocal regulation of calcium dependent and calcium independent cyclic AMP hydrolysis by protein phosphorylation

2002 • 31 citations

Sustained Entry of Ca2+ Is Required to Activate Ca2+-Calmodulin-dependent Phosphodiesterase 1A

2004 • 31 citations

Identification and characterization of DdPDE3, a cGMP-selective phosphodiesterase from Dictyostelium

2001 • 30 citations

Calmodulin-stimulated cyclic nucleotide phosphodiesterases in plasma membranes of bovine epididymal spermatozoa

1988 • 28 citations

Localization of cyclic nucleotide phosphodiesterase 2 in the brain-derived Triton-insoluble low-density fraction (raft)

2003 • 26 citations

Regulation of Adenylyl Cyclase Type V/VI in Smooth Muscle: Interplay of Inhibitory G Protein and Ca²⁺Influx

1998 • 24 citations

Purification and characterization of bovine brain calmodulin-dependent protein kinase II. The significance of autophosphorylation in the regulation of 63 kDa calmodulin-dependent cyclic nucleotide phosphodiesterase isozyme

1993 • 22 citations

Calmodulin-dependent high-affinity cyclic AMP phosphodiesterase in liver membranes

1981 • 19 citations

Active transducin α subunit carries PDE6 to detergent-resistant membranes in rod photoreceptor outer segments

2003 • 17 citations

Calmodulin-Dependent Cyclic AMP Phosphodiesterase in Liver Plasma Membranes: Stimulated by Insulin

1995 • 15 citations

Identification and characterization of DdPDE3, a cGMP-selective phosphodiesterase from Dictyostelium

2001 • 14 citations

Cloning of dog heart PDE1A – a first detailed characterization at the molecular level in this species

2001 • 13 citations

Differential expression and localization of calmodulin‐dependent phosphodiesterase genes during ontogenesis of chick dorsal root ganglion

2002 • 12 citations

Dynamics of calmodulin and cyclic AMP phosphodiesterase in plasma membranes of rat livers and ascites hepatomas

1981 • 11 citations

Calmodulin Kinase II Chimeras Used To Investigate the Structural Requirements for Smooth Muscle Myosin Light Chain Kinase Autoinhibition and Calmodulin-Dependent Activation

1999 • 9 citations

The Analysis and Assay of Cyclic Nucleotide Phosphodiesterase Isoenzyme Activity

2003 • 7 citations