Interactions between HIV rev and nuclear import and export factors: the rev nuclear localisation signal mediates specific binding to human importin-β

The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA

1989 • 1,280 citations

Identification of a signal for rapid export of proteins from the nucleus

1995 • 1,186 citations

The HIV-1 Rev Activation Domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs

1995 • 1,127 citations

Nucleocytoplasmic Transport

1996 • 1,071 citations

Nucleocytoplasmic transport: signals, mechanisms and regulation

1997 • 987 citations

Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins

1995 • 767 citations

Functional dissection of the HIV-1 Rev trans-activator—Derivation of a trans-dominant repressor of Rev function

1989 • 742 citations

HTLV-III expression and production involve complex regulation at the levels of splicing and translation of viral RNA

1986 • 673 citations

A Novel Receptor-Mediated Nuclear Protein Import Pathway

1996 • 669 citations

Identification of different roles for RanGDP and RanGTP in nuclear protein import.

1996 • 644 citations

A second post-transcriptional trans-activator gene required for HTLV-III replication

1986 • 639 citations

rev protein of human immunodeficiency virus type 1 affects the stability and transport of the viral mRNA.

1989 • 634 citations

Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope

1995 • 511 citations

HIV-1 structural gene expression requires the binding of multiple Rev monomers to the viral RRE: Implications for HIV-1 latency

1991 • 422 citations

A 41 amino acid motif in importin-alpha confers binding to importin-beta and hence transit into the nucleus.

1996 • 419 citations

Sequence-specific RNA binding by the HIV-1 Rev protein

1989 • 384 citations

Specific binding of HIV-1 recombinant Rev protein to the Rev-responsive element in vitro

1989 • 377 citations

Dominant-negative mutants of importin-beta block multiple pathways of import and export through the nuclear pore complex

1997 • 365 citations

Intragenic cis-acting art gene-responsive sequences of the human immunodeficiency virus.

1988 • 355 citations

HIV-1 regulator of virion expression (Rev) protein binds to an RNA stem-loop structure located within the Rev response element region

1990 • 354 citations

Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences

1995 • 337 citations

A Distinct Nuclear Import Pathway Used by Ribosomal Proteins

1997 • 335 citations

Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteins

1995 • 308 citations

Kap104p: A Karyopherin Involved in the Nuclear Transport of Messenger RNA Binding Proteins

1996 • 306 citations

The HIV-1 Rev trans-activator shuttles between the nucleus and the cytoplasm.

1994 • 305 citations

Nuclear protein import

1997 • 296 citations

Eukaryotic initiation factor 5A is a cellular target of the human immunodeficiency virus type 1 Rev activation domain mediating trans-activation.

1993 • 290 citations

Mutational definition of the human immunodeficiency virus type 1 Rev activation domain

1991 • 276 citations

A human nucleoporin-like protein that specifically interacts with HIV Rev

1995 • 268 citations

Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins.

1995 • 264 citations

Identification of sequences important in the nucleolar localization of human immunodeficiency virus Rev: relevance of nucleolar localization to function

1990 • 257 citations

Oligomerization and RNA binding domains of the type 1 human immunodeficiency virus Rev protein: a dual function for an arginine-rich binding motif.

1991 • 253 citations

The conserved amino-terminal domain of hSRP1 alpha is essential for nuclear protein import.

1996 • 252 citations

Mechanisms of nuclear protein import

1995 • 241 citations

Identification of a novel nuclear pore-associated protein as a functional target of the HIV-1 Rev protein in yeast

1995 • 223 citations

Inhibition of HIV-1 Replication in Lymphocytes by Mutants of the Rev Cofactor eIF-5A

1996 • 218 citations

A GTPase Controlling Nuclear Trafficking: Running the Right Way or Walking RANdomly?

1996 • 211 citations

Human immunodeficiency virus type 1 regulator of virion expression, rev, forms nucleoprotein filaments after binding to a purine-rich "bubble" located within the rev-responsive region of viral mRNAs.

1991 • 200 citations

Importin Provides a Link between Nuclear Protein Import and U snRNA Export

1996 • 189 citations

Secondary Structure is the Major Determinant for Interaction of HIV rev Protein with RNA

1990 • 188 citations

A Molecular Rheostat

1994 • 184 citations

RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1.

1994 • 176 citations

Rch1, a protein that specifically interacts with the RAG-1 recombination-activating protein.

1994 • 169 citations

Differential Expression and Sequence-specific Interaction of Karyopherin α with Nuclear Localization Sequences

1997 • 168 citations

A nuclear export signal is essential for the cytosolic localization of the Ran binding protein, RanBP1.

1996 • 155 citations

Characterization of the nuclear protein import mechanism using Ran mutants with altered nucleotide binding specificities.

1996 • 137 citations

The human immunodeficiency virus type 1 Rev protein shuttles between the cytoplasm and nuclear compartments.

1994 • 136 citations

Functional similarity of HIV-I rev and HTLV-I rex proteins: Identification of a new nucleolar-targeting signal in rev protein

1989 • 131 citations

Nuclear transport of human immunodeficiency virus type 1, visna virus, and equine infectious anemia virus Rev proteins: identification of a family of transferable nuclear export signals

1996 • 119 citations

Analysis of Trafficking of Rev and Transdominant Rev Proteins in Living Cells Using Green Fluorescent Protein Fusions: Transdominant Rev Blocks the Export of Rev from the Nucleus to the Cytoplasm1

1995 • 114 citations

Amphibian transcription factor IIIA proteins contain a sequence element functionally equivalent to the nuclear export signal of human immunodeficiency virus type 1 Rev.

1996 • 110 citations

HIV Rev uses a conserved cellular protein export pathway for the nucleocytoplasmic transport of viral RNAs

1996 • 106 citations

Nuclear protein import: Ran-GTP dissociates the karyopherin alphabeta heterodimer by displacing alpha from an overlapping binding site on beta.

1996 • 105 citations

Nucleolar Protein B23 Stimulates Nuclear Import of the HIV-1 Rev Protein and NLS-Conjugated Albumin

1997 • 101 citations

Sequence Determination and cDNA Cloning of Eukaryotic Initiation Factor 4D, the Hypusine-containing Protein

1989 • 98 citations

The Nuclear Localization Signal of Lymphoid Enhancer Factor-1 Is Recognized by Two Differentially Expressed Srp1-Nuclear Localization Sequence Receptor Proteins

1996 • 97 citations

A Role for Nucleoporin FG Repeat Domains in Export of Human Immunodeficiency Virus Type 1 Rev Protein and RNA from the Nucleus

1996 • 90 citations

Different Binding Domains for Ran-GTP and Ran-GDP/RanBP1 on Nuclear Import Factor p97

1997 • 86 citations

HIV-1 Rev expressed in recombinant Escherichia coli: purification, polymerization, and conformational properties

1991 • 86 citations

HIV-1 Rev Is Capable of Shuttling between the Nucleus and Cytoplasm

1994 • 84 citations

Functional mapping of the human immunodeficiency virus type 1 Rev RNA binding domain: new insights into the domain structure of Rev and Rex

1991 • 79 citations

Posttranscriptional regulation by the human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex proteins through a heterologous RNA binding site

1992 • 79 citations

Molecular interactions between the importin α/β heterodimer and proteins involved in vertebrate nuclear protein import

1997 • 70 citations

The Human Immunodeficiency Virus Long Terminal Repeat Includes a Specialised Initiator Element which is Required for Tat-responsive Transcription

1995 • 65 citations

Nucleocytoplasmic Transport of the Rev Protein of Human Immunodeficiency Virus Type 1 Is Dependent on the Activation Domain of the Protein

1995 • 63 citations

Flexible Regions of RNA Structure Facilitate Co-operative Rev Assembly on the Rev-response Element

1996 • 59 citations

Functional domains of the HIV-1 rev gene required for trans-regulation and subcellular localization

1990 • 53 citations

The Subcellular Distribution of Eukaryotic Translation Initiation Factor, eIF-5A, in Cultured Cells

1996 • 49 citations

Scanning mutagenesis of the arginine-rich region of the human immunodeficiency virus type 1 Rev trans activator

1994 • 44 citations

Nuclear preservation and cytoplasmic degradation of human immunodeficiency virus type 1 Rev protein

1996 • 37 citations