Fusion Cell Vaccination of Patients with Metastatic Breast and Renal Cancer Induces Immunological and Clinical Responses

Immunobiology of Dendritic Cells

2000 • 6,653 citations

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

Vaccination of melanoma patients with peptide- or tumorlysate-pulsed dendritic cells

1998 • 2,916 citations

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

1998 • 2,378 citations

Antigen-Specific Inhibition of Effector T Cell Function in Humans after Injection of Immature Dendritic Cells

2001 • 1,384 citations

Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity

1995 • 1,097 citations

Immune and clinical responses in patients with metastatic melanoma to CD34(+) progenitor-derived dendritic cell vaccine.

2001 • 828 citations

Induction of antitumor activity by immunization with fusions of dendritic and carcinoma cells

1997 • 596 citations

Effect of interleukin‐10 on dendritic cell maturation and function

1997 • 571 citations

Regulatory Activity of Autocrine IL-10 on Dendritic Cell Functions

2001 • 562 citations

Murine dendritic cells loaded in vitro with soluble protein prime cytotoxic T lymphocytes against tumor antigen in vivo.

1996 • 561 citations

Idiotype-pulsed dendritic cell vaccination for B-cell lymphoma: clinical and immune responses in 35 patients

2002 • 553 citations

Rapid Induction of Tumor-specific Type 1 T Helper Cells in Metastatic Melanoma Patients by Vaccination with Mature, Cryopreserved, Peptide-loaded Monocyte-derived Dendritic Cells

2002 • 484 citations

Murine dendritic cells pulsed with whole tumor lysates mediate potent antitumor immune responsesin vitroandin vivo

1998 • 457 citations

CD4+ and CD8+ anergic T cells induced by interleukin-10–treated human dendritic cells display antigen-specific suppressor activity

2002 • 455 citations

Bone Marrow–generated Dendritic Cells Pulsed with Tumor Extracts or Tumor RNA Induce Antitumor Immunity against Central Nervous System Tumors

1997 • 443 citations

Induction of primary carcinoembryonic antigen (CEA)-specific cytotoxic T lymphocytes in vitro using human dendritic cells transfected with RNA

1998 • 403 citations

Dendritic Cells Genetically Modified with an Adenovirus Vector Encoding the cDNA for a Model Antigen Induce Protective and Therapeutic Antitumor Immunity

1997 • 390 citations

Dendritic cells from patients with myeloma are numerically normal but functionally defective as they fail to up-regulate CD80 (B7-1) expression after huCD40LT stimulation because of inhibition by transforming growth factor-β1 and interleukin-10

2001 • 346 citations

Vaccination of pediatric solid tumor patients with tumor lysate-pulsed dendritic cells can expand specific T cells and mediate tumor regression.

2001 • 321 citations

The B7/BB1 antigen provides one of several costimulatory signals for the activation of CD4+ T lymphocytes by human blood dendritic cells in vitro.

1992 • 273 citations

Tumors Promote Altered Maturation and Early Apoptosis of Monocyte-Derived Dendritic Cells

2000 • 245 citations

Reversal of tolerance to human MUC1 antigen in MUC1 transgenic mice immunized with fusions of dendritic and carcinoma cells

1998 • 239 citations

IL-12: a key cytokine in immune regulation

1996 • 236 citations

Induction of Tumor-Specific Cytotoxic T Lymphocytes in Cancer Patients by Autologous Tumor RNA-Transfected Dendritic Cells

2002 • 206 citations

Activation of antitumor cytotoxic T lymphocytes by fusions of human dendritic cells and breast carcinoma cells

2000 • 199 citations

Physical interaction between dendritic cells and tumor cells results in an immunogen that induces protective and therapeutic tumor rejection.

1998 • 179 citations

Induction of Antitumor Immunity by Vaccination of Dendritic Cells Transfected with MUC1 RNA

2000 • 174 citations

Tumor-induced interleukin 10 suppresses the ability of splenic dendritic cells to stimulate CD4 and CD8 T-cell responses.

2003 • 168 citations

Production of IL-12 by Human Monocyte-Derived Dendritic Cells Is Optimal When the Stimulus Is Given at the Onset of Maturation, and Is Further Enhanced by IL-4

2001 • 154 citations

Mature dendritic cells pulsed with freeze–thaw cell lysates define an effective in vitro vaccine designed to elicit EBV-specific CD4+ and CD8+ T lymphocyte responses

2000 • 152 citations

In vitro generation of human cytolytic T-cells specific for peptides derived from the HER-2/neu protooncogene protein.

1994 • 150 citations

Cutting Edge: Physical Interaction Between Dendritic Cells and Tumor Cells Results in an Immunogen That Induces Protective and Therapeutic Tumor Rejection

1998 • 141 citations

A tumor-associated and self antigen peptide presented by dendritic cells may induce T cell anergy in vivo, but IL-12 can prevent or revert the anergic state.

1997 • 127 citations

Immunization against murine multiple myeloma with fusions of dendritic and plasmacytoma cells is potentiated by interleukin 12

2002 • 123 citations

Antitumor Effect of Immunizations With Fusions of Dendritic and Glioma Cells in a Mouse Brain Tumor Model

2001 • 107 citations

Dendritic cells: development, function and potential use for cancer immunotherapy

1999 • 105 citations

Activation of natural killer cells with interleukin 2 (IL‐2) and IL‐12 increases perforin binding and subsequent lysis of tumour cells

2001 • 101 citations

The Hematopoietic Development of Dendritic Cells: A Distinct Pathway for Myeloid Differentiation

1996 • 89 citations

Immunogenicity and Therapeutic Efficacy of Dendritic–Tumor Hybrid Cells Generated by Electrofusion

2002 • 83 citations

Therapy of established tumour with a hybrid cellular vaccine generated by using granulocyte–macrophage colony‐stimulating factor genetically modified dendritic cells

1999 • 74 citations

Bone Marrow and Peripheral Blood Dendritic Cells From Patients With Multiple Myeloma Are Phenotypically and Functionally Normal Despite the Detection of Kaposi’s Sarcoma Herpesvirus Gene Sequences

1999 • 66 citations

Tumour cell–dendritic cell fusion for cancer immunotherapy: comparison of therapeutic efficiency of polyethylen‐glycol versus electro‐fusion protocols

2002 • 55 citations

Selective loss of human leukocyte antigen class I allele expression in advanced renal cell carcinoma.

1996 • 45 citations

Modulation of MUC1 mucin as an escape mechanism of breast cancer cells from autologous cytotoxic T-lymphocytes

2001 • 42 citations

IL-12 and Mutant P53 Peptide-Pulsed Dendritic Cells for the Specific Immunotherapy of Cancer

1996 • 39 citations

Mature dendritic cells pulsed with freeze–thaw cell lysates define an effective in vitro vaccine designed to elicit EBV-specific CD4+ and CD8+ T lymphocyte responses

2000 • 37 citations

Immune reconstitution following high-dose chemotherapy with stem cell rescue in patients with advanced breast cancer

2000 • 33 citations